(Q34197259)

31 July 2017

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title

Metabolic engineering of beta-lactam production (English)

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31 July 2017

2

1 reference

31 July 2017

Jette Thykaer

1

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31 July 2017

1 January 2003

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31 July 2017

Metabolic Engineering

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31 July 2017

5

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31 July 2017

56-69

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31 July 2017

1

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Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein.

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Purification to homogeneity and characterization of acyl coenzyme A:6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

The isopenicillin-N acyltransferase of Penicillium chrysogenum has isopenicillin-N amidohydrolase, 6-aminopenicillanic acid acyltransferase and penicillin amidase activities, all of which are encoded by the single penDE gene

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Toward a science of metabolic engineering

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

N-terminal amino acid sequence and some properties of isopenicillin-N synthetase from Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

A coupled enzyme assay for isopenicillin N synthetase

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Isolation and partial characterisation of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Large amplification of a 35-kb DNA fragment carrying two penicillin biosynthetic genes in high penicillin producing strains of Penicillium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

The carbamoylation of the 3-hydroxymethyl group of 7alpha-methoxy-7beta-(5-D-aminoadipamido)-3-hydroxymethylceph-3-em-4-carboxylic acid (desacetyl-7alpha-methoxycephalosporin C) by homogenates of Streptomyces clavuligerus [proceedings]

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

An adenosine triphosphate-dependent carbamoylphosphate-3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Association of 6-oxo-piperidine-2-carboxylic acid with penicillin V. Production on Penicillium chrysogenum fermentations

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Probing the performance limits of the Escherichia coli metabolic network subject to gene additions or deletions

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Cellular and metabolic engineering. An overview

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Isolation of deacetoxycephalosporin C from fermentation broths of Penicillium chrysogenum transformants: construction of a new fungal biosynthetic pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Cloning and expression of the isopenicillin N synthetase gene from Penicillium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Overexpression of the lat gene in Nocardia lactamdurans from strong heterologous promoters results in very high levels of lysine-6-aminotransferase and up to two-fold increase in cephamycin C production

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Metabolic network analysis of Penicillium chrysogenum using (13)C-labeled glucose

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Reciprocal 13C-labeling: a method for investigating the catabolism of cosubstrates

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Metabolic characterization of high- and low-yielding strains of Penicillium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Continuous cultivation of Penicillium chrysogenum. Growth on glucose and penicillin production

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Characterization of the cefF gene of Nocardia lactamdurans encoding a 3'-methylcephem hydroxylase different from the 7-cephem hydroxylase

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

A two-protein component 7 alpha-cephem-methoxylase encoded by two genes of the cephamycin C cluster converts cephalosporin C to 7-methoxycephalosporin C.

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Characterization of the cmcH genes of Nocardia lactamdurans and Streptomyces clavuligerus encoding a functional 3'-hydroxymethylcephem O-carbamoyltransferase for cephamycin biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Characterization and expression in Streptomyces lividans of cefD and cefE genes from Nocardia lactamdurans: the organization of the cephamycin gene cluster differs from that in Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

The cephamycin biosynthetic genes pcbAB, encoding a large multidomain peptide synthetase, and pcbC of Nocardia lactamdurans are clustered together in an organization different from the same genes in Acremonium chrysogenum and Penicillium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity.

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

The beta-lactam antibiotics: past, present, and future

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Recombinant microorganisms for industrial production of antibiotics.

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Copurification and characterization of deacetoxycephalosporin C synthetase/hydroxylase from Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Behaviour of tritium-labelled isopenicillin N and 6-aminopenicillanic acid as potential penicillin precursors in an extract of Penicillum chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Metabolic control analysis: a survey of its theoretical and experimental development

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

1 reference

7 January 2021

The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Kinetic studies on the carboxylation of 6-amino-penicillanic acid to 8-hydroxy-penillic acid

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Growth energetics and metabolic fluxes in continuous cultures of Penicillium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Construction of a 7-aminocephalosporanic acid (7ACA) biosynthetic operon and direct production of 7ACA in Acremonium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Conversion of isopenicillin N into penicillin N in cell-free extracts of Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Purification of isopenicillin N synthetase from Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Deacetoxycephalosporin C synthetase and deacetoxycephalosporin C hydroxylase are two separate enzymes in Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Metabolic flux distributions in Penicillium chrysogenum during fed-batch cultivations

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Analysis of penicillin V biosynthesis during fed-batch cultivations with a high-yielding strain of Penicillium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Production of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine by entrapped ACV-synthetase from Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Penicillin biosynthesis: energy requirement for tripeptide precursor formation by delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Acremonium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Metabolic engineering of cephalosporin biosynthesis in Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

A nonribosomal system of peptide biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Conversion of penicillin N to cephalosporin(s) by cell-free extracts of Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Cell-free conversion of δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine into an antibiotic with the properties of isopenicillin N in Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Cloning and sequencing of the beta-lactam hydroxylase gene (cefF) from Streptomyces clavuligerus: gene duplication may have led to separate hydroxylase and expandase activities in the actinomycetes

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Cloning, characterization, and expression in Escherichia coli of the Streptomyces clavuligerus gene encoding deacetoxycephalosporin C synthetase.

