(Q34212336)

PubMed publication ID

31 July 2017

1 reference

title

Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741650&resulttype=core&format=json

12 May 2020

author name string

Naheed R Mirza

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741650&resulttype=core&format=json

12 May 2020

Dan Peters

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741650&resulttype=core&format=json

12 May 2020

Robin G Sparks

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741650&resulttype=core&format=json

12 May 2020

publication date

1 January 2003

1 reference

PubMed publication ID

12847557

CNS Neuroscience & Therapeutics

31 July 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741650&resulttype=core&format=json

12 May 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741650&resulttype=core&format=json

12 May 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741650&resulttype=core&format=json

12 May 2020

page(s)

159-186

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741650&resulttype=core&format=json

Behavioural problems associated with dementia: the role of newer antipsychotics

12 May 2020

cites work

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12 December 2020

Potential role of muscarinic receptors in schizophrenia

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12 December 2020

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Cholinergic aspects of schizophrenia

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In vitro characterisation of the muscarinic receptor partial agonist, sabcomeline, in rat cortical and heart membranes

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12 December 2020

Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry

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12 December 2020

Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor

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12 December 2020

The binding of [3H]AF-DX 384 is reduced in the caudate-putamen of subjects with schizophrenia

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The effects of metrifonate on the cognitive, behavioral, and functional performance of Alzheimer's disease patients. Metrifonate Study Group.

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Role of accumbens and cortical dopamine receptors in the regulation of cortical acetylcholine release

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Arachidonic acid release in cell lines transfected with muscarinic receptors: a simple functional assay to determine response of agonists

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12 December 2020

Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats

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12 December 2020

Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice

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12 December 2020

Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia

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The preclinical pharmacological profile of WAY-132983, a potent M1 preferring agonist

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Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies

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12 December 2020

Activation of the mesocorticolimbic dopaminergic system by stimulation of muscarinic cholinergic receptors in the ventral tegmental area

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12 December 2020

Cortical cholinergic inputs mediating arousal, attentional processing and dreaming: differential afferent regulation of the basal forebrain by telencephalic and brainstem afferents

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Muscarinic1 and 2 receptor mRNA in the human caudate-putamen: no change in m1 mRNA in schizophrenia.

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12 December 2020

Muscarinic cholinergic modulation of prepulse inhibition of the acoustic startle reflex

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Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice.

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12 December 2020

Decreased muscarinic receptor binding in subjects with schizophrenia: a study of the human hippocampal formation.

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12 December 2020

Repeated pretreatment with amphetamine sensitizes increases in cortical acetylcholine release.

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12 December 2020

Laterodorsal tegmental stimulation elicits dopamine efflux in the rat nucleus accumbens by activation of acetylcholine and glutamate receptors in the ventral tegmental area

1 reference

12 December 2020

Brain-stimulation reward thresholds raised by an antisense oligonucleotide for the M5 muscarinic receptor infused near dopamine cells.

1 reference

12 December 2020

Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor agonists sabcomeline and xanomeline.

1 reference

12 December 2020

Effects of olanzapine and other antipsychotic agents on responding maintained by a conflict schedule

1 reference

12 December 2020

Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean.

1 reference

12 December 2020

The muscarinic agonist xanomeline increases monoamine release and immediate early gene expression in the rat prefrontal cortex

1 reference

12 December 2020

Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: a study of Brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment

1 reference

12 December 2020

M5 muscarinic receptors are needed for slow activation of dopamine neurons and for rewarding brain stimulation

1 reference

12 December 2020

Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor.

1 reference

12 December 2020

Therapeutic opportunities from muscarinic receptor research

1 reference

12 December 2020

The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat.

1 reference

12 December 2020

Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice

1 reference

12 December 2020

Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice

1 reference

12 December 2020

Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice.

1 reference

12 December 2020

Antibodies against cerebral M1 cholinergic muscarinic receptor from schizophrenic patients: molecular interaction

1 reference

12 December 2020

Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial

1 reference

12 December 2020

The inhibition of the conditioned response and the counteraction of schizophrenia by muscarinic stimulation of the brain.

