(Q34264422)

1 August 2017

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title

Mitochondrial contributions to cancer cell physiology: potential for drug development (English)

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1 August 2017

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Preston TJ

1

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1 August 2017

Abadi A

series ordinal

2

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1 August 2017

Wilson L

series ordinal

3

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1 August 2017

Singh G

series ordinal

4

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1 August 2017

language of work or name

English

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publication date

1 July 2001

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Advanced Drug Delivery Reviews

1 August 2017

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1 August 2017

49

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1 August 2017

1-2

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1 August 2017

45-61

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Mitochondria: beyond oxidative phosphorylation

1 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Sequence and organization of the human mitochondrial genome

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Nucleo-mitochondrial interactions in mitochondrial gene expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Covalent binding of polycyclic aromatic compounds to mitochondrial and nuclear DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Evidence for lack of mitochondrial DNA repair following cis-dichlorodiammineplatinum treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Does the mitochondrial DNA play a role in the pathogenesis of diabetes?

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mitochondrial injury. Lessons from the fialuridine trial

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Genotoxicity and mitochondrial damage in human lymphocytic cells chronically exposed to 3'-azido-2',3'-dideoxythymidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

A possible cellular mechanism of cisplatin-induced nephrotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mitochondrial DNA damage by anticancer agents

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Apoptosis signaling by death receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Escaping cell death: survival proteins in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mitochondria and apoptosis: HQ or high-security prison?

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Bcl-2 family proteins and mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mitochondrial control of apoptosis: the role of cytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

The mitochondrial permeability transition pore and its role in cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Bax directly induces release of cytochrome c from isolated mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mitochondria and cell death. Mechanistic aspects and methodological issues

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

An essential role for free radicals and derived species in signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

The cellular production of hydrogen peroxide

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Activation of an H2O2-generating NADH oxidase in human lung fibroblasts by transforming growth factor beta 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Redox regulation of cellular signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Requirement for generation of H2O2 for platelet-derived growth factor signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

NF-kappaB as a primary regulator of the stress response

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Role of redox potential and reactive oxygen species in stress signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

The stress-activated protein kinase pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Functional antioxidant responsive elements.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Redox regulation of the caspases during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mitochondrial diseases in man and mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Oxidative phosphorylation at the fin de siècle

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Stable overexpression of manganese superoxide dismutase in mitochondria identifies hydrogen peroxide as a major oxidant in the AP-1-mediated induction of matrix-degrading metalloprotease-1

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Antioxidant function of the mitochondrial protein SP-22 in the cardiovascular system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mitochondrial disease in mouse results in increased oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

On the Origin of Cancer Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Somatic mutations of the mitochondrial genome in human colorectal tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Inhibition of cell growth in NIH/3T3 fibroblasts by overexpression of manganese superoxide dismutase: mechanistic studies

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Overexpression of catalase in the mitochondrial or cytosolic compartment increases sensitivity of HepG2 cells to tumor necrosis factor-alpha-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Stress signals utilize multiple pathways to stabilize p53

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Expression of hypoxia-inducible factor 1: mechanisms and consequences

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Decreased mitochondrial function in quiescent cells isolated from multicellular tumor spheroids

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Cellular respiration during hypoxia. Role of cytochrome oxidase as the oxygen sensor in hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Effects of modulators of the production and degradation of hydrogen peroxide on erythropoietin synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

ERK activation upon hypoxia: involvement in HIF-1 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Hypoxia-induced bFGF gene expression is mediated through the JNK signal transduction pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Oxidative phosphorylation enzymes in normal and neoplastic cell growth.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mutagenesis, tumorigenicity, and apoptosis: are the mitochondria involved?

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

On the tumorigenicity of mitochondrial DNA-depleted avian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Crosstalk between nuclear and mitochondrial genomes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Nuclear control of respiratory chain expression in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

The c-ets-1 proto-oncogene is a new early-response gene differentially regulated by cytokines and growth factors in human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

The alpha and beta subunits of the GA-binding protein form a stable heterodimer in solution. Revised model of heterotetrameric complex assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Regulation of mitochondrial biogenesis in brown adipose tissue: nuclear respiratory factor-2/GA-binding protein is responsible for the transcriptional regulation of the gene for the mitochondrial ATP synthase beta subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

On the role of the general transcription factor Sp1 in the activation and repression of diverse mammalian oxidative phosphorylation genes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Adaptive thermogenesis: orchestrating mitochondrial biogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Increase in intracellular hydrogen peroxide and upregulation of a nuclear respiratory gene evoked by impairment of mitochondrial electron transfer in human cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Up-regulation of nuclear genes in response to inhibition of mitochondrial DNA expression in chicken cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

NF-kappa B: ten years after

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Redox regulation of GA-binding protein-alpha DNA binding activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Upregulation of human heme oxygenase gene expression by Ets-family proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Stimulation of in vitro angiogenesis by hydrogen peroxide and the relation with ETS-1 in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

A conserved mechanism for controlling the translation of beta-F1-ATPase mRNA between the fetal liver and cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900127-2

7 January 2021

10.1016/S0169-409X(01)00127-2

Identifiers

DOI

1 reference

1 August 2017

1 reference