(Q34272885)

1 August 2017

title

The Use of Isotope Effects to Determine Enzyme Mechanisms (English)

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https://api.crossref.org/works/10.1074/JBC.X300005200

26 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.X300005200

26 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.X300005200

26 March 2024

author name string

W. Wallace Cleland

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14583616

26 March 2024

language of work or name

English

0 references

publication date

28 October 2003

1 reference

full work available at URL

1 August 2017

http://www.jbc.org/content/278/52/51975.full.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14583616

https://api.elsevier.com/content/article/PII:S0021925820751963?httpAccept=text/xml

26 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.X300005200

https://api.elsevier.com/content/article/PII:S0021925820751963?httpAccept=text/plain

26 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.X300005200

https://syndication.highwire.org/content/doi/10.1074/jbc.X300005200

26 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.X300005200

Journal of Biological Chemistry

26 March 2024

published in

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1 August 2017

volume

278

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1 August 2017

issue

52

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1 August 2017

page(s)

51975-51984

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Kinetic and isotope-exchange studies on shikimate dehydrogenase from Pisum sativum.

1 August 2017

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Use of multiple isotope effects to determine enzyme mechanisms and intrinsic isotope effects. Malic enzyme and glucose-6-phosphate dehydrogenase.

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Determination of the rate-limiting steps for malic enzyme by the use of isotope effects and other kinetic studies

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Use of intermediate partitioning to calculate intrinsic isotope effects for the reaction catalyzed by malic enzyme.

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Use of isotope effects to deduce the chemical mechanism of fumarase.

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Kinetic and chemical mechanisms of yeast formate dehydrogenase.

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Mechanistic deductions from isotope effects in multireactant enzyme mechanisms.

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pH variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope- and pH-dependent steps the same.

21 January 2018

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pH variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase.

21 January 2018

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Use of isotope effects to elucidate enzyme mechanisms

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Use of multiple isotope effects to study the mechanism of 6-phosphogluconate dehydrogenase

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Mechanisms of enzymatic and acid-catalyzed decarboxylations of prephenate

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Use of nitrogen-15 and deuterium isotope effects to determine the chemical mechanism of phenylalanine ammonia-lyase

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Evidence from nitrogen-15 and solvent deuterium isotope effects on the chemical mechanism of adenosine deaminase.

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Carbon-13 isotope effects as a probe of the kinetic mechanism and allosteric properties of Escherichia coli aspartate transcarbamylase

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13C and deuterium isotope effects suggest an aldol cleavage mechanism for L-ribulose-5-phosphate 4-epimerase

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Heavy atom isotope effects on the reaction catalyzed by the oxalate decarboxylase from Bacillus subtilis

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Use of Hydrogen Isotope Effects to Identify the Attacking Nucleophile in the Enolization of Ketones Catalyzed by Acetic Acid1-3

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The kinetics of enzyme-catalyzed reactions with two or more substrates or products

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The kinetics of enzyme-catalyzed reactions with two or more substrates or products

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Kinetic studies of Escherichia coli galactokinase

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Kinetic study of yeast nucleosidediphosphate kinase

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Variation of transition-state structure as a function of the nucleotide in reactions catalyzed by dehydrogenases. 2. Formate dehydrogenase

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13C and (15)N kinetic isotope effects on the reaction of aspartate aminotransferase and the tyrosine-225 to phenylalanine mutant

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Steady-state kinetics and isotope effects on the mutant catalytic trimer of aspartate transcarbamoylase containing the replacement of histidine 134 by alanine

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Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction

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Determination of the chemical mechanism of malic enzyme by isotope effects

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Determination of the kinetic and chemical mechanism of malic enzyme using (2R,3R)-erythro-fluoromalate as a slow alternate substrate

21 January 2018

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Equilibrium perturbation by isotope substitution

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Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions

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Mechanisms of phosphoryl and acyl transfer

26 March 2024

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26 March 2024

Identifiers

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1 August 2017

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