(Q34195332)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20443002%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20443002%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

1 reference

1

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1 February 2020

author name string

Julie L Eiseman

2

1 reference

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1 February 2020

Judith A Gilbert

3

1 reference

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1 February 2020

Julianne L Holleran

4

1 reference

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1 February 2020

Archibong E Yellow-Duke

5

1 reference

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1 February 2020

Dana M Clausen

6

1 reference

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1 February 2020

David Z D'Argenio

7

1 reference

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1 February 2020

Matthew M Ames

8

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1 February 2020

Pamela A Hershberger

9

1 reference

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1 February 2020

Robert A Parise

10

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1 February 2020

Lihua Bai

11

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1 February 2020

Joseph M Covey

12

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1 February 2020

Merrill J Egorin

13

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1 February 2020

language of work or name

1 reference

5 May 2010

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Cancer Chemotherapy and Pharmacology

1 February 2020

published in

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1 February 2020

volume

67

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1 February 2020

issue

2

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1 February 2020

page(s)

421-430

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https://scigraph.springernature.com/pub.10.1007/s00280-010-1337-6

1 February 2020

exact match

0 references

cites work

Plasma pharmacokinetics and oral bioavailability of 3,4,5,6-tetrahydrouridine, a cytidine deaminase inhibitor, in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954253

Quantitative determination of the cytidine deaminase inhibitor tetrahydrouridine (THU) in mouse plasma by liquid chromatography/electrospray ionization tandem mass spectrometry

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954253

Inhibitors of DNA methylation: beyond myelodysplastic syndromes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954253

DNA methyltransferase inhibitors and the development of epigenetic cancer therapies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954253

Phase I and pharmacologic study of PN401 and fluorouracil in patients with advanced solid malignancies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954253

New antimetabolites in cancer chemotherapy and their clinical impact

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954253

Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954253

Distribution of tetrahydrouridine in experimental animals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954253

Pharmacological studies of neurotoxicity in patients with psoriasis treated with azaribine, utilizing high-pressure liquid chromatography

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954253

Distribution of [3H]cytosine arabinoside and its products in mice, dogs, and monkeys and effect of tetrahydrouridine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954253

Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954253

Enhancement by tetrahydrouridine (NSC-112907) of the oral activity of 5-azacytidine (NSC-102816) in L1210 leukemic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954253

Modulation of gemcitabine (2',2'-difluoro-2'-deoxycytidine) pharmacokinetics, metabolism, and bioavailability in mice by 3,4,5,6-tetrahydrouridine.

5 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00280-010-1337-6

Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00280-010-1337-6

Phase II trial of PN401, 5-FU, and leucovorin in unresectable or metastatic adenocarcinoma of the stomach: a Southwest Oncology Group study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00280-010-1337-6

Analytical and pharmacokinetic studies with 5-chloro-2'-deoxycytidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00280-010-1337-6

5-Fluorouracil dose escalation enabled with PN401 (triacetyluridine): toxicity reduction and increased antitumor activity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00280-010-1337-6

Gemcitabine pharmacogenomics: cytidine deaminase and deoxycytidylate deaminase gene resequencing and functional genomics

21 January 2018

1 reference

12 December 2020

Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice

1 reference

12 December 2020

Enhancement by tetrahydrouridine of 1-beta-D-arabinofuranosylcytosine (cytarabine) oral activity in L1210 leukemic mice

1 reference

12 December 2020

Tetrahydrouridine: Physiologic disposition and effect upon deamination of cytosine arabinoside in man

1 reference

12 December 2020

Clinical Pharmacology of Tetrahydrouridine

1 reference

12 December 2020

Comparison of the bioavailability of uridine in mice after either oral or parenteral administration

1 reference

12 December 2020

Effect of tetrahydrouridine on the clinical pharmacology of 1-beta-D-arabinofuranosylcytosine when both drugs are coinfused over three hours

1 reference

12 December 2020

Clinical and pharmacologic study of orally administered uridine

1 reference

12 December 2020

Therapy of refractory/relapsed acute myeloid leukemia and blast crisis of chronic myeloid leukemia with the combination of cytosine arabinoside, tetrahydrouridine, and carboplatin

1 reference

12 December 2020

Five-chlorodeoxycytidine and biomodulators of its metabolism result in fifty to eighty percent cures of advanced EMT-6 tumors when used with fractionated radiation

1 reference

12 December 2020

5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2',3',5'-tri-O-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration. Implications for chemotherapy

1 reference

12 December 2020

Buffer capacities of human blood and plasma

1 reference

12 December 2020

Pharmacological and clinical studies with triacetyl 6-azauridine

1 reference

12 December 2020

Clinical and pharmacological studies with 2',3',5'-triacetyl-6-azauridine

1 reference

12 December 2020

10.1007/S00280-010-1337-6

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20443002%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20443002%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

20443002

1 reference