(Q34192388)

31 July 2017

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title

Overview and perspective on the therapy of Alzheimer's disease from a preclinical viewpoint (English)

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31 July 2017

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Pepeu G

1

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31 July 2017

publication date

1 January 2001

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Progress in Neuro-Psychopharmacology & Biological Psychiatry

31 July 2017

published in

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31 July 2017

volume

25

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31 July 2017

issue

1

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31 July 2017

page(s)

193-209

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Administration of amyloid beta-peptides into the medial septum of rats decreases acetylcholine release from hippocampus in vivo.

31 July 2017

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Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's Disease

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7 January 2021

Paired helical filament-like phosphorylation of tau, deposition of beta/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A

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7 January 2021

The use of okadaic acid in vivo and the induction of molecular changes typical for Alzheimer's disease

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7 January 2021

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

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7 January 2021

Aniracetam restores object recognition impaired by age, scopolamine, and nucleus basalis lesions.

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7 January 2021

The cholinergic hypothesis of geriatric memory dysfunction

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7 January 2021

Cholinergic deafferentation of the rabbit cortex: a new animal model of Abeta deposition

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7 January 2021

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

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7 January 2021

Methodological variables in the assessment of beta amyloid neurotoxicity

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7 January 2021

Unilateral and bilateral nucleus basalis lesions: Differences in neurochemical and behavioural recovery

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7 January 2021

Selective loss of central cholinergic neurons in Alzheimer's disease

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7 January 2021

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7 January 2021

Memory and cognitive function in man: Does the cholinergic system have a specific role?

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7 January 2021

Alzheimer disease: mouse models pave the way for therapeutic opportunities

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7 January 2021

Central cholinergic systems and cognition

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7 January 2021

Aging, metabolism, and Alzheimer disease: review and hypotheses

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7 January 2021

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor.

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7 January 2021

Differential effects of amyloid peptides beta-(1-40) and beta-(25-35) injections into the rat nucleus basalis.

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7 January 2021

Long-term changes in the aggregation state and toxic effects of beta-amyloid injected into the rat brain

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7 January 2021

Phosphoprotein phosphatase activities in Alzheimer disease brain

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7 January 2021

Facilitation of glutamate receptors reverses an age-associated memory impairment in rats

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7 January 2021

Alzheimer's disease: the amyloid cascade hypothesis

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7 January 2021

Neuroprotective approaches in experimental models of beta-amyloid neurotoxicity: relevance to Alzheimer's disease

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7 January 2021

Propionyl-IIGL tetrapeptide antagonizes beta-amyloid excitotoxicity in rat nucleus basalis

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https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Peripheral administration of novel anti-inflammatories can attenuate the effects of chronic inflammation within the CNS.

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https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Behavioral and ultrastructural changes induced by chronic neuroinflammation in young rats.

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7 January 2021

Damaged neuronal energy metabolism and behavior are improved by Ginkgo biloba extract (EGb 761).

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7 January 2021

Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type?

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7 January 2021

Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: a cross-sectional comparison against advanced late-onset and incipient early-onset cases

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7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam

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https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

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https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Effects of Estradiol (-17beta) on learning, memory and cerebral energy metabolism in male rats after intracerebroventricular administration of streptozotocin.

1 reference

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7 January 2021

The nucleus basalis magnocellularis: The origin of a cholinergic projection to the neocortex of the rat

1 reference

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7 January 2021

Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation

1 reference

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7 January 2021

Lesions of cholinergic forebrain nuclei: changes in avoidance behavior and scopolamine actions.

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7 January 2021

Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging.

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7 January 2021

Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease

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7 January 2021

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

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7 January 2021

The importance of inflammatory mechanisms in Alzheimer disease.

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7 January 2021

Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles

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7 January 2021

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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7 January 2021

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

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7 January 2021

Nerve growth factor affects 11C-nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (case report).

1 reference

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7 January 2021

Delayed behavioral effects following intrahippocampal injection of aggregated A beta (1-42).

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7 January 2021

Association of diabetes mellitus and dementia: the Rotterdam Study.

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7 January 2021

Amnesic properties of scopolamine and brain acetylcholine in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain?

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part II.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Effect of metrifonate on extracellular brain acetylcholine and object recognition in aged rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Beta(1-40) amyloid peptide injection into the nucleus basalis of rats induces microglia reaction and enhances cortical gamma-aminobutyric acid release in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Transgenic animals relevant to Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Glial cytokines as neuropathogenic factors in HIV infection: pathogenic similarities to Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Prevalence of chronic diseases in older Italians: comparing self- reported and clinical diagnoses. The Italian Longitudinal Study on Aging Working Group

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7 January 2021

Single and multiple transgenic mice as models for Alzheimer's disease

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7 January 2021

The cause of neuronal degeneration in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Behavioral, biochemical, histological, and electrophysiological effects of 192 IgG-saporin injections into the basal forebrain of rats

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Pathological and biochemical consequences of acute and chronic neuroinflammation within the basal forebrain cholinergic system of rats

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900146-4

7 January 2021

10.1016/S0278-5846(01)00146-4

Identifiers

DOI

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31 July 2017

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