(Q34212885)

31 July 2017

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title

Irritable bowel syndrome: new agents targeting serotonin receptor subtypes (English)

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31 July 2017

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irritable bowel syndrome

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De Ponti F

1

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PubMed ID

11293643

31 July 2017

Tonini M

series ordinal

2

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31 July 2017

1 January 2001

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31 July 2017

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31 July 2017

61

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31 July 2017

3

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31 July 2017

317-332

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https://scigraph.springernature.com/pub.10.2165/00003495-200161030-00001

31 July 2017

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cites work

Drug-induced defaecation in rats: role of central 5-HT1A receptors

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00003495-200161030-00001

5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine

21 January 2018

1 reference

12 December 2020

Central modulation of rectal distension-induced blood pressure changes by alosetron, a 5-HT3 receptor antagonist.

1 reference

12 December 2020

5-HT4 receptor antagonism in irritable bowel syndrome: effect of SB-207266-A on rectal sensitivity and small bowel transit

1 reference

12 December 2020

5-Hydroxytryptamine and functional bowel disorders

1 reference

12 December 2020

New and future drugs in nerve-gut dysfunction

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12 December 2020

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12 December 2020

Role of the serotonin3 receptor in stress-induced defecation

1 reference

12 December 2020

Psychometric scores and persistence of irritable bowel after infectious diarrhoea.

1 reference

12 December 2020

Distinct 5-HT receptors mediate the peristaltic reflex induced by mucosal stimuli in human and guinea pig intestine

1 reference

12 December 2020

Differential effects of amitriptyline on perception of somatic and visceral stimulation in healthy humans.

1 reference

12 December 2020

American Gastroenterological Association medical position statement: irritable bowel syndrome

1 reference

12 December 2020

Effect of FK1052, a potent 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptor dual antagonist, on colonic function in vivo

1 reference

12 December 2020

GR 38032F (ondansetron), a selective 5HT3 receptor antagonist, slows colonic transit in healthy man.

1 reference

12 December 2020

Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro

1 reference

12 December 2020

Reduction of rectal sensitivity and post-prandial motility by granisetron, a 5 HT3-receptor antagonist, in patients with irritable bowel syndrome

1 reference

12 December 2020

The pharmacological properties of the novel selective 5-HT3 receptor antagonist, alosetron, and its effects on normal and perturbed small intestinal transit in the fasted rat.

1 reference

12 December 2020

Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel

1 reference

12 December 2020

A double-blind, randomized, placebo-controlled dose-ranging study to evaluate the efficacy of alosetron in the treatment of irritable bowel syndrome

1 reference

12 December 2020

Ten secrets for development of drugs for functional gastrointestinal diseases

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12 December 2020

Differential distribution of 5-hydroxytryptamine3 receptor in the colon between human and guinea pig.

1 reference

12 December 2020

Mediators and pharmacology of visceral sensitivity: from basic to clinical investigations

1 reference

12 December 2020

QT-interval prolongation by non-cardiac drugs: lessons to be learned from recent experience

1 reference

12 December 2020

The 5-HT(3) receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetised rat.

1 reference

12 December 2020

Imipramine decreases oesophageal pain perception in human male volunteers

1 reference

12 December 2020

Standardization of barostat procedures for testing smooth muscle tone and sensory thresholds in the gastrointestinal tract. The Working Team of Glaxo-Wellcome Research, UK

1 reference

12 December 2020

Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias

1 reference

12 December 2020

Effect of meal timing not critical for the pharmacokinetics of tegaserod (HTF 919).

1 reference

12 December 2020

The long QT syndromes: genetic basis and clinical implications

1 reference

12 December 2020

Irritable bowel syndrome: new pharmaceutical approaches to treatment

1 reference

12 December 2020

Review article: the safety and efficacy of alosetron, a 5-HT3 receptor antagonist, in female irritable bowel syndrome patients

1 reference

12 December 2020

Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial

1 reference

12 December 2020

Design of treatment trials for functional gastrointestinal disorders

1 reference

12 December 2020

Gastrointestinal prokinetic benzamides: the pharmacology underlying stimulation of motility

1 reference

12 December 2020

The effect of mosapride, a novel prokinetic, on acid reflux variables in patients with gastro-oesophageal reflux disease.

1 reference

12 December 2020

The importance of 5-hydroxytryptamine receptors in the gut.

1 reference

12 December 2020

Evidence for 5-HT7 receptors mediating relaxation of human colonic circular smooth muscle

1 reference

12 December 2020

Effect of sumatriptan, a new selective 5HT1-like agonist, on liquid gastric emptying in man

1 reference

12 December 2020

Cisapride and a structural analogue, R 76,186, are 5-hydroxytryptamine4 (5-HT4) receptor agonists on the guinea-pig colon ascendens

1 reference

12 December 2020

Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome.

