(Q34207241)

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The development of the bradykinin agonist labradimil as a means to increase the permeability of the blood-brain barrier: from concept to clinical evaluation

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scholarly article

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

The development of the bradykinin agonist labradimil as a means to increase the permeability of the blood-brain barrier: from concept to clinical evaluation (English)

1 reference

Europe PubMed Central

31 July 2017

blood–brain barrier

1 reference

based on heuristic

inferred from title

author name string

Emerich DF

1

1 reference

Europe PubMed Central

31 July 2017

Dean RL

2

1 reference

Europe PubMed Central

31 July 2017

Osborn C

3

1 reference

Europe PubMed Central

31 July 2017

Bartus RT

4

1 reference

Europe PubMed Central

31 July 2017

publication date

1 January 2001

1 reference

Europe PubMed Central

31 July 2017

Clinical Pharmacokinetics

1 reference

Europe PubMed Central

31 July 2017

40

1 reference

Europe PubMed Central

31 July 2017

2

1 reference

Europe PubMed Central

31 July 2017

105-123

1 reference

Europe PubMed Central

31 July 2017

https://scigraph.springernature.com/pub.10.2165/00003088-200140020-00003

0 references

Bradykinin selectively opens blood-tumor barrier in experimental brain tumors.

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200140020-00003

21 January 2018

Bradykinin receptors of cerebral microvessels stimulate phosphoinositide turnover.

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200140020-00003

21 January 2018

Assumptions in the radiotherapy of glioblastoma

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200140020-00003

21 January 2018

An inbred colony of oncogene transgenic mice: diversity of tumours and potential as a therapeutic model

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200140020-00003

21 January 2018

Bradykinin modulation of tumor vasculature: I. Activation of B2 receptors increases delivery of chemotherapeutic agents into solid peripheral tumors, enhancing their efficacy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intravenous carboplatin for recurrent malignant glioma: a phase II study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracarotid infusion of RMP-7, a bradykinin analog: a method for selective drug delivery to brain tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central analgesic actions of loperamide following transient permeation of the blood brain barrier with Cereport (RMP-7).

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unlocking the blood-brain barrier: a role for RMP-7 in brain tumor therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intra-arterial administration of carboplatin and the blood brain barrier permeabilizing agent, RMP-7: a toxicologic evaluation in swine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinin receptor subtypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AN IN VIVO ESTIMATION OF THE POTENCIES AND HALF-LIVES OF SYNTHETIC BRADYKININ AND KALLIDIN

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New selective agonists for neurokinin receptors: pharmacological tools for receptor characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genes expressed in human tumor endothelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro plasma metabolism of RMP-7.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of bradykinin on permeability and diameter of pial vessels in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The blood-brain barrier as a target for pharmacological modulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RMP-7 : Potential as an Adjuvant to the Drug Treatment of Brain Tumours.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracarotid infusion of bradykinin selectively increases blood-tumor permeability in 9L and C6 brain tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of bradykinin in the vascular permeability response induced by carrageenin in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Controlled modulation of BBB permeability using the bradykinin agonist, RMP-7.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioregulation of kinins: kallikreins, kininogens, and kininases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I study of intravenous RMP-7 with carboplatin in patients with progression of malignant glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of beta 1-receptors for kinins in the rabbit by a bacterial lipopolysaccharide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Teniposide sometimes effective in brain metastases from non-small cell lung cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology of bradykinin and related kinins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The chemotherapy of high-grade astrocytomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that Cereport's ability to increase permeability of rat gliomas is dependent upon extent of tumor growth: implications for treating newly emerging tumor colonies

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological modification of bradykinin induced breakdown of the blood-brain barrier.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The degradation of bradykinin (BK) and of des-Arg9-BK in plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced delivery of carboplatin into brain tumours with intravenous Cereport (RMP-7): dramatic differences and insight gained from dosing parameters

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bradykinin modulation of tumor vasculature: II. activation of nitric oxide and phospholipase A2/prostaglandin signaling pathways synergistically modifies vascular physiology and morphology to enhance delivery of chemotherapeutic agents to tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced cytokines delivery and intercellular adhesion molecule 1 (ICAM-1) expression in glioma by intracarotid infusion of bradykinin analog, RMP-7.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathway across blood-brain barrier opened by the bradykinin agonist, RMP-7.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intravenous cereport (RMP-7) enhances delivery of hydrophilic chemotherapeutics and increases survival in rats with metastatic tumors in the brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociation of blood-brain barrier permeability and the hypotensive effects of the bradykinin B2 agonist, RMP-7

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced delivery of boronophenylalanine for neutron capture therapy of brain tumors using the bradykinin analog Cereport (Receptor-Mediated Permeabilizer-7).

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II studies of RMP-7 and carboplatin in the treatment of recurrent high grade glioma. RMP-7 European Study Group.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity studies of bradykinin and related peptides. B2-receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intravenous cereport (RMP-7) modifies topographic uptake profile of carboplatin within rat glioma and brain surrounding tumor, elevates platinum levels, and enhances survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of bradykinin on pial arteries and arterioles in vitro and in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some old and some new ideas on kinin metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Teniposide for brain metastases of small-cell lung cancer: a phase II study. European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrovascular effects of the bradykinin analog RMP-7 in normal and irradiated dog brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of peptidases in bradykinin-induced increase in vascular permeability in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intra-arterial Cereport (RMP-7) and carboplatin: a dose escalation study for recurrent malignant gliomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression cloning of a human B1 bradykinin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permeability of the blood brain barrier by the bradykinin agonist, RMP-7: evidence for a sensitive, auto-regulated, receptor-mediated system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bradykinin and inflammatory pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced tumor uptake of carboplatin and survival in glioma-bearing rats by intracarotid infusion of bradykinin analog, RMP-7.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Effect of Cellular Microenvironment on Vessels in the Brain. Part 1: Vessel Structure in Tumour, Peritumour and Brain from Humans with Malignant Glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bradykinin analog RMP-7 increases intracellular free calcium levels in rat brain microvascular endothelial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracarotid infusion of RMP-7, a bradykinin analog, and transport of gallium-68 ethylenediamine tetraacetic acid into human gliomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intravenous RMP-7 selectively increases uptake of carboplatin into rat brain tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11286321

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003088-200140020-00003

1 reference

Europe PubMed Central

31 July 2017

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0 references

1 reference

Europe PubMed Central

31 July 2017

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