(Q34180681)

31 July 2017

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title

The development of COX2 inhibitors (English)

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31 July 2017

Rod J Flower

1

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31 July 2017

1 March 2003

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Nature Reviews Drug Discovery

31 July 2017

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31 July 2017

2

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31 July 2017

3

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31 July 2017

179-191

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https://scigraph.springernature.com/pub.10.1038/nrd1034

31 July 2017

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cites work

Salicylate and enzymes

1 reference

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

21 January 2018

1 reference

Release of noradrenaline from sympathetic endings.

21 January 2018

1 reference

Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol)

21 January 2018

1 reference

Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition

21 January 2018

1 reference

Acetylation of prostaglandin synthase by aspirin

21 January 2018

1 reference

Exaggerated prostaglandin biosynthesis and its influence on renal resistance in the isolated hydronephrotic rabbit kidney

21 January 2018

1 reference

Evidence for two distinct forms of fatty acid cyclooxygenase in brain.

21 January 2018

1 reference

Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases

21 January 2018

1 reference

Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice

21 January 2018

1 reference

Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme

21 January 2018

1 reference

Rapid induction of prostaglandin endoperoxide synthase in rat preovulatory follicles by luteinizing hormone and cAMP is blocked by inhibitors of transcription and translation

21 January 2018

1 reference

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing

21 January 2018

1 reference

Regulation of Prostaglandin Endoperoxide Synthase Gene Expression in Cultured Rat Mesangial Cells: Induction by Serum via a Protein Kinase-C-Dependent Mechanism

21 January 2018

1 reference

A collection of mRNA species that are inducible in the RAW 264.7 mouse macrophage cell line by gamma interferon and other agents

21 January 2018

1 reference

Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression

21 January 2018

1 reference

Structural determination and promoter analysis of the chicken mitogen-inducible prostaglandin G/H synthase gene and genetic mapping of the murine homolog

21 January 2018

1 reference

Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2

21 January 2018

1 reference

Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues

21 January 2018

1 reference

Prostaglandin G/H synthase isoenzyme 2 expression in fibroblasts: regulation by dexamethasone, mitogens, and oncogenes

21 January 2018

1 reference

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase

21 January 2018

1 reference

PGH synthase isoenzyme selectivity: the potential for safer nonsteroidal antiinflammatory drugs

21 January 2018

1 reference

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

21 January 2018

1 reference

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II.

21 January 2018

1 reference

Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

21 January 2018

1 reference

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic

21 January 2018

1 reference

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain

21 January 2018

1 reference

Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis

21 January 2018

1 reference

Pharmacological analysis of cyclooxygenase-1 in inflammation

21 January 2018

1 reference

Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase

21 January 2018

1 reference

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

21 January 2018

1 reference

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

21 January 2018

1 reference

A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.

21 January 2018

1 reference

The dynamics of prostaglandin H synthases. Studies with prostaglandin h synthase 2 Y355F unmask mechanisms of time-dependent inhibition and allosteric activation

21 January 2018

1 reference

Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase

21 January 2018

1 reference

Kinetic basis for selective inhibition of cyclo-oxygenases

21 January 2018

1 reference

Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis

21 January 2018

1 reference

Characterization of inducible cyclooxygenase in rat brain

21 January 2018

1 reference

Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response

21 January 2018

1 reference

Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction

21 January 2018

1 reference

Effects of celecoxib and rofecoxib on blood pressure and edema in patients > or =65 years of age with systemic hypertension and osteoarthritis

21 January 2018

1 reference

Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats

21 January 2018

1 reference

Nonsteroidal anti-inflammatory drugs may delay the repair of gastric mucosa by suppressing prostaglandin-mediated increase of hepatocyte growth factor production

21 January 2018

1 reference

Distribution of cyclooxygenase isoforms in murine chronic granulomatous inflammation. Implications for future anti-inflammatory therapy

21 January 2018

1 reference

Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2

21 January 2018

1 reference

Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage

21 January 2018

1 reference

Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2.

21 January 2018

1 reference

A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes

21 January 2018

1 reference

Nomenclature for COX-2 inhibitors.

21 January 2018

1 reference

Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group

21 January 2018

1 reference

Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study

21 January 2018

1 reference

The coxibs, selective inhibitors of cyclooxygenase-2.

