(Q34246740)

31 July 2017

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title

Molecular biology of chronic myeloid leukemia. (English)

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31 July 2017

chronic myeloid leukemia

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Maru Y

1

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31 July 2017

1 April 2001

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International Journal of Hematology

31 July 2017

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31 July 2017

73

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31 July 2017

3

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31 July 2017

308-322

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https://scigraph.springernature.com/pub.10.1007/bf02981955

31 July 2017

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cites work

c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein

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12 December 2020

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

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12 December 2020

The murine AIDS virus Gag precursor protein binds to the SH3 domain of c-Abl

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12 December 2020

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome

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12 December 2020

p190 BCR-ABL mRNA is expressed at low levels in p210-positive chronic myeloid and acute lymphoblastic leukemias

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12 December 2020

Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation

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12 December 2020

Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain

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12 December 2020

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias

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12 December 2020

Absence of the human retinoblastoma gene product in the megakaryoblastic crisis of chronic myelogenous leukemia

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12 December 2020

Pleckstrin domain homology

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12 December 2020

The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.

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12 December 2020

The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells

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12 December 2020

Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells

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12 December 2020

BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice.

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12 December 2020

p210 Bcr-Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic myeloid leukaemia.

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12 December 2020

Activation of p65 NF-kappaB protein by p210BCR-ABL in a myeloid cell line (P210BCR-ABL activates p65 NF-kappaB).

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12 December 2020

Neutrophilic-chronic myeloid leukemia: a distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction)

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12 December 2020

The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl

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12 December 2020

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

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12 December 2020

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

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12 December 2020

DNA strand breaks and ADP-ribosyl transferase activation during cell differentiation

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12 December 2020

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity

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12 December 2020

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway

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12 December 2020

Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway

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12 December 2020

Typical chronic myelogenous leukemia with e19a2 junction BCR/ABL transcript

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12 December 2020

Bcr-Abl with an SH3 deletion retains the ability To induce a myeloproliferative disease in mice, yet c-Abl activated by an SH3 deletion induces only lymphoid malignancy

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12 December 2020

Mutator phenotype of BCR--ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta

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12 December 2020

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

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12 December 2020

Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant

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12 December 2020

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

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12 December 2020

Bcr and Raf form a complex in vivo via 14-3-3 proteins

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12 December 2020

A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins

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12 December 2020

Abnormal peripheral lymphocyte function in c-abl mutant mice

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12 December 2020

ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23).

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12 December 2020

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

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12 December 2020

Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation

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12 December 2020

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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12 December 2020

The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein

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12 December 2020

DNA Strand Breakage in Human Leukocytes Exposed to a Tumor Promoter, Phorbol Myristate Acetate

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12 December 2020

Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1.

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12 December 2020

The BCR gene encodes a novel serine/threonine kinase activity within a single exon

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12 December 2020

3BP-1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor-induced membrane ruffling in fibroblasts.

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12 December 2020

Effect of Bcr sequences on the cellular function of the Bcr-Abl oncoprotein.

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12 December 2020

Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt

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12 December 2020

Oncogenic activation of c-ABL by mutation within its last exon.

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12 December 2020

Regulation of Bcr-Abl-induced SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase

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12 December 2020

Cell cycle-regulated binding of c-Abl tyrosine kinase to DNA

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12 December 2020

Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation

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12 December 2020

Molecular characterization of the testis specific c-abl mRNA in mouse.

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12 December 2020

Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease?

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12 December 2020

Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues

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12 December 2020

Signaling by ABL oncogenes through cyclin D1.

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12 December 2020

Randomized comparison of busulfan and hydroxyurea in chronic myelogenous leukemia: prolongation of survival by hydroxyurea. The German CML Study Group.

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12 December 2020

Isolation of putative progenitor endothelial cells for angiogenesis

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12 December 2020

Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3

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12 December 2020

Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity

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12 December 2020

Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity

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12 December 2020

Two patients with novel BCR/ABL fusion transcripts (e8/a2 and e13/a2) resulting from translocation breakpoints within BCR exons

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12 December 2020

Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia.

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12 December 2020

P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members

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12 December 2020

Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation

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12 December 2020

Three-dimensional structure of the tyrosine kinase c-Src

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12 December 2020

Bcr: a negative regulator of the Bcr-Abl oncoprotein

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12 December 2020

A temperature sensitive p210 BCR-ABL mutant defines the primary consequences of BCR-ABL tyrosine kinase expression in growth factor dependent cells.

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12 December 2020

BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac.

