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Mitochondria as subcellular targets for clinically useful anthracyclines
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
11377805
retrieved
1 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Mitochondria as subcellular targets for clinically useful anthracyclines
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11377805
retrieved
1 August 2017
main subject
mitochondrion
1 reference
based on heuristic
inferred from title
author name string
Jung K
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11377805
retrieved
1 August 2017
Reszka R
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
11377805
retrieved
1 August 2017
language of work or name
English
0 references
publication date
1 July 2001
1 reference
stated in
Europe PubMed Central
PubMed ID
11377805
retrieved
1 August 2017
published in
Advanced Drug Delivery Reviews
1 reference
stated in
Europe PubMed Central
PubMed ID
11377805
retrieved
1 August 2017
volume
49
1 reference
stated in
Europe PubMed Central
PubMed ID
11377805
retrieved
1 August 2017
issue
1-2
1 reference
stated in
Europe PubMed Central
PubMed ID
11377805
retrieved
1 August 2017
page(s)
87-105
1 reference
stated in
Europe PubMed Central
PubMed ID
11377805
retrieved
1 August 2017
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Interaction of adriamycin with cardiolipin-containing vesicles. Evidence of an embedded site for the dihydroanthraquinone moiety
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Ca2+ as a second messenger within mitochondria of the heart and other tissues
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Selective activation of the sodium-independent, cyclosporin A-sensitive calcium pore of cardiac mitochondria by doxorubicin.
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Dose-dependent increase in sensitivity to calcium-induced mitochondrial dysfunction and cardiomyocyte cell injury by doxorubicin
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Role of iron in the potentiation of anthracycline cardiotoxicity: identification of heart cell mitochondria as a major site of iron-anthracycline interaction
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Oxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin-iron complex
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Diminished superoxide anion generation by reduced 5-iminodaunorubicin relative to daunorubicin and the relationship to cardiotoxicity of the anthracycline antitumor agents
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Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents
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Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation
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Chelated iron-catalyzed OH. formation from paraquat radicals and H2O2: Mechanism of formate oxidation
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Hydroxyl radical production from hydrogen peroxide and enzymatically generated paraquat radicals: Catalytic requirements and oxygen dependence
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7 January 2021
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Doxorubicin-dependent lipid peroxidation at low partial pressures of O2
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7 January 2021
based on heuristic
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Radical-driven Fenton reactions: studies with paraquat, adriamycin, and anthraquinone 6-sulfonate and citrate, ATP, ADP, and pyrophosphate iron chelates
1 reference
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Crossref
reference URL
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7 January 2021
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Reactions of the semiquinone free radicals of anti-tumour agents with oxygen and iron complexes
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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An electron paramagnetic resonance study of the interactions between the adriamycin semiquinone, hydrogen peroxide, iron-chelators, and radical scavengers
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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Possible intermediates in the action of adriamycin--a pulse radiolysis study
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
One-electron reduction of adriamycin and daunomycin: short-term stability of the semiquinones
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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Secondary alcohol metabolites mediate iron delocalization in cytosolic fractions of myocardial biopsies exposed to anticancer anthracyclines. Novel linkage between anthracycline metabolism and iron-induced cardiotoxicity
1 reference
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Crossref
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7 January 2021
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Role of quinone-iron(III) interaction in NADPH-dependent enzymatic generation of hydroxyl radicals
1 reference
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Crossref
reference URL
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7 January 2021
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A free radical scavenger role for daunomycin: inhibition of nonenzymatic oxidation of NADH
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Crossref
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7 January 2021
based on heuristic
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Spin trapping of free radical species produced during the microsomal metabolism of ethanol
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Crossref
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7 January 2021
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Mitochondrial permeability transition induced by 1-hydroxyethyl radical
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Crossref
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7 January 2021
based on heuristic
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Hydroperoxide metabolism in mammalian organs
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7 January 2021
based on heuristic
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The free radical theory of aging matures
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7 January 2021
based on heuristic
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Oxidative damage and mitochondrial decay in aging
1 reference
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Crossref
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7 January 2021
based on heuristic
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Mitochondrial diseases in man and mouse
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7 January 2021
based on heuristic
inferred from DOI database lookup
Role of mitochondria in oxidative stress and ageing
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Normal oxidative damage to mitochondrial and nuclear DNA is extensive
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
based on heuristic
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Mitochondrial decay in aging
