(Q34201433)

31 July 2017

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title

The impact of drug-induced QT interval prolongation on drug discovery and development (English)

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31 July 2017

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Bernard Fermini

1

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31 July 2017

Anthony A Fossa

series ordinal

2

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31 July 2017

language of work or name

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1 June 2003

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Nature Reviews Drug Discovery

31 July 2017

published in

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31 July 2017

volume

2

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31 July 2017

issue

6

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31 July 2017

page(s)

439-447

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A plethora of mechanisms in the HERG-related long QT syndrome. Genetics meets electrophysiology

31 July 2017

cites work

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Cellular mechanisms underlying the long QT syndrome.

31 March 2020

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Risks of non-sedating antihistamines

31 March 2020

1 reference

Torsade de pointes due to quinidine: observations in 31 patients

31 March 2020

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Pharmacokinetic and pharmacodynamic effects of high-dose continuous intravenous verapamil infusion: clinical experience in the intensive care unit

31 March 2020

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Verapamil-induced polymorphous ventricular tachycardia

31 March 2020

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Drug-induced prolongation of the QT interval: regulatory dilemmas and implications for approval and labelling of a new chemical entity

31 March 2020

1 reference

Cardiotoxic effect with convulsions in terfenadine overdose

31 March 2020

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HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine

31 March 2020

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A structural basis for drug-induced long QT syndrome

31 March 2020

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High throughput ion-channel pharmacology: planar-array-based voltage clamp

31 March 2020

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Identification of a specific radioligand for the cardiac rapidly activating delayed rectifier K+ channel

31 March 2020

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[3H]dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel?

31 March 2020

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Cell-based assays and instrumentation for screening ion-channel targets

31 March 2020

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The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis

31 March 2020

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Effects of sparfloxacin, grepafloxacin, moxifloxacin, and ciprofloxacin on cardiac action potential duration

31 March 2020

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Drugs that prolong QT interval as an unwanted effect: assessing their likelihood of inducing hazardous cardiac dysrhythmias

31 March 2020

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

31 March 2020

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Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents

31 March 2020

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Fluoxetine-induced QTU interval prolongation, T wave alternans and syncope

31 March 2020

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Fluoxetine (Prozac) as a cause of QT prolongation

31 March 2020

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31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1108

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Dimensions Publication ID

31 July 2017

1021233112

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Fatcat ID

release_rihqgaatzveoxc3gksm54lr43e

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Fatcat

https://api.fatcat.wiki/v0/release/rihqgaatzveoxc3gksm54lr43e

mapped directly with Wikidata item

24 November 2022

based on heuristic

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