(Q34166520)

English

Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis.

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scholarly article

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Europe PubMed Central

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16 February 2020

Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis (English)

1 reference

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16 February 2020

schistosomiasis

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Lee A Borthwick

3

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16 February 2020

author name string

Kevin M Vannella

1

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16 February 2020

Luke Barron

2

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16 February 2020

Kristen N Kindrachuk

4

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16 February 2020

Prakash Babu Narasimhan

5

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16 February 2020

Kevin M Hart

6

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16 February 2020

Robert W Thompson

7

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16 February 2020

Sandra White

8

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16 February 2020

Allen W Cheever

9

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16 February 2020

Thirumalai R Ramalingam

10

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16 February 2020

Thomas A Wynn

11

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16 February 2020

publication date

11 September 2014

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16 February 2020

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16 February 2020

10

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16 February 2020

9

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16 February 2020

e1004372

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16 February 2020

copyright license

Creative Commons CC0 License

11 September 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

Macrophage activation and polarization: nomenclature and experimental guidelines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Macrophage biology in development, homeostasis and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Host responses in tissue repair and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Macrophage activation governs schistosomiasis-induced inflammation and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13Rα2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Quantitative assessment of macrophage functions in repair and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Macrophages: master regulators of inflammation and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Alternative activation of macrophages: an immunologic functional perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Exploring the full spectrum of macrophage activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Immunopathogenesis of schistosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Fibrotic disease and the T(H)1/T(H)2 paradigm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Enhancer-mediated control of macrophage-specific arginase I expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Alternative activation of macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

5 July 2018

Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004372

21 January 2018

Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004372

21 January 2018

Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004372

21 January 2018

Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004372

21 January 2018

Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004372

21 January 2018

Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004372

21 January 2018

Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

28 October 2018

Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

28 October 2018

IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161449

28 October 2018

An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004372

21 January 2018

Allergic airway disease is unaffected by the absence of IL-4Rα-dependent alternatively activated macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/25211233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25211233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25211233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/25211233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PPAT.1004372

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25211233%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25211233%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

Europe PubMed Central

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16 February 2020

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