1 reference

12 December 2020

Effects of a serotonin 5-HT(4) receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans

1 reference

12 December 2020

Review article: clinical pharmacology of alosetron

1 reference

12 December 2020

Alosetron does not affect the visceral perception of gastric distension in healthy subjects

1 reference

12 December 2020

SDZ HTF 919 stimulates canine colonic motility and transit in vivo

1 reference

12 December 2020

Characterization of the 5-HT receptor potentiating neuromuscular cholinergic transmission in strips of human isolated detrusor muscle

1 reference

12 December 2020

Stimulation of cyclic AMP formation in the circular smooth muscle of human colon by activation of 5-HT4-like receptors

1 reference

12 December 2020

Intestinal prokinesia by two esters of 4-amino-5-chloro-2- methoxybenzoic acid: involvement of 5-hydroxytryptamine-4 receptors and dissociation from cardiac effects in vivo.

1 reference

12 December 2020

Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans

1 reference

12 December 2020

Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers

1 reference

12 December 2020

Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals.

1 reference

12 December 2020

Differential localization of 5-HT1 receptors on myenteric and submucosal neurons

1 reference

12 December 2020

5-HT1D and 5-HT2B receptors mediate contraction of smooth muscle in human small intestine

1 reference

12 December 2020

Pharmacologic profile of (R)-5-[(1-methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H- benzimidazole hydrochloride (YM060), a potent and selective 5-hydroxytryptamine3 receptor antagonist, and its enantiomer in the isolated tissue

1 reference

12 December 2020

Differences in response to 5-HT4 receptor agonists and antagonists of the 5-HT4-like receptor in human colon circular smooth muscle

1 reference

12 December 2020

Colonic transit in man is slowed by ondansetron (GR38032F), a selective 5-hydroxytryptamine receptor (type 3) antagonist

1 reference

12 December 2020

Contribution of NK(2) tachykinin receptors to propulsion in the rabbit distal colon

1 reference

12 December 2020

Role of tachykinin NK2 receptors in normal and altered rectal sensitivity in rats

1 reference

12 December 2020

The role of psychological and biological factors in postinfective gut dysfunction

1 reference

12 December 2020

Effect of selective 5HT3 antagonist (GR 38032F) on small intestinal transit and release of gastrointestinal peptides.

1 reference

12 December 2020

Effects of alosetron on gastrointestinal transit time and rectal sensation in patients with irritable bowel syndrome.

1 reference

12 December 2020

Selective 5-hydroxytryptamine antagonism: a role in irritable bowel syndrome and functional dyspepsia?

1 reference

12 December 2020

Functional bowel disorders and functional abdominal pain

1 reference

12 December 2020

Comparison of tegaserod (HTF 919) and its main human metabolite with cisapride and erythromycin on cardiac repolarization in the isolated rabbit heart

1 reference

12 December 2020

Recombinant human neurotrophic factors accelerate colonic transit and relieve constipation in humans

1 reference

12 December 2020

Alosetron relieves pain and improves bowel function compared with mebeverine in female nonconstipated irritable bowel syndrome patients

1 reference

12 December 2020

The functional gastrointestinal disorders and the Rome II process.

1 reference

12 December 2020

Influence of sumatriptan on gastric fundus tone and on the perception of gastric distension in man

1 reference

12 December 2020

Regionally selective cholinergic stimulation by BRL 24924 in the human isolated gut.

1 reference

12 December 2020

Basic and clinical aspects of visceral hyperalgesia

1 reference

12 December 2020

Effect of amitriptyline on symptoms, sleep, and visceral perception in patients with functional dyspepsia

1 reference

12 December 2020

A 5HT3 antagonist corrects the postprandial colonic hypertonic response in carcinoid diarrhea.

1 reference

12 December 2020

Integrated modelling of the clinical pharmacokinetics of SDZ HTF 919, a novel selective 5-HT4 receptor agonist, following oral and intravenous administration

1 reference

12 December 2020

The effects of granisetron, ICS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distension

1 reference

12 December 2020

Ability of mosapride to bind to 5-HT4 receptor in the human stomach

1 reference

12 December 2020

Ondansetron reduces nausea induced by gastroduodenal stimulation without changing gastric motility

1 reference

12 December 2020

Role of impaired gastric accommodation to a meal in functional dyspepsia

1 reference

12 December 2020

Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome

1 reference

12 December 2020

Irritable bowel syndrome: a technical review for practice guideline development

1 reference

12 December 2020

Cisapride increases micturition frequency

1 reference

12 December 2020

Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential?

