(Q34152191)

31 July 2017

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title

LY404187: a novel positive allosteric modulator of AMPA receptors (English)

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31 July 2017

Jennifer C Quirk

1

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PubMed ID

12353058

31 July 2017

Eric S Nisenbaum

series ordinal

2

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31 July 2017

1 January 2002

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CNS Neuroscience & Therapeutics

31 July 2017

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31 July 2017

8

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31 July 2017

3

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31 July 2017

255-282

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The glutamate receptor ion channels

31 July 2017

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12 December 2020

Synergistic interactions between ampakines and antipsychotic drugs

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12 December 2020

Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain.

1 reference

12 December 2020

Glutamatergic and dopaminergic afferents to the prefrontal cortex regulate spatial working memory in rats.

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12 December 2020

Expression mechanisms underlying NMDA receptor-dependent long-term potentiation

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12 December 2020

Interactive effects of subanesthetic ketamine and haloperidol in healthy humans.

1 reference

12 December 2020

NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders

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12 December 2020

Glutamate receptor expression in schizophrenic brain

1 reference

12 December 2020

Therapeutic potential of positive AMPA receptor modulators in the treatment of neurological disease

1 reference

12 December 2020

1 reference

12 December 2020

Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

1 reference

12 December 2020

Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic acid (AMPA) receptors

1 reference

12 December 2020

On the role of cortical glutamate in obsessive-compulsive disorder and attention-deficit hyperactivity disorder, two phenomenologically antithetical conditions

1 reference

12 December 2020

Physical activity-antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model

1 reference

12 December 2020

Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence

1 reference

12 December 2020

Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro

1 reference

12 December 2020

Pharmacological effects of AMPA receptor potentiators LY392098 and LY404187 on rat neuronal AMPA receptors in vitro

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12 December 2020

Potentiation of responses to AMPA on central neurones by LY392098 and LY404187 in vivo

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12 December 2020

Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors

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12 December 2020

Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator.

1 reference

12 December 2020

Antidepressant-like actions of an AMPA receptor potentiator (LY392098).

1 reference

12 December 2020

Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors in prefrontal cortical pyramidal neurons by a novel allosteric potentiator.

1 reference

12 December 2020

Absolute quantification of AMPA receptor subunit mRNAs in single hippocampal neurons

1 reference

12 December 2020

[3H]N-2-(4-(N-benzamido)phenyl)propyl-2-propanesulfonamide: a novel AMPA receptor potentiator and radioligand

1 reference

12 December 2020

Biological contributions to the presentation and understanding of attention-deficit/hyperactivity disorder: a review

1 reference

12 December 2020

AMPA receptors: potential implications in development and disease

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12 December 2020

Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter

1 reference

12 December 2020

A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia

1 reference

12 December 2020

Antidepressant-like effects of aniracetam in aged rats and its mode of action

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12 December 2020

Depresssion--emerging insights from neurobiology

1 reference

12 December 2020

Excitatory Amino Acid Pathway from the Hippocampus to the Prefrontal Cortex. Contribution of AMPA Receptors in Hippocampo-prefrontal Cortex Transmission

1 reference

12 December 2020

Study of a new schizophrenomimetic drug; sernyl.

1 reference

12 December 2020

Syndromes of schizophrenia on factor analysis

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12 December 2020

Factors regulating the magnitude of long-term potentiation induced by theta pattern stimulation

1 reference

12 December 2020

Frontal lobe functions in attention deficit disorder with and without hyperactivity: a review and research report

1 reference

12 December 2020

Identification of a site in glutamate receptor subunits that controls calcium permeability

1 reference

12 December 2020

Recent advances in the phencyclidine model of schizophrenia

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12 December 2020

Glutamate-operated channels: developmentally early and mature forms arise by alternative splicing.

1 reference

12 December 2020

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

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12 December 2020

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12 December 2020

Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport ofPhaseolus vulgaris-leucoagglutinin

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12 December 2020

Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam

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12 December 2020

The role of frontal dysfunction in attention deficit hyperactivity disorder

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12 December 2020

A family of AMPA-selective glutamate receptors

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12 December 2020

Cerebral glucose metabolism in adults with hyperactivity of childhood onset

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12 December 2020

Concanavalin A selectively reduces desensitization of mammalian neuronal quisqualate receptors

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12 December 2020

Striatal dysfunction in attention deficit and hyperkinetic disorder

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12 December 2020

Long-term synaptic potentiation

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12 December 2020

Effects of nootropic drugs in a scopolamine-induced amnesia model in mice

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12 December 2020

Acquisition of attention skill in pervasively hyperactive children

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12 December 2020

Effects of aniracetam on delayed matching-to-sample performance of monkeys and pigeons.

1 reference

12 December 2020

Piracetam improves visuomotor and cognitive deficits in early Parkinsonism--a pilot study.

