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Toward precision medicine with next-generation EGFR inhibitors in non-small-cell lung cancer.
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Europe PubMed Central
PMC publication ID
4178554
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25278773%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
review article
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Europe PubMed Central
title
Toward precision medicine with next-generation EGFR inhibitors in non-small-cell lung cancer
(English)
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stated in
Europe PubMed Central
PMC publication ID
4178554
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25278773%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
author
Sanjay Popat
series ordinal
2
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Europe PubMed Central
PMC publication ID
4178554
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25278773%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
author name string
Timothy A Yap
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4178554
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25278773%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
publication date
19 September 2014
1 reference
stated in
Europe PubMed Central
PMC publication ID
4178554
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25278773%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
published in
Pharmacogenomics and Personalized Medicine
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stated in
Europe PubMed Central
PMC publication ID
4178554
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25278773%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
volume
7
1 reference
stated in
Europe PubMed Central
PMC publication ID
4178554
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25278773%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
page(s)
285-295
1 reference
stated in
Europe PubMed Central
PMC publication ID
4178554
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25278773%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
copyright license
Creative Commons Attribution-NonCommercial 3.0 Unported
start time
1 September 2014
1 reference
stated in
April 2022 Public Data File from Crossref
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copyrighted
0 references
cites work
Dual inhibition of EGFR with afatinib and cetuximab in kinase inhibitor-resistant EGFR-mutant lung cancer with and without T790M mutations
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AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer
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Circulating tumor cells: a multifunctional biomarker
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6 July 2018
Management of acquired resistance to epidermal growth factor receptor kinase inhibitors in patients with advanced non-small cell lung cancer
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6 July 2018
Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC.
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6 July 2018
The role of afatinib in the management of non-small cell lung carcinoma
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
LUX-Lung 4: a phase II trial of afatinib in patients with advanced non-small-cell lung cancer who progressed during prior treatment with erlotinib, gefitinib, or both
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
Dacomitinib, an emerging HER-targeted therapy for non-small cell lung cancer
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PubMed Central
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6 July 2018
Resistance to irreversible EGF receptor tyrosine kinase inhibitors through a multistep mechanism involving the IGF1R pathway
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PubMed Central
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6 July 2018
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.
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Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
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6 July 2018
Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
The EGFR T790M mutation in acquired resistance to an irreversible second-generation EGFR inhibitor
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
Phase II trial of dasatinib for patients with acquired resistance to treatment with the epidermal growth factor receptor tyrosine kinase inhibitors erlotinib or gefitinib
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay
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6 July 2018
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
Detection of mutations in EGFR in circulating lung-cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
retrieved
6 July 2018
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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6 July 2018
High T790M detection rate in TKI-naive NSCLC with EGFR sensitive mutation: truth or artifact?
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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28 October 2018
Symptom control and quality of life in LUX-Lung 3: a phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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28 October 2018
Symptom and quality of life benefit of afatinib in advanced non-small-cell lung cancer patients previously treated with erlotinib or gefitinib: results of a randomized phase IIb/III trial (LUX-Lung 1).
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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28 October 2018
First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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28 October 2018
Phase I/II trial of cetuximab and erlotinib in patients with lung adenocarcinoma and acquired resistance to erlotinib.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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28 October 2018
Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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28 October 2018
Envisioning the future of early anticancer drug development.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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28 October 2018
Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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28 October 2018
Prospective assessment of discontinuation and reinitiation of erlotinib or gefitinib in patients with acquired resistance to erlotinib or gefitinib followed by the addition of everolimus.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178554
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28 October 2018
Translating cancer research into targeted therapeutics
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25278773
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.2147/PGPM.S55339
1 reference
stated in
Europe PubMed Central
PMC publication ID
4178554
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25278773%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
PMC publication ID
4178554
1 reference
stated in
Europe PubMed Central
PMC publication ID
4178554
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25278773%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
PubMed publication ID
25278773
1 reference
stated in
Europe PubMed Central
PMC publication ID
4178554
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25278773%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
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