(Q34238394)

English

A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

5 references

13 March 2019

24 March 2019

20 August 2019

8 September 2019

24 December 2020

A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

autism spectrum disorder

0 references

0 references

0 references

pervasive developmental disorder

5 references

13 March 2019

24 March 2019

20 August 2019

8 September 2019

20 September 2020

immune disorder

4 references

13 March 2019

24 March 2019

20 August 2019

8 September 2019

mitochondrial disease

4 references

13 March 2019

24 March 2019

20 August 2019

8 September 2019

physiological phenomenon

1 reference

20 August 2019

1 reference

8 September 2019

hazardous substances

1 reference

24 December 2020

author name string

D A Rossignol

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

R E Frye

2

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

language of work or name

0 references

publication date

6 December 2011

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1 April 2012

6 references

13 March 2019

24 March 2019

20 August 2019

8 September 2019

20 September 2020

24 December 2020

Molecular Psychiatry

7 references

Europe PubMed Central

PubMed publication ID

31 July 2017

13 March 2019

24 March 2019

20 August 2019

8 September 2019

20 September 2020

24 December 2020

17

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

389-401

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

copyright license

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

5 references

Europe PubMed Central

13 March 2019

Europe PubMed Central

24 March 2019

Europe PubMed Central

20 August 2019

Europe PubMed Central

8 September 2019

Europe PubMed Central

24 December 2020

on focus list of Wikimedia project

0 references

Practical guidelines for evaluating lead exposure in children with mental health conditions: molecular effects and clinical implications

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Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders

1 reference

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Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

1 reference

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Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains

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Mitochondrial DNA (mtDNA) and schizophrenia

1 reference

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Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia

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The role of mitochondrial dysfunction in psychiatric disease

1 reference

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Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism

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Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome

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Improving the prediction of response to therapy in autism

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Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder.

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Mercury induces inflammatory mediator release from human mast cells

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Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report

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Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, United States, 2006

1 reference

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Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: part B - behavioral results

1 reference

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6 July 2018

Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: Part A--medical results

1 reference

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Neuroinflammation in schizophrenia-related psychosis: a PET study.

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Nitrative and oxidative stress in toxicology and disease

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Mechanistic biomarkers for autism treatment

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Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients

1 reference

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Metabolic biomarkers related to energy metabolism in Saudi autistic children.

1 reference

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6 July 2018

Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Elevated immune response in the brain of autistic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Biomarkers of environmental toxicity and susceptibility in autism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Oxidative stress markers in bipolar disorder: a meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Mitochondrial involvement in psychiatric disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Proximity to point sources of environmental mercury release as a predictor of autism prevalence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children an

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Genetics evaluation for the etiologic diagnosis of autism spectrum disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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A comprehensive approach to treating autism and attention-deficit hyperactivity disorder: a prepilot study

1 reference

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6 July 2018

From inflammation to sickness and depression: when the immune system subjugates the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Autism spectrum disorders: concurrent clinical disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Mitochondrial disease: a practical approach for primary care physicians.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Maternal residence near agricultural pesticide applications and autism spectrum disorders among children in the California Central Valley

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Low blood lead levels associated with clinically diagnosed attention-deficit/hyperactivity disorder and mediated by weak cognitive control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Aluminum-induced mitochondrial dysfunction leads to lipid accumulation in human hepatocytes: a link to obesity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Effect of pioglitazone treatment on behavioral symptoms in autistic children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Developmental neurotoxicity of industrial chemicals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Immunity, neuroglia and neuroinflammation in autism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Organic mercury compounds and autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Oxidative stress in hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Microglia and neuroinflammation: a pathological perspective

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Prenatal lead exposure, delta-aminolevulinic acid, and schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

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Neurodegenerative diseases and oxidative stress

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Diabetes, oxidative stress, and antioxidants: a review

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Neuroinflammation in Alzheimer's disease and prion disease.