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12 December 2020

Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation

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12 December 2020

Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

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12 December 2020

Involvement of the adapter protein CRKL in integrin-mediated adhesion

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12 December 2020

Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia

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12 December 2020

Acute leukaemia in bcr/abl transgenic mice

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12 December 2020

The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity

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12 December 2020

The BCR-ABL oncogene requires both kinase activity and src-homology 2 domain to induce cytokine secretion

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12 December 2020

Ras oncogene mutations are rare late stage events in chronic myelogenous leukemia

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12 December 2020

Chronic myeloid leukemia

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12 December 2020

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors

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12 December 2020

Inhibition of Bcr serine kinase by tyrosine phosphorylation

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12 December 2020

Selective induction of leukemia-associated fusion genes by high-dose ionizing radiation

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12 December 2020

Role for c-Abl tyrosine kinase in growth arrest response to DNA damage.

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12 December 2020

The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration

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12 December 2020

Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis

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12 December 2020

Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation

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12 December 2020

Adhesion to fibronectin stimulates proliferation of wild-type and bcr/abl-transfected murine hematopoietic cells

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12 December 2020

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl

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12 December 2020

Leukemia in Hiroshima atomic bomb survivors

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12 December 2020

Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells

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12 December 2020

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

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12 December 2020

Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport

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12 December 2020

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

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12 December 2020

The BCR gene recombines preferentially with Alu elements in complex BCR-ABL translocations of chronic myeloid leukaemia.

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12 December 2020

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

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12 December 2020

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation

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12 December 2020

The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.

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12 December 2020

Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress

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12 December 2020

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

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12 December 2020

BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells

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12 December 2020

Flt-1, a receptor for vascular endothelial growth factor, has transforming and morphogenic potentials.

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12 December 2020

Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases

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12 December 2020

Dimerization of cell surface receptors in signal transduction

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12 December 2020

Clonal Origin of Chronic Myelocytic Leukemia

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12 December 2020

Interference with p53 protein inhibits hematopoietic and muscle differentiation

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12 December 2020

Alternative 5' exons in c-abl mRNA.

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12 December 2020

Expression of BCR – ABL in M1 myeloid leukemia cells induces differentiation without arresting proliferation

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12 December 2020

Characterization of a novel member of the DOK family that binds and modulates Abl signaling

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12 December 2020

C-RAF-1 serine/threonine kinase is required in BCR/ABL-dependent and normal hematopoiesis

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12 December 2020

The DNA sequence of human chromosome 22

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12 December 2020

An intramolecular SH3-domain interaction regulates c-Abl activity

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12 December 2020

Differential complementation of Bcr-Abl point mutants with c-Myc

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12 December 2020

Analysis of chimeric Gag-Arg/Abl molecules indicates a distinct negative regulatory role for the Arg C-terminal domain

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12 December 2020

Phosphatidylinositol-3-OH kinase as a direct target of Ras

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12 December 2020

Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines

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12 December 2020

Chronic myelogenous leukemia--progress at the M. D. Anderson Cancer Center over the past two decades and future directions: first Emil J Freireich Award Lecture.

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12 December 2020

BCR binds to the xeroderma pigmentosum group B protein

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12 December 2020

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia

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12 December 2020

An essential role for Rac in Ras transformation

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12 December 2020

Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate

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12 December 2020

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

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12 December 2020

Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase

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12 December 2020

Genomic instability of microsatellite repeats and its association with the evolution of chronic myelogenous leukemia.

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12 December 2020

The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases

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12 December 2020

Lack of imprinting of the ABL gene

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12 December 2020

The dimerization property of glutathione S-transferase partially reactivates Bcr-Abl lacking the oligomerization domain.

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12 December 2020

Bcr/Abl associated leukemogenesis in bcr null mutant mice

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12 December 2020

An activating mutation in the ATP binding site of the ABL kinase domain.

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12 December 2020

Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck

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12 December 2020

Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia.

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12 December 2020

Deletion of the ABL SH3 domain reactivates de-oligomerized BCR-ABL for growth factor independence

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12 December 2020

Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells

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12 December 2020

Bcr encodes a GTPase-activating protein for p21rac

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12 December 2020

Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway

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12 December 2020

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

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12 December 2020

Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro

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12 December 2020

The nuclear tyrosine kinase c-Abl negatively regulates cell growth

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12 December 2020

BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis

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12 December 2020

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

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12 December 2020

The SH3 domain contributes to BCR/ABL-dependent leukemogenesis in vivo: role in adhesion, invasion, and homing

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12 December 2020

Large deletions at the t(9;22) breakpoint are common and may identify a poor-prognosis subgroup of patients with chronic myeloid leukemia

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12 December 2020

The structural basis for 14-3-3:phosphopeptide binding specificity

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12 December 2020

Dominant negative MYC blocks transformation by ABL oncogenes

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12 December 2020

p53 in chronic myelogenous leukemia in acute phase

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12 December 2020

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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12 December 2020

The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype.