1 reference

12 December 2020

Review article: clinical pharmacology models of irritable bowel syndrome

1 reference

12 December 2020

5-HT1A receptor-mediated inhibition of acetylcholine release from guinea pig myenteric plexus: potential mechanisms

1 reference

12 December 2020

Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers

1 reference

12 December 2020

SB-207266: 5-HT4 receptor antagonism in human isolated gut and prevention of 5-HT-evoked sensitization of peristalsis and increased defaecation in animal models

1 reference

12 December 2020

Coexpression of 5-HT2A and 5-HT4 receptors coupled to distinct signaling pathways in human intestinal muscle cells

1 reference

12 December 2020

5-HT7 receptors: current knowledge and future prospects

1 reference

12 December 2020

Evidence for the involvement of a 5-HT4 receptor in the secretory response of human small intestine to 5-HT.

1 reference

12 December 2020

Recent advances in the pharmacology of gastrointestinal prokinetics

1 reference

12 December 2020

Drug interactions with cisapride: clinical implications

1 reference

12 December 2020

Sumatriptan, a selective 5-HT1 receptor agonist, induces a lag phase for gastric emptying of liquids in humans

1 reference

12 December 2020

Motility-modifying agents and management of disorders of gastrointestinal motility.

1 reference

12 December 2020

The guinea-pig distal colon--a sensitive preparation for the investigation of 5-HT4 receptor-mediated contractions.

1 reference

12 December 2020

Pathobiology of visceral pain: molecular mechanisms and therapeutic implications. III. Visceral afferent pathways: a source of new therapeutic targets for abdominal pain.

1 reference

12 December 2020

Intestinal gas dynamics and tolerance in humans

1 reference

12 December 2020

Hypersensitivity and hyperreactivity in the irritable bowel syndrome: An opportunity for drug discovery.

1 reference

12 December 2020

Controlled treatment trials in the irritable bowel syndrome: a critique.

1 reference

12 December 2020

Increased defecation during stress or after 5-hydroxytryptophan: selective inhibition by the 5-HT(4) receptor antagonist, SB-207266.

1 reference

12 December 2020

Serotonergic mediation of postprandial colonic tonic and phasic responses in humans

1 reference

12 December 2020

The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders

1 reference

12 December 2020

Evidence for a 5-HT3 receptor involvement in the facilitation of peristalsis on mucosal application of 5-HT in the guinea pig isolated ileum

1 reference

12 December 2020

5-HT(4) receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle

1 reference

12 December 2020

Role of nitric oxide in fasting gastric fundus tone and in 5-HT1 receptor-mediated relaxation of gastric fundus.

1 reference

12 December 2020

5-HT3 receptor involvement in descending reflex relaxation in the rabbit isolated distal colon

1 reference

12 December 2020

Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome

1 reference

12 December 2020

First pharmacokinetic-pharmacodynamic study in humans with a selective 5-hydroxytryptamine4 receptor agonist

1 reference

12 December 2020

Selective 5-hydroxytryptamine type 3 receptor antagonism with ondansetron as treatment for diarrhea-predominant irritable bowel syndrome: a pilot study

1 reference

12 December 2020

Review article: cardiac adverse effects of gastrointestinal prokinetics

1 reference

12 December 2020

Differences between 5-HT3 receptor antagonists in modulation of visceral hypersensitivity

1 reference

12 December 2020

Differential localization of 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptors in the human rectum

1 reference

12 December 2020

Alosetron, a 5-HT3 receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers

1 reference

12 December 2020

Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors.

1 reference

12 December 2020

Functional gut disorders: from motility to sensitivity disorders. A review of current and investigational drugs for their management

1 reference

12 December 2020

Evidence against an acetylcholine releasing action of cisapride in the human colon

1 reference

12 December 2020

5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HT1p receptors on sensory CGRP neurons

1 reference

12 December 2020

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12 December 2020

5-HT4 receptor antagonism potentiates inhibition of intestinal allodynia by 5-HT3 receptor antagonism in conscious rats.

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12 December 2020

Modification of visceral sensitivity and pain in irritable bowel syndrome by 5-HT3 antagonism (ondansetron)

1 reference

12 December 2020

Cisapride-induced prolongation of cardiac action potential and early afterdepolarizations in rabbit Purkinje fibres.

1 reference

12 December 2020

10.2165/00003495-200161030-00001

Identifiers

DOI

1 reference

PubMed ID

11293643

Dimensions Publication ID

31 July 2017

0 references

1 reference

PubMed ID

11293643