(Q34232579)

31 July 2017

1 reference

title

Targeting polyamines of parasitic protozoa in chemotherapy (English)

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31 July 2017

main subject

trypanothione synthetase

1 reference

GeneDB

5 February 2019

trypanothione synthetase

0 references

1 reference

1 reference

Müller S

1

1 reference

31 July 2017

Coombs GH

series ordinal

2

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31 July 2017

Walter RD

series ordinal

3

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31 July 2017

publication date

1 May 2001

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31 July 2017

published in

Trends in Parasitology

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31 July 2017

volume

17

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31 July 2017

issue

5

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31 July 2017

page(s)

242-249

1 reference

Population pharmacokinetics/toxicodynamics (PK/TD) relationship of SAM486A in phase I studies in patients with advanced cancers

31 July 2017

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7 January 2021

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7 January 2021

Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis

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7 January 2021

Measurement of the number of ornithine decarboxylase molecules in rat and mouse tissues under various physiological conditions by binding of radiolabelled alpha-difluoromethylornithine

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7 January 2021

Kinetics of S-adenosylmethionine cellular transport and protein methylation in Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense

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7 January 2021

Structural elements of ornithine decarboxylase required for intracellular degradation and polyamine-dependent regulation

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7 January 2021

Cloning of a trypanosomatid gene coding for an ornithine decarboxylase that is metabolically unstable even though it lacks the C-terminal degradation domain

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7 January 2021

Ornithine Decarboxylase Gene Deletion Mutants ofLeishmania donovani

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7 January 2021

Procyclic Trypanosoma brucei cell lines deficient in ornithine decarboxylase activity

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7 January 2021

Biochemical evidence for the presence of arginine decarboxylase activity in Trypanosoma cruzi

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7 January 2021

Diamine auxotrophy in a eukaryotic parasite

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7 January 2021

Regulation of a high-affinity diamine transport system in Trypanosoma cruzi epimastigotes

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7 January 2021

Trypanosoma cruzi has not lost its S-adenosylmethionine decarboxylase: characterization of the gene and the encoded enzyme

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7 January 2021

Trypanosoma cruzi epimastigotes lack ornithine decarboxylase but can express a foreign gene encoding this enzyme

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7 January 2021

Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages

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7 January 2021

S -ADENOSYLMETHIONINE SYNTHESIS IN LEISHMANIA INFANTUM PROMASTIGOTES

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7 January 2021

Plasmodium berghei: inhibition of the sporogonous cycle by alpha-difluoromethylornithine

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7 January 2021

Inhibitory action of alpha-difluoromethylornithine on rodent malaria (Plasmodium berghei).

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7 January 2021

Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony

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7 January 2021

Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony

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7 January 2021

In the human malaria parasite Plasmodium falciparum, polyamines are synthesized by a bifunctional ornithine decarboxylase, S-adenosylmethionine decarboxylase

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7 January 2021

The ornithine decarboxylase domain of the bifunctional ornithine decarboxylase/S-adenosylmethionine decarboxylase of Plasmodium falciparum: recombinant expression and catalytic properties of two different constructs

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7 January 2021

Polyamine biosynthesis in Cryptosporidium parvum and its implications for chemotherapy

1 reference

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7 January 2021

Lysine-69 plays a key role in catalysis by ornithine decarboxylase through acceleration of the Schiff base formation, decarboxylation, and product release steps

1 reference

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7 January 2021

X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine

1 reference

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7 January 2021

Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding

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7 January 2021

Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis

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7 January 2021

The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 A resolution reveals a novel fold

1 reference

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7 January 2021

Synthesis of spermidine and norspermidine dimers as high affinity polyamine transport inhibitors

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7 January 2021

Polyamine transport systems of Leishmania donovani promastigotes

1 reference

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7 January 2021

Putrescine and spermidine transport in Leishmania.

1 reference

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7 January 2021

Effect of polyamine depletion on macromolecular synthesis of the malarial parasite, Plasmodium falciparum, cultured in human erythrocytes

1 reference

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7 January 2021

A kinetic characterization of putrescine and spermidine uptake and export in human erythrocytes

1 reference

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7 January 2021

Characterization of simian malarial parasite (Plasmodium knowlesi)-induced putrescine transport in rhesus monkey erythrocytes. A novel putrescine conjugate arrests in vitro growth of simian malarial parasite (Plasmodium knowlesi) and cures multidrug

1 reference

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7 January 2021

2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity

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7 January 2021

In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors

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7 January 2021

Enzymes of parasite thiol metabolism as drug targets

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7 January 2021

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

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7 January 2021

Extrachromosomal, homologous expression of trypanothione reductase and its complementary mRNA in Trypanosoma cruzi.

1 reference

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7 January 2021

Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus

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7 January 2021

Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase

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7 January 2021

Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi

1 reference

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7 January 2021

New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi Trypanothione Reductase

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7 January 2021

Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series

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7 January 2021

Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornithine cure murine malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2801%2901908-0

7 January 2021

Translational regulation of ornithine decarboxylase and other enzymes of the polyamine pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4922%2801%2901908-0

7 January 2021

Methionine recycling as a target for antiprotozoal drug development

1 reference

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7 January 2021

10.1016/S1471-4922(01)01908-0

Identifiers

DOI

1 reference

31 July 2017

1 reference