(Q34168892)

English

Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

molecular chaperones

0 references

1 reference

based on heuristic

inferred from title

Gaucher's disease

1 reference

based on heuristic

inferred from title

author name string

Ethan D Goddard-Borger

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Michael B Tropak

2

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Sayuri Yonekawa

3

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Christina Tysoe

4

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Don J Mahuran

5

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Stephen G Withers

6

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

language of work or name

0 references

publication date

6 March 2012

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

55

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

2737-2745

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Gastrointestinal disturbances and their management in miglustat-treated patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Identification and characterization of pharmacological chaperones to correct enzyme deficiencies in lysosomal storage disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Pharmacological chaperone therapy for Gaucher disease: a patent review.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Polyhydroxylated bicyclic isoureas and guanidines are potent glucocerebrosidase inhibitors and nanomolar enzyme activity enhancers in Gaucher cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

A Fluorescent sp2-iminosugar with pharmacological chaperone activity for gaucher disease: synthesis and intracellular distribution studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

X-ray and biochemical analysis of N370S mutant human acid β-glucosidase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Structural and thermodynamic analyses of α-L-fucosidase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Common and uncommon pathogenic cascades in lysosomal storage diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Improved management of lysosomal glucosylceramide levels in a mouse model of type 1 Gaucher disease using enzyme and substrate reduction therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Treating lysosomal storage diseases with pharmacological chaperones: from concept to clinics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Glycosphingolipids--nature, function, and pharmacological modulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

The pharmacological chaperone N-butyldeoxynojirimycin enhances enzyme replacement therapy in Pompe disease fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Phenotype, diagnosis, and treatment of Gaucher's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Isofagomine induced stabilization of glucocerebrosidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Mechanistic insights into glycosidase chemistry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Glycosidase inhibition: an assessment of the binding of 18 putative transition-state mimics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Direct multiplex assay of lysosomal enzymes in dried blood spots for newborn screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

The cell biology of lysosomal storage disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Genetic heterogeneity in Gaucher disease: physicokinetic and immunologic studies of the residual enzyme in cultured fibroblasts from non-neuronopathic and neuronopathic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

The Intrinsic PkA-Values of Functional Groups in Enzymes: Improper Deductions from the Ph-Dependence of Steady-State Parameter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

5 July 2018

Photoinduced thiol-ene coupling as a click ligation tool for thiodisaccharide synthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380069

28 October 2018

Hydrophilic iminosugar active-site-specific chaperones increase residual glucocerebrosidase activity in fibroblasts from Gaucher patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22360565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic vaccines of tumor-associated glycopeptide antigens by immune-compatible thioether linkage to bovine serum albumin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22360565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amphiphilic 1-Deoxynojirimycin Derivatives through Click Strategies for Chemical Chaperoning in N370S Gaucher Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22360565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ER retention and degradation as the molecular basis underlying Gaucher disease heterogeneity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22360565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The subunit and polypeptide structure of hexosaminidases from human placenta

1 reference

https://pubmed.ncbi.nlm.nih.gov/22360565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22360565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of glucocerebrosidase activity in dry blood spots using tandem mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/22360565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gaucher disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22360565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of highly potent and selective pharmacological chaperones for the treatment of Gaucher's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22360565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rational design and synthesis of highly potent beta-glucocerebrosidase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22360565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Second-generation iminoxylitol-based pharmacological chaperones for the treatment of Gaucher disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22360565

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based on heuristic

inferred from PubMed ID database lookup

Goal-oriented therapy with miglustat in Gaucher disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22360565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis, kinetic evaluation and cell-based analysis of C-alkylated isofagomines as chaperones of β-glucocerebrosidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22360565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM201633Y

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

ResearchGate publication ID

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