(Q34180241)

31 July 2017

title

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. (English)

1 reference

31 July 2017

J Chen

1

1 reference

31 July 2017

J Xie

2

1 reference

31 July 2017

Z Jiang

3

1 reference

31 July 2017

B Wang

4

1 reference

31 July 2017

Y Wang

5

1 reference

31 July 2017

X Hu

6

1 reference

31 July 2017

language of work or name

English

0 references

publication date

25 April 2011

1 reference

31 July 2017

1 reference

31 July 2017

volume

30

1 reference

31 July 2017

issue

42

1 reference

31 July 2017

page(s)

4297-4306

1 reference

https://scigraph.springernature.com/pub.10.1038/onc.2011.137

31 July 2017

exact match

0 references

cites work

Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Topoisomerase I poisons and suppressors as anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Identification of RIP1 kinase as a specific cellular target of necrostatins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Why do cancers have high aerobic glycolysis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Cancer cell metabolism: Warburg and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Bypassing cancer drug resistance by activating multiple death pathways--a proposal from the study of circumventing cancer drug resistance by induction of necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Allosteric regulation of pyruvate kinase M2 isozyme involves a cysteine residue in the intersubunit contact

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Antitumor activities of a newly synthesized shikonin derivative, 2-hyim-DMNQ-S-33.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Honokiol induces a necrotic cell death through the mitochondrial permeability transition pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Design, synthesis, and biological evaluation of N-carboxyphenylpyrrole derivatives as potent HIV fusion inhibitors targeting gp41

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Beta-hydroxyisovalerylshikonin induces apoptosis in human leukemia cells by inhibiting the activity of a polo-like kinase 1 (PLK1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Pyruvate kinase type M2 and its role in tumor growth and spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

A shikonin derivative, ??-hydroxyisovalerylshikonin, is an ATP-non-competitive inhibitor of protein tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

The monomer of pyruvate kinase, subtype M1, is both a kinase and a cytosolic thyroid hormone binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Identification of small molecule inhibitors of pyruvate kinase M2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

On the Origin of Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Naturally-occurring shikonin analogues--a class of necroptotic inducers that circumvent cancer drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Acylshikonin analogues: synthesis and inhibition of DNA topoisomerase-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Shikonin circumvents cancer drug resistance by induction of a necroptotic death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

Studies on pyruvate kinase (PK) deficiency. II. Electrophoretic, kinetic and immunological studies on pyruvate kinase of erythrocytes and other tissues.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

The Chemistry and Biology of Alkannin, Shikonin, and Related Naphthazarin Natural Products

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.137

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.137

1 reference

Dimensions Publication ID

31 July 2017

1019174410

0 references

1 reference