21 January 2018

1 reference

Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate

21 January 2018

1 reference

Modes of action of aspirin-like drugs: salicylates inhibit erk activation and integrin-dependent neutrophil adhesion.

21 January 2018

1 reference

Sites of action for future therapy: an adenosine-dependent mechanism by which aspirin retains its antiinflammatory activity in cyclooxygenase-2 and NFkappaB knockout mice

21 January 2018

1 reference

Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB.

21 January 2018

1 reference

Treatment of low back pain exacerbations with willow bark extract: a randomized double-blind study

21 January 2018

1 reference

Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs

21 January 2018

1 reference

Nonsteroidal anti-inflammatory drugs, acetaminophen, cyclooxygenase 2, and fever.

21 January 2018

1 reference

Mechanism of action of acetaminophen: is there a cyclooxygenase 3?

21 January 2018

1 reference

COX-1, COX-2, and COX-3 and the future treatment of chronic inflammatory disease

21 January 2018

1 reference

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression

21 January 2018

1 reference

Involvement of peripheral cyclooxygenase-1 and cyclooxygenase-2 in inflammatory pain

21 January 2018

1 reference

The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models

21 January 2018

1 reference

Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans.

21 January 2018

1 reference

The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2(-/-), but not in cyclooxygenase-1(-/-) mice

21 January 2018

1 reference

Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.

21 January 2018

1 reference

Mechanism of acetaminophen inhibition of cyclooxygenase isoforms

21 January 2018

1 reference

Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor

21 January 2018

1 reference

Aspirin-like molecules that covalently inactivate cyclooxygenase-2.

21 January 2018

1 reference

Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors

21 January 2018

1 reference

Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors

21 January 2018

1 reference

Nonsteroidal anti-inflammatory drugs, eicosanoids, and colorectal cancer prevention

21 January 2018

1 reference

The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis

21 January 2018

1 reference

Risk of Alzheimer's disease and duration of NSAID use.

21 January 2018

1 reference

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain.

21 January 2018

1 reference

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

21 January 2018

1 reference

Medicine: lipid signals in pain control

21 January 2018

1 reference

Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa

21 January 2018

1 reference

Indomethacin and aspirin abolish prostaglandin release from the spleen

21 January 2018

1 reference

Aspirin selectively inhibits prostaglandin production in human platelets

31 March 2020

1 reference

Effect of aspirin on human seminal prostaglandins

31 March 2020

1 reference

Relationship between inhibition of prostaglandin synthesis and drug efficacy: Support for the current theory on mode of action of aspirin-like drugs

31 March 2020

1 reference

Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts

31 March 2020

1 reference

Selective inhibition of cyclooxygenase 2

31 March 2020

1 reference

Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation

31 March 2020

1 reference

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

31 March 2020

1 reference

The interaction of arginine 106 of human prostaglandin G/H synthase-2 with inhibitors is not a universal component of inhibition mediated by nonsteroidal anti-inflammatory drugs

31 March 2020

1 reference

Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1

31 March 2020

1 reference

Mechanisms of mucosal injury and healing: the role of non-steroidal anti-inflammatory drugs

31 March 2020

1 reference

Selective inhibitors of cyclooxygenase-2: are they really effective, selective, and GI-safe?

31 March 2020

1 reference

NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2

31 March 2020

1 reference

Systematic pharmacological approach to the characterization of NSAIDs

31 March 2020

1 reference

Inhibition of prostaglandin synthesis in man

31 March 2020

1 reference

Salicylate metabolites inhibit cyclooxygenase-2-dependent prostaglandin E(2) synthesis in murine macrophages

31 March 2020

1 reference

Salicylate or aspirin inhibits the induction of the inducible nitric oxide synthase in rat cardiac fibroblasts

31 March 2020

1 reference

Cell-type-specific activation of c-Jun N-terminal kinase by salicylates

31 March 2020

1 reference

Non-steroidal anti-inflammatory drugs: back to the future

31 March 2020

1 reference

Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationships

31 March 2020

1 reference

Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents

31 March 2020

1 reference

Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators

31 March 2020

1 reference

Inhibition by corticosteroids of epidermal growth factor-induced recovery of cyclooxygenase after aspirin inactivation

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Induction of prostaglandin endoperoxide synthase-1 (COX-1) in a human promonocytic cell line by treatment with the differentiating agent TPA.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1034

1 reference

31 July 2017

1 reference

PubMed ID

12612644