(Q34274409)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607309%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607309%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607309%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Lucija Peterlin-Masic

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607309%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

author name string

Tihomir Tomašić

series ordinal

1

1 reference

1 August 2017

Lucija Peterlin Mašič

series ordinal

2

1 reference

1 August 2017

language of work or name

English

0 references

publication date

19 May 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607309%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Drug Discovery

1 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607309%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607309%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607309%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

page(s)

549-560

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607309%20AND%20SRC:MED&resulttype=core&format=json

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

1 February 2020

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Observations on screening-based research and some concerning trends in the literature

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Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry

21 January 2018

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Rhodanine as a privileged scaffold in drug discovery

21 January 2018

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Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity

21 January 2018

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The synthesis of phenylalanine-derived C5-substituted rhodanines and their activity against selected methicillin-resistant Staphylococcus aureus (MRSA) strains

21 January 2018

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Synthesis and antibacterial activity of 5-ylidenethiazolidin-4-ones and 5-benzylidene-4,6-pyrimidinediones

21 January 2018

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Challenges of antibacterial discovery

21 January 2018

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Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases

21 January 2018

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Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase.

21 January 2018

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Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligase

21 January 2018

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New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: design, synthesis, crystal structures, and biological evaluation

21 January 2018

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Structure-based design of a new series of D-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD)

21 January 2018

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Novel 2-thioxothiazolidin-4-one inhibitors of bacterial MurD ligase targeting D-Glu- and diphosphate-binding sites

21 January 2018

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Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors

21 January 2018

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Promoting assembly and bundling of FtsZ as a strategy to inhibit bacterial cell division: a new approach for developing novel antibacterial drugs.

21 January 2018

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Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase.

21 January 2018

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Design, synthesis, and structure-activity relationship of a novel series of 2-aryl 5-(4-oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl)furans as HIV-1 entry inhibitors

21 January 2018

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Design, synthesis and biological evaluation of 3-substituted 2,5-dimethyl-N-(3-(1H-tetrazol-5-yl)phenyl)pyrroles as novel potential HIV-1 gp41 inhibitors.

21 January 2018

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Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.

21 January 2018

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Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety.

21 January 2018

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Novel rhodanine derivatives induce growth inhibition followed by apoptosis

21 January 2018

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Design, synthesis and evaluation of novel rhodanine-containing sorafenib analogs as potential antitumor agents

21 January 2018

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Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1.

21 January 2018

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A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors

21 January 2018

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Structure-based virtual screening approach to the discovery of novel inhibitors of eyes absent 2 phosphatase with various metal chelating moieties.

21 January 2018

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 January 2018

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New cholesterol esterase inhibitors based on rhodanine and thiazolidinedione scaffolds.

21 January 2018

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In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors

21 January 2018

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On the mechanism of CFTR inhibition by a thiazolidinone derivative

21 January 2018

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Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening

21 January 2018

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False positives in the early stages of drug discovery

21 January 2018

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Comprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-Lactamase

21 January 2018

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A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

21 January 2018

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A specific mechanism of nonspecific inhibition

21 January 2018

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SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase

21 January 2018

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Chemical probes of UDP-galactopyranose mutase

21 January 2018

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ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens

21 January 2018

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Toxicological evaluation of thiol-reactive compounds identified using a la assay to detect reactive molecules by nuclear magnetic resonance

21 January 2018

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Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-α

21 January 2018

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Efficient synthetic inhibitors of anthrax lethal factor

21 January 2018

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Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp

21 January 2018

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A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo

21 January 2018

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Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region

21 January 2018

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Structure-activity relationships of phenyl-furanyl-rhodanines as inhibitors of RNA polymerase with antibacterial activity on biofilms.

21 January 2018

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Interaction geometries and energies of hydrogen bonds to C[double bond]O and C[double bond]S acceptors: a comparative study.

21 January 2018

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In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. I. Role of cytochrome P450, methyltransferases,

21 January 2018

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Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols

21 January 2018

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Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity.

21 January 2018

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Sulfenic acids as reactive intermediates in xenobiotic metabolism

21 January 2018

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Rhodanine derivatives as inhibitors of JSP-1.

21 January 2018

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Identification of selective inhibitors for the glycosyltransferase MurG via high-throughput screening

21 January 2018

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Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

21 January 2018

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5-Benzylidenethiazolidin-4-ones as Multitarget Inhibitors of Bacterial Mur Ligases

21 January 2018

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Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization

21 January 2018

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