1 reference

12 December 2020

Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis

1 reference

12 December 2020

Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines

1 reference

12 December 2020

Projections from the nucleus accumbens to cholinergic neurons of the ventral pallidum: a correlated light and electron microscopic double-immunolabeling study in rat

1 reference

12 December 2020

Dopamine release and metabolism in the rat frontal cortex, nucleus accumbens, and striatum: a comparison of acute clozapine and haloperidol

1 reference

12 December 2020

Cholinergic stimulation of substantia nigra: abolition of carbachol-induced eating by unilateral 6-hydroxydopamine lesion of nigrostriatal dopamine neurones

1 reference

12 December 2020

Cholinergic systems in mammalian brain and spinal cord

1 reference

12 December 2020

Cholinergic stimulation of substantia nigra: effects on feeding, drinking and sexual behaviour in the male rat

1 reference

12 December 2020

Effects of drugs on punished behavior: pre-clinical test for anxiolytics

1 reference

12 December 2020

Antagonist binding profiles of five cloned human muscarinic receptor subtypes

1 reference

12 December 2020

Animal models of anxiety based on classical conditioning: the conditioned emotional response (CER) and the fear-potentiated startle effect

1 reference

12 December 2020

Muscarine depolarizes rat substantia nigra zona compacta and ventral tegmental neurons in vitro through M1-like receptors.

1 reference

12 December 2020

Differential effects of atropine, procaine and dopamine in the rat ventral tegmentum on lateral hypothalamic rewarding brain stimulation.

1 reference

12 December 2020

Nicotinic excitation of rat ventral tegmental neurones in vitro studied by intracellular recording

1 reference

12 December 2020

Scopolamine modulates apomorphine-induced behavior in rats treated with haloperidol or SCH 23390

1 reference

12 December 2020

Clozapine in treatment-resistant schizophrenics

1 reference

12 December 2020

Facilitation of amphetamine-induced rotation by muscarinic antagonists is correlated with M2 receptor affinity

1 reference

12 December 2020

A novel class of conformationally restricted heterocyclic muscarinic agonists

1 reference

12 December 2020

Antagonistic Effects of Physostigmine and Methylphenidate in Man

1 reference

12 December 2020

Sernyl, ditran, and their antagonists: succinate and THA

1 reference

12 December 2020

Ditran and its antagonists in a mixed psychiatric population.

1 reference

12 December 2020

Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons

1 reference

12 December 2020

Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine Neurons

1 reference

12 December 2020

Prestimulus effects on human startle reflex in normals and schizophrenics

1 reference

12 December 2020

Physostigmine and lithium response in the schizophrenias

1 reference

12 December 2020

Parkinson disease, dementia, and Alzheimer disease: clinicopathological correlations.

1 reference

12 December 2020

Mesopontine neurons in schizophrenia

1 reference

12 December 2020

Catalepsy as a rodent model for detecting antipsychotic drugs with extrapyramidal side effect liability

1 reference

12 December 2020

The utility of salivary amylase as an evaluation of M3 muscarinic agonist activity in Alzheimer's disease

1 reference

12 December 2020

Determination of xanomeline and active metabolite, N-desmethylxanomeline, in human plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.

1 reference

12 December 2020

Acetylcholine and memory

1 reference

12 December 2020

Role of tegmental cholinergic neurons in dopaminergic activation, antimuscarinic psychosis and schizophrenia

1 reference

12 December 2020

Glutamatergic and cholinergic inputs from the pedunculopontine tegmental nucleus to dopamine neurons in the substantia nigra pars compacta.

1 reference

12 December 2020

Cholinergic stimulation of rostral and caudal substantia nigra pars compacta produces opposite effects on circling behavior and striatal dopamine release measured by brain microdialysis

1 reference

12 December 2020

Seroquel (ICI 204,636) restores prepulse inhibition of acoustic startle in apomorphine-treated rats: Similarities to clozapine

1 reference

12 December 2020

Psychiatric and behavioral abnormalities in Wilson's disease

1 reference

12 December 2020

Behavioral and psychiatric symptoms associated with Huntington's disease

1 reference

12 December 2020

Clozapine is a potent and selective muscarinic M4 receptor agonist

1 reference

12 December 2020

Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors

1 reference

12 December 2020

Motor and mental aspects of acute extrapyramidal syndromes.

1 reference

12 December 2020

Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity

1 reference

12 December 2020

Inhibitory action of muscarinic agonists on neurons in the rat laterodorsal tegmental nucleus in vitro.

1 reference

12 December 2020

Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients

1 reference

12 December 2020

Modulation of dopamine efflux in the striatum following cholinergic stimulation of the substantia nigra in intact and pedunculopontine tegmental nucleus-lesioned rats.

