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Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension.
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129977
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14 December 2019
title
Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension
(English)
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129977
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14 December 2019
author
Katie B. Shannon
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1
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129977
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14 December 2019
author name string
Julie C Canman
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2
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129977
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14 December 2019
E D Salmon
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3
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129977
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14 December 2019
publication date
1 October 2002
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14 December 2019
published in
Molecular Biology of the Cell
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Europe PubMed Central
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129977
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14 December 2019
volume
13
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Europe PubMed Central
PMCID
129977
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12388768%20AND%20SRC:MED&resulttype=core&format=json
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14 December 2019
page(s)
3706-3719
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129977
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14 December 2019
issue
10
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14 December 2019
cites work
Inducing precocious anaphase in cultured mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Spindle checkpoint requires Mad1-bound and Mad1-free Mad2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Dynein is a transient kinetochore component whose binding is regulated by microtubule attachment, not tension
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Kinetochore "memory" of spindle checkpoint signaling in lysed mitotic cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
The role of pre- and post-anaphase microtubules in the cytokinesis phase of the cell cycle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
The polarity and dynamics of microtubule assembly in the budding yeast Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
The kinetochore of higher eucaryotes: a molecular view
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Whose end is destruction: cell division and the anaphase-promoting complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Localization of Mad2 to kinetochores depends on microtubule attachment, not tension
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Kinetochore fiber maturation in PtK1 cells and its implications for the mechanisms of chromosome congression and anaphase onset
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
How proteolysis drives the cell cycle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Identification of a human mitotic checkpoint gene: hsMAD2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
The force for poleward chromosome motion in Haemanthus cells acts along the length of the chromosome during metaphase but only at the kinetochore during anaphase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Mitotic forces control a cell-cycle checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
High resolution multimode digital imaging system for mitosis studies in vivo and in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Differential expression of a phosphoepitope at the kinetochores of moving chromosomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
The attachment of kinetochores to the pro-metaphase spindle in PtK1 cells. Recovery from low temperature treatment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Newt lung epithelial cells: cultivation, use, and advantages for biomedical research.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Chromosome fiber dynamics and congression oscillations in metaphase PtK2 cells at 23 degrees C.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Feedback control of mitosis in budding yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
5 July 2018
Minor alteration of microtubule dynamics causes loss of tension across kinetochore pairs and activates the spindle checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
28 October 2018
Checkpoint signals in grasshopper meiosis are sensitive to microtubule attachment, but tension is still essential.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129977
retrieved
28 October 2018
Lack of tension at kinetochores activates the spindle checkpoint in budding yeast
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12388768
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Effect of hypothermia (20-25 degrees C) on mitosis in PtK1 cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12388768
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Microtubule dynamics in the chromosomal spindle fiber: analysis by fluorescence and high-resolution polarization microscopy
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12388768
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Oscillating mitotic newt lung cell kinetochores are, on average, under tension and rarely push
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12388768
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The spindle checkpoint
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12388768
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1091/MBC.E02-03-0137
1 reference
stated in
Europe PubMed Central
PMCID
129977
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12388768%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
PMCID
129977
1 reference
stated in
Europe PubMed Central
PMCID
129977
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12388768%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
PubMed ID
12388768
1 reference
stated in
Europe PubMed Central
PMCID
129977
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12388768%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
ResearchGate publication ID
6138028
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