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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Oxidants, antioxidants, and the degenerative diseases of aging
1 reference
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Crossref
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7 January 2021
based on heuristic
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Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction
1 reference
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7 January 2021
based on heuristic
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A possible role for membrane lipid peroxidation in anthracycline nephrotoxicity
1 reference
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7 January 2021
based on heuristic
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Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice
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7 January 2021
based on heuristic
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Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
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7 January 2021
based on heuristic
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The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
One-electron-transfer reactions in biochemical systems. V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase)
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
based on heuristic
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One-electron transfer reactions in biochemical systems. IV. A mixed mechanism in the reaction of milk xanthine oxidase with electron acceptors.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
based on heuristic
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Mitochondrial NADH dehydrogenase-catalyzed oxygen radical production by adriamycin, and the relative inactivity of 5-iminodaunorubicin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of Adriamycin on heart mitochondrial function in rested and exercised rats
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adriamycin stimulated superoxide formation in submitochondrial particles
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of the site of adriamycin-activation in the heart cell.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
The exogenous NADH dehydrogenase of heart mitochondria is the key enzyme responsible for selective cardiotoxicity of anthracyclines.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of 5-iminodaunorubicin on nucleoli of rats
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Protective effect of endogenous coenzyme Q on both lipid peroxidation and respiratory chain inactivation induced by an adriamycin-iron complex
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structural requirements for anthracycline-induced cardiotoxicity and antitumor effects
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of transplasma membrane electron transport by transferrin-adriamycin conjugates
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Different distribution of daunomycin in plasma membranes from drug-sensitive and drug-resistant P388 leukemia cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Role of membrane lipids in the interaction of daunomycin with plasma membranes from tumor cells: implications in drug-resistance phenomena.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adriamycin and daunomycin semiquinone membrane/buffer partition constants using the spin-broadening technique
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The interaction of daunomycin with model membranes. Effect of the lipid physical state and the lipid composition
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Further studies on the generation of reactive oxygen species from activated anthracyclines and the relationship to cytotoxic action and cardiotoxic effects
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The interaction of adriamycin with cardiolipin in model and rat liver mitochondrial membranes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence of a complex between adriamycin derivatives and cardiolipin: possible role in cardiotoxicity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fluorescent substances and high molecular weight protein aggregates formed in rat heart mitochondria upon doxorubicin-induced lipid peroxidation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Detection of Phosphatidylcholine Hydroperoxide Produced in the Heart of the Doxorubicin Administered Mouse
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Demonstration of the existence of an organo-specific NADH dehydrogenase in heart mitochondria
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oxidation of cytosolic NADH via complex I of heart mitochondria
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
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Excessive formation of hydroxyl radicals and aldehydic lipid peroxidation products in cultured skin fibroblasts from patients with complex I deficiency
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytochrome c: can't live with it--can't live without it.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
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inferred from DOI database lookup
Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
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Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
based on heuristic
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Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase-14 is a novel developmentally regulated protease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
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Mitochondrial DNA sequence variation in human evolution and disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
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Chemical determination of free radical-induced damage to DNA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
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Preferential oxidation of cardiac mitochondrial DNA following acute intoxication with doxorubicin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
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Cardioselective and cumulative oxidation of mitochondrial DNA following subchronic doxorubicin administration 1Supported in part by NIH Grant HL58016. The manuscript was not subjected to internal Agency review and, thus, the opinions are those of the
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
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7 January 2021
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Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hydroxyl radical generation during mitochondrial electron transfer and the formation of 8-hydroxydesoxyguanosine in mitochondrial DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0169-409X(01)00128-4
1 reference
stated in
Europe PubMed Central
PubMed ID
11377805
retrieved
1 August 2017
PubMed ID
11377805
1 reference
stated in
Europe PubMed Central
PubMed ID
11377805
retrieved
1 August 2017
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