1 reference

12 December 2020

Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain

1 reference

12 December 2020

The safety and tolerance of xanomeline tartrate in patients with Alzheimer's disease.

1 reference

12 December 2020

Acetylcholine and hallucinations: disease-related compared to drug-induced alterations in human consciousness

1 reference

12 December 2020

Scientific and ethical concerns in clinical trials in Alzheimer's patients: the bridging study

1 reference

12 December 2020

1,2,5-Thiadiazole derivatives of arecoline stimulate M1 receptors coupled to phosphoinositide turnover

1 reference

12 December 2020

Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs.

1 reference

12 December 2020

Cholinesterase inhibition in Parkinson's disease

1 reference

12 December 2020

Effects of olanzapine on regional C-Fos expression in rat forebrain.

1 reference

12 December 2020

PET study of the M1-agonists [11C]xanomeline and [11C]butylthio-TZTP in monkey and man.

1 reference

12 December 2020

Trihexyphenidyl (Artane) abuse in schizophrenic patients

1 reference

12 December 2020

Muscarinic receptors regulate striatal neuropeptide gene expression in normal and amphetamine-treated rats

1 reference

12 December 2020

The role of glutamate in the pathophysiology of Parkinson's disease

1 reference

12 December 2020

Increased striatal dopamine efflux follows scopolamine administered systemically or to the tegmental pedunculopontine nucleus.

1 reference

12 December 2020

Tremulous jaw movements produced by acute tacrine administration: possible relation to parkinsonian side effects

1 reference

12 December 2020

Effects of central muscarinic-1 receptor stimulation on blood pressure regulation

1 reference

12 December 2020

Intrastriatal injection of a muscarinic receptor agonist and antagonist regulates striatal neuropeptide mRNA expression in normal and amphetamine-treated rats

1 reference

12 December 2020

Muscarinic m4 receptor activation by some atypical antipsychotic drugs

1 reference

12 December 2020

Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease

1 reference

12 December 2020

The M5 (m5) receptor subtype: fact or fiction?

1 reference

12 December 2020

M1 receptor agonist activity is not a requirement for muscarinic antinociception.

1 reference

12 December 2020

The Neuropsychiatric Inventory: assessing psychopathology in dementia patients

1 reference

12 December 2020

The selective muscarinic agonist xanomeline improves both the cognitive deficits and behavioral symptoms of Alzheimer disease.

1 reference

12 December 2020

Novel persistent activation of muscarinic M1 receptors by xanomeline

1 reference

12 December 2020

SB 202026: a novel muscarinic partial agonist with functional selectivity for M1 receptors.

1 reference

12 December 2020

Contributions of the pedunculopontine region to normal and altered REM sleep.

1 reference

12 December 2020

Potential role of muscarinic agonists in Alzheimer's disease

1 reference

12 December 2020

Locomotion and stereotypy induced by scopolamine: contributions of muscarinic receptors near the pedunculopontine tegmental nucleus

1 reference

12 December 2020

The neuroprotective and neuronal rescue effects of (-)-deprenyl

1 reference

12 December 2020

A double-blind, controlled comparison of the novel antipsychotic olanzapine versus haloperidol or placebo on anxious and depressive symptoms accompanying schizophrenia.

1 reference

12 December 2020

On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor

1 reference

12 December 2020

Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects.

1 reference

12 December 2020

Beyond the cholinergic hypothesis: the effect of metrifonate and other cholinesterase inhibitors on neuropsychiatric symptoms in Alzheimer's disease.

1 reference

12 December 2020

Love potions and the ointment of witches: historical aspects of the nightshade alkaloids

1 reference

12 December 2020

Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity

1 reference

12 December 2020

Tremulous jaw movements in rats: a model of parkinsonian tremor.

1 reference

12 December 2020

Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation

1 reference

12 December 2020

Efficacy of xanomeline in Alzheimer disease: cognitive improvement measured using the Computerized Neuropsychological Test Battery (CNTB).

1 reference

12 December 2020

Functional effects of the muscarinic receptor agonist, xanomeline, at 5-HT1 and 5-HT2 receptors

1 reference

12 December 2020

Pharmacologic strategies for augmenting cognitive performance in schizophrenia.

1 reference

12 December 2020

Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice

1 reference

12 December 2020

10.1111/J.1527-3458.2003.TB00247.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741650&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741650&resulttype=core&format=json

12 May 2020

PubMed publication ID

12847557

1 reference