(Q34254302)

31 July 2017

Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL. (English)

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31 July 2017

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M Leiva

1

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31 July 2017

S Moretti

2

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31 July 2017

H Soilihi

3

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31 July 2017

I Pallavicini

4

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31 July 2017

L Peres

5

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31 July 2017

C Mercurio

6

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31 July 2017

R Dal Zuffo

7

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31 July 2017

S Minucci

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31 July 2017

H de Thé

9

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31 July 2017

15 February 2012

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31 July 2017

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31 July 2017

26

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31 July 2017

1630-1637

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31 July 2017

7

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https://scigraph.springernature.com/pub.10.1038/leu.2012.39

31 July 2017

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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

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PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors

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Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL.

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Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.

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PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors

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Response to histone deacetylase inhibition of novel PML/RARalpha mutants detected in retinoic acid-resistant APL cells

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Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

21 January 2018

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Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

21 January 2018

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RXR is an essential component of the oncogenic PML/RARA complex in vivo

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inferred from DOI database lookup

7 January 2021

based on heuristic

The deacetylase inhibitor LAQ824 induces notch signalling in haematopoietic progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.39

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/LEU.2012.39

1 reference

Dimensions Publication ID

31 July 2017

0 references

1 reference