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Recent advances in the structure and function of isopenicillin N synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Studies on the ring-cyclization and ring-expansion enzymes of beta-lactam biosynthesis in Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Purification and characterization of the isopenicillin N epimerase from Nocardia lactamdurans

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Cloning and nucleotide sequence determination of the isopenicillin N synthetase gene from Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Effect of exogenous lysine on the expression of early cephamycin C biosynthetic genes and antibiotic production in Nocardia lactamdurans MA4213.

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Biosynthesis and molecular genetics of cephamycins. Cephamycins produced by actinomycetes

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Precursor flux control through targeted chromosomal insertion of the lysine epsilon-aminotransferase (lat) gene in cephamycin C biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

New aspects of genes and enzymes for beta-lactam antibiotic biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Cloning, characterization, and use in strain improvement of the Cephalosporium acremonium gene cefG encoding acetyl transferase

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Cloning and disruption of the cefG gene encoding acetyl coenzyme A: deacetylcephalosporin C o-acetyltransferase from Acremonium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Cloning, characterization of the acyl-CoA:6-amino penicillanic acid acyltransferase gene of Aspergillus nidulans and linkage to the isopenicillin N synthase gene

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Analysis of a commercially improved Penicillium chrysogenum strain series: involvement of recombinogenic regions in amplification and deletion of the penicillin biosynthesis gene cluster

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Metabolic engineering: techniques for analysis of targets for genetic manipulations

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

The role of metabolic engineering in the production of secondary metabolites

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Metabolic engineering

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Metabolic control analysis of the penicillin biosynthetic pathway in a high-yielding strain of Penicillium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Incorporation of 3H from δ-(l-α-amino (4,5-3H)adipyl)-l-cysteinyl-d-(4,4-3H)valine into isopenicillin N

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Purification of isopenicillin N synthetase

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Pathway kinetics and metabolic control analysis of a high-yielding strain ofPenicillium chrysogenum during fed batch cultivations

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Molecular biology of penicillin and cephalosporin biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Cloning and characterization of the isopenicillin N synthetase gene mediating the formation of the beta-lactam ring in Aspergillus nidulans.

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Isopenicillin N synthetase of Penicillium chrysogenum, an enzyme that converts delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N.

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Growth yields and morphological characterization

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Physiological characterisation of Penicillium chrysogenum strains expressing the expandase gene from Streptomyces clavuligerus during batch cultivations. Growth and adipoyl-7-aminodeacetoxycephalosporanic acid production

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Isolation, sequence determination and expression in Escherichia coli of the isopenicillin N synthetase gene from Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Partial purification and catalytic properties of a bifunctional enzyme in the biosynthetic pathway of beta-lactams in Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

An electrophoretic molecular karyotype for an industrial strain of Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Cloning and heterologous expression of the penicillin biosynthetic gene cluster from penicillum chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Amplification of the isopenicillin N synthetase gene in a strain of Penicillium chrysogenum producing high levels of penicillin

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Quantitative analysis of Penicillium chrysogenum Wis54-1255 transformants overexpressing the penicillin biosynthetic genes

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Purification and characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Metabolic network analysis of an adipoyl-7-ADCA-producing strain of Penicillium chrysogenum: elucidation of adipate degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Localization of the lysine epsilon-aminotransferase (lat) and delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase (pcbAB) genes from Streptomyces clavuligerus and production of lysine epsilon-aminotransferase activity in Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Purification and properties of isopenicillin N epimerase from Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Application of metabolic flux analysis for the identification of metabolic bottlenecks in the biosynthesis of penicillin-G

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Environmentally safe production of 7-aminodeacetoxycephalosporanic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum.

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Cloning and expression in Escherichia coli of isopenicillin N synthetase genes from Streptomyces lipmanii and Aspergillus nidulans

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Stoichiometry of oxygen consumption in the biosynthesis of isopenicillin from a tripeptide

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

13C metabolic flux analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Purification and characterization of cephalosporin 7α-hydroxylase from Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Cloning of a Streptomyces clavuligerus DNA fragment encoding the cephalosporin 7 alpha-hydroxylase and its expression in Streptomyces lividans

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

Biochemical studies on the activity of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7176%2803%2900003-X

7 January 2021

10.1016/S1096-7176(03)00003-X

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

12749845