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12 December 2020

Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

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12 December 2020

Chronic myelogenous leukaemia with p185(BCR/ABL) expression: characteristics and clinical significance

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12 December 2020

Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis

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12 December 2020

TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis

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12 December 2020

Bcr phosphorylated on tyrosine 177 binds Grb2

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12 December 2020

rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo

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12 December 2020

Interaction between ATM protein and c-Abl in response to DNA damage

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12 December 2020

Requirement of two specific tyrosine residues for the catalytic activity of Bcr serine/threonine kinase

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12 December 2020

A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization

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12 December 2020

Chronic myeloid leukemia with e19a2 (c3a2) BCR/ABL fusion junction--is it truly a benign disease?

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12 December 2020

The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc

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12 December 2020

An oncogenic form of the Flt-1 kinase has a tubulogenic potential in a sinusoidal endothelial cell line

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12 December 2020

Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity

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12 December 2020

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

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12 December 2020

Clonal evolution in a myeloid cell line transformed to interleukin-3 independent growth by retroviral transduction and expression of p210bcr/abl

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12 December 2020

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

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12 December 2020

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

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12 December 2020

Transgenes encoding both type I and type IV c-abl proteins rescue the lethality of c-abl mutant mice

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12 December 2020

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

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12 December 2020

Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia.

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12 December 2020

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12 December 2020

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

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12 December 2020

Identification of a binding site in c-Ab1 tyrosine kinase for the C-terminal repeated domain of RNA polymerase II.

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12 December 2020

c-abl has a sequence-specific enhancer binding activity

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12 December 2020

A novel BCR-ABL fusion gene (e6a2) in a patient with Philadelphia chromosome-negative chronic myelogenous leukemia

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12 December 2020

Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc

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12 December 2020

Regulatory mechanisms in stem cell biology

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12 December 2020

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

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12 December 2020

Protein kinase C and lipid signaling for sustained cellular responses

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12 December 2020

Acquired loss of p53 induces blastic transformation in p210(bcr/abl)-expressing hematopoietic cells: a transgenic study for blast crisis of human CML.

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12 December 2020

TFIIH: a key component in multiple DNA transactions

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12 December 2020

Expression of the normal p53 gene induces differentiation of K562 cells

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12 December 2020

The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr

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12 December 2020

Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family

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12 December 2020

Distribution of ABL and BCR genes in cell nuclei of normal and irradiated lymphocytes

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12 December 2020

Nuclear localization of v-Abl leads to complex formation with cyclic AMP response element (CRE)-binding protein and transactivation through CRE motifs

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12 December 2020

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein

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12 December 2020

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

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12 December 2020

Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases

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12 December 2020

Rational design of specific high-affinity peptide ligands for the Abl-SH3 domain

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12 December 2020

A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs

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12 December 2020

Lymphosarcoma: virus-induced thymic-independent disease in mice

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12 December 2020

The CML-specific P210 bcr/abl protein, unlike v-abl, does not transform NIH/3T3 fibroblasts

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12 December 2020

Comparative analysis of G-banding, chromosome painting, locus-specific fluorescence in situ hybridization, and comparative genomic hybridization in chronic myeloid leukemia blast crisis

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12 December 2020

Protein kinase Ciota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis

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12 December 2020

An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias

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12 December 2020

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

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12 December 2020

Differences in oncogenic potency but not target cell specificity distinguish the two forms of the BCR/ABL oncogene

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12 December 2020

The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

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12 December 2020

The SH2-containing adapter protein GRB10 interacts with BCR-ABL

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12 December 2020

Benzene and leukaemia

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12 December 2020

The ABL-BCR fusion gene is expressed in chronic myeloid leukemia

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12 December 2020

Increased neutrophil respiratory burst in bcr-null mutants

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12 December 2020

A sense-abl response?

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12 December 2020

The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization

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12 December 2020

Protein kinase CK2alpha is a target for the Abl and Bcr-Abl tyrosine kinases

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12 December 2020

Stem cell factor as a single agent induces selective proliferation of the Philadelphia chromosome positive fraction of chronic myeloid leukemia CD34(+) cells

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12 December 2020

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia

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12 December 2020

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

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12 December 2020

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

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12 December 2020

Blastic transformation of p53-deficient bone marrow cells by p210bcr/abl tyrosine kinase.

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12 December 2020

JAK-STAT signaling activated by Abl oncogenes

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12 December 2020

Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia

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12 December 2020

p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.

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12 December 2020

Identifiers

DOI

10.1007/BF02981955

1 reference

PubMed ID

11345196

Dimensions Publication ID

31 July 2017

0 references

1 reference

PubMed ID

11345196