(Q34167954)

31 July 2017

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title

Transcription factor regulation of B lineage commitment (English)

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31 July 2017

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B L Kee

1

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31 July 2017

C Murre

series ordinal

2

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31 July 2017

publication date

1 April 2001

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Current Opinion in Immunology

31 July 2017

published in

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31 July 2017

volume

13

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31 July 2017

issue

2

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31 July 2017

page(s)

180-185

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Transcriptional regulation of early B-lymphocyte differentiation

31 July 2017

cites work

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B-cell-specific DNA binding by an E47 homodimer

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7 January 2021

E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins

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E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

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B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.

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Both E12 and E47 allow commitment to the B cell lineage

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E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells

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Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line

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EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes

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The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development

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7 January 2021

Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression

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7 January 2021

Failure of B-cell differentiation in mice lacking the transcription factor EBF.

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Purification of early-B-cell factor and characterization of its DNA-binding specificity

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EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains

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7 January 2021

The B29 (immunoglobulin beta-chain) gene is a genetic target for early B-cell factor

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7 January 2021

A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation

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Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

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Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

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7 January 2021

Early function of Pax5 (BSAP) before the pre-B cell receptor stage of B lymphopoiesis

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7 January 2021

Dependence of BSAP repressor and activator functions on BSAP concentration

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7 January 2021

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

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7 January 2021

Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

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7 January 2021

Independent regulation of the two Pax5 alleles during B-cell development.

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7 January 2021

Hypothesis: genes which function in a stochastic lineage commitment process are subject to monoallelic expression.

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7 January 2021

LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]

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7 January 2021

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions

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7 January 2021

Functional interaction of beta-catenin with the transcription factor LEF-1

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7 January 2021

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

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7 January 2021

LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic.

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7 January 2021

Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia

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7 January 2021

Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism

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7 January 2021

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

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7 January 2021

Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates

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7 January 2021

10.1016/S0952-7915(00)00202-8

Identifiers

DOI

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31 July 2017

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