1 reference

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Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study

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ortho-substituted PCB95 alters intracellular calcium signaling and causes cellular acidification in PC12 cells by an immunophilin-dependent mechanism

1 reference

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6 July 2018

Immunological treatments for autism

1 reference

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6 July 2018

Role of oxidative stress in cardiovascular diseases

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6 July 2018

Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Psychiatric disorders among Egyptian pesticide applicators and formulators.

1 reference

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6 July 2018

Toxic and essential metal interactions

1 reference

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6 July 2018

Pentoxifylline: brief review and rationale for its possible use in the treatment of autism

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6 July 2018

Opioid-immune interactions in autism: behavioural and immunological assessment during a double-blind treatment with naltrexone

1 reference

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6 July 2018

Dialysable lymphocyte extract (DLyE) in infantile onset autism: a pilot study

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6 July 2018

Dysregulated immune system in children with autism: beneficial effects of intravenous immune globulin on autistic characteristics

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6 July 2018

Oxidative stress in neurotoxic effects of methylmercury poisoning.

1 reference

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6 July 2018

Low-dose naltrexone effects on plasma chemistries and clinical symptoms in autism: a double-blind, placebo-controlled study.

1 reference

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6 July 2018

A preliminary trial of ascorbic acid as supplemental therapy for autism

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6 July 2018

Cerebrospinal fluid biopterin and biogenic amine metabolites during oral R-THBP therapy for infantile autism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

6 July 2018

Case study: corticosteroid treatment of language regression in pervasive developmental disorder.

1 reference

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6 July 2018

Mitochondrial DNA deletion mutations in patients with neuropsychiatric symptoms.

1 reference

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28 October 2018

Neuroinflammation in Alzheimer's disease and major depression.

1 reference

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28 October 2018

Double-blind placebo-controlled trial of pentoxifylline added to risperidone: effects on aberrant behavior in children with autism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

28 October 2018

Metabolic biomarkers related to oxidative stress and antioxidant status in Saudi autistic children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

28 October 2018

The recovery of a child with autism spectrum disorder through biomedical interventions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

28 October 2018

A prospective study of transsulfuration biomarkers in autistic disorders

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

28 October 2018

A prospective study of mercury toxicity biomarkers in autistic spectrum disorders

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

28 October 2018

Spironolactone might be a desirable immunologic and hormonal intervention in autism spectrum disorders.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

28 October 2018

Lead induced oxidative stress and its recovery following co-administration of melatonin or N-acetylcysteine during chelation with succimer in male rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

28 October 2018

Antioxidant enzyme activities and oxidative stress in affective disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

28 October 2018

Hepatocyte lysis induced by environmental metal toxins may involve apoptotic death signals initiated by mitochondrial injury

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28 October 2018

Response to steroid therapy in autism secondary to autoimmune lymphoproliferative syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

28 October 2018

Treatment of children with autism with intravenous immunoglobulin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317062

28 October 2018

Increased oxidative stress and DNA damage in bipolar disorder: A twin-case report

1 reference

https://pubmed.ncbi.nlm.nih.gov/22143005

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arsenic-induced oxidative stress and its reversibility following combined administration of N-acetylcysteine and meso 2,3-dimercaptosuccinic acid in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22143005

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress in autism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22143005

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis in human T-cells by methyl mercury: temporal relationship between mitochondrial dysfunction and loss of reductive reserve

1 reference

https://pubmed.ncbi.nlm.nih.gov/22143005

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicity biomarkers in autism spectrum disorder: a blinded study of urinary porphyrins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22143005

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of pesticides on isolated rat hepatocytes, mitochondria, and microsomes II

1 reference

https://pubmed.ncbi.nlm.nih.gov/22143005

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrastructural and biochemical changes in renal mitochondria during chronic oral methyl mercury exposure: the relationship to renal function

1 reference

https://pubmed.ncbi.nlm.nih.gov/22143005

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/MP.2011.165

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

ResearchGate publication ID

0 references

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