(Q34174861)

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Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides

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Europe PubMed Central

PubMed publication ID

31 July 2017

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides (English)

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31 July 2017

pharmacokinetics

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Stuart W McCombie

1

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31 July 2017

Jayaram R Tagat

2

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31 July 2017

Susan F Vice

3

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31 July 2017

Sue-Ing Lin

4

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31 July 2017

Ruo Steensma

5

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31 July 2017

Anandan Palani

6

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31 July 2017

Bernard R Neustadt

7

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31 July 2017

Bahige M Baroudy

8

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31 July 2017

Julie M Strizki

9

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31 July 2017

Michael Endres

10

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31 July 2017

Kathleen Cox

11

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31 July 2017

Niya Dan

12

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31 July 2017

Chuan-Chu Chou

13

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31 July 2017

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publication date

1 February 2003

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31 July 2017

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5

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Bioorganic & Medicinal Chemistry Letters

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31 July 2017

13

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31 July 2017

3

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31 July 2017

567-571

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31 July 2017

Discovery of novel, potent, and selective small-molecule CCR5 antagonists as anti-HIV-1 agents: synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety

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CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines

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Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5.

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Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailabl

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Axially chiral N-benzyl-N,7-dimethyl-5-phenyl-1, 7-naphthyridine-6-carboxamide derivatives as tachykinin NK1 receptor antagonists: determination of the absolute stereochemical requirements.

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Atropisomeric Amides as Chiral Ligands: Using (−)-Sparteine-Directed Enantioselective Silylation to Control the Conformation of a Stereogenic Axis

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Synthesis of enantioenriched axially chiral anilides from atropisomerically enriched tartarate ortho-anilides

1 reference

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Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element

1 reference

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Reaction of N-Aminopyridinium Derivatives. V. Syntheses of 1-(N-Methylacetamido) alkylpyridinium Salts and Their Reaction with Cyanide Ion

1 reference

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Benzo- and pyrido-1,4-oxazepin-5-ones and -thiones: synthesis and structure-activity relationships of a new series of H1 antihistamines

1 reference

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SCH 57790: a novel M2 receptor selective antagonist

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Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes

1 reference

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SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

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Novel procedure for rapid pharmacokinetic screening of discovery compounds in rats

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Formamid-Reaktionen, XI. Darstellung, Eigenschaften und Umsetzungen des Pyrimidins

1 reference

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Discovery of 4-[(Z)-(4-bromophenyl)- (ethoxyimino)methyl]-1'-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4'-methyl-1,4'- bipiperidine N-oxide (SCH 351125): an orally bioavailable human CCR5 antagonist for the treatment of HIV infection

1 reference

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7 January 2021

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Identifiers

10.1016/S0960-894X(02)00918-6

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Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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