1 reference

12 December 2020

Piracetam impairs the overshadowing of background stimuli by an informative CS

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12 December 2020

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate

1 reference

12 December 2020

Magnesium gates glutamate-activated channels in mouse central neurones

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12 December 2020

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

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12 December 2020

Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments.

1 reference

12 December 2020

Interactions among GYKI-52466, cyclothiazide, and aniracetam at recombinant AMPA and kainate receptors.

1 reference

12 December 2020

Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia

1 reference

12 December 2020

Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS

1 reference

12 December 2020

The mechanism of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor desensitization after removal of glutamate

1 reference

12 December 2020

Working memory dysfunction in schizophrenia

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12 December 2020

SPECT brain imaging abnormalities in attention deficit hyperactivity disorder.

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12 December 2020

Anxiolytic activity of piracetam, a nootropic agent, following subchronic administration in rodents.

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12 December 2020

Centrally active modulators of glutamate receptors facilitate the induction of long-term potentiation in vivo

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12 December 2020

A molecular determinant for submillisecond desensitization in glutamate receptors

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12 December 2020

Control of kinetic properties of AMPA receptor channels by nuclear RNA editing

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12 December 2020

Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants

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12 December 2020

Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents.

1 reference

12 December 2020

Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses

1 reference

12 December 2020

Aniracetam. An overview of its pharmacodynamic and pharmacokinetic properties, and a review of its therapeutic potential in senile cognitive disorders

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12 December 2020

AMPA-selective glutamate receptor subtype immunoreactivity in the entorhinal cortex of non-demented elderly and patients with Alzheimer's disease.

1 reference

12 December 2020

Cloned glutamate receptors

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12 December 2020

Facilitation of glutamate receptors enhances memory

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12 December 2020

AMPA glutamate receptor subunits are differentially distributed in rat brain

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12 December 2020

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12 December 2020

Effect of chronic piracetam on age-related changes of cross-maze exploration in mice.

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12 December 2020

Correlation between kinetics and RNA splicing of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in neocortical neurons.

1 reference

12 December 2020

AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate.

1 reference

12 December 2020

Facilitation of glutamate receptors reverses an age-associated memory impairment in rats

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12 December 2020

Prefrontal function in schizophrenia: confounds and controversies

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12 December 2020

Antidepressant-like effect of brain-derived neurotrophic factor (BDNF).

1 reference

12 December 2020

GluR2 glutamate receptor subunit flip and flop isoforms are decreased in the hippocampal formation in schizophrenia: a reverse transcriptase-polymerase chain reaction (RT-PCR) study

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12 December 2020

The role of the prefrontal cortex in higher cognitive functions

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12 December 2020

Immunoautoradiographic evidence for a loss of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia.

1 reference

12 December 2020

Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans.

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12 December 2020

Synchronization processes in the mechanisms of short-term memory in monkeys: the involvement of cholinergic and glutaminergic cortical structures.

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12 December 2020

AMPA receptor facilitation accelerates fear learning without altering the level of conditioned fear acquired.

1 reference

12 December 2020

High-resolution brain SPECT imaging in ADHD.

1 reference

12 December 2020

Enhancement by an ampakine of memory encoding in humans.

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12 December 2020

The loss of GluR2(3) immunoreactivity precedes neurofibrillary tangle formation in the entorhinal cortex and hippocampus of Alzheimer brains.

1 reference

12 December 2020

The glutamatergic dysfunction hypothesis for schizophrenia

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12 December 2020

Differential dependence on GluR2 expression of three characteristic features of AMPA receptors.

1 reference

12 December 2020

Schizophrenia and glutamatergic transmission

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12 December 2020

Facilitative effects of the ampakine CX516 on short-term memory in rats: enhancement of delayed-nonmatch-to-sample performance.

1 reference

12 December 2020

Glutamate receptors in the mammalian central nervous system

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12 December 2020

Physiological and molecular properties of AMPA/Kainate receptors expressed by striatal medium spiny neurons.

1 reference

12 December 2020

Rett syndrome, EEG and the motor cortex as a model for better understanding of attention deficit hyperactivity disorder (ADHD).

1 reference

12 December 2020

Modulating excitatory synaptic neurotransmission: potential treatment for neurological disease?

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12 December 2020

Structure of a glutamate-receptor ligand-binding core in complex with kainate

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12 December 2020

Expression of NMDAR1, GluR1, GluR7, and KA1 glutamate receptor mRNAs is decreased in frontal cortex of "neuroleptic-free" schizophrenics: evidence on reversible up-regulation by typical neuroleptics.

1 reference

12 December 2020

Functional brain electrical activity mapping in boys with attention-deficit/hyperactivity disorder.

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12 December 2020

The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn

1 reference

12 December 2020

Identifiers

PubMed ID

12353058

1 reference

PubMed ID

12353058