(Q34276848)

1 August 2017

title

Harmine is a potent antimalarial targeting Hsp90 and synergizes with chloroquine and artemisinin (English)

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1 August 2017

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Dea Shahinas

1

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1 August 2017

Gregory Macmullin

2

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1 August 2017

Christan Benedict

3

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1 August 2017

Ian Crandall

4

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1 August 2017

Dylan R Pillai

5

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1 August 2017

language of work or name

English

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publication date

21 May 2012

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Antimicrobial Agents and Chemotherapy

1 August 2017

published in

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1 August 2017

volume

56

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1 August 2017

issue

8

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1 August 2017

page(s)

4207-4213

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Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis)

1 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Conformational dynamics of the molecular chaperone Hsp90

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Harman induces CYP1A1 enzyme through an aryl hydrocarbon receptor mechanism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Structure of the ATP-binding domain of Plasmodium falciparum Hsp90

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Cysteamine, the molecule used to treat cystinosis, potentiates the antimalarial efficacy of artemisinin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Malaria heat shock proteins: drug targets that chaperone other drug targets

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Non-competitive androgen receptor inhibition in vitro and in vivo.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Systems analysis of chaperone networks in the malarial parasite Plasmodium falciparum

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Genetic architecture of Hsp90-dependent drug resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Antimalarial drug synergism and antagonism: mechanistic and clinical significance.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Coot: model-building tools for molecular graphics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Recurrent fever promotes Plasmodium falciparum development in human erythrocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Exposure to beta-carbolines norharman and harman

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Antagonists of Nucleic Acid Derivatives Viii. Synergism in Combinations of Biochemically Related Antimetabolites

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Antimalarial activity of extracts and alkaloids isolated from six plants used in traditional medicine in Mali and Sao Tome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Synergistic in vitro antimalarial activity of plant extracts used as traditional herbal remedies in Mali

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Antimalarial activity of four plants used in traditional medicine in Mali

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

GHKL, an emergent ATPase/kinase superfamily

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Genotoxic effects of structurally related beta-carboline alkaloids.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

In vitro antimalarial activity of vegetal extracts used in West African traditional medicine.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Effects of beta- and gamma-carboline derivatives of DNA topoisomerase activities

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Design, synthesis, and application of novel triclosan prodrugs as potential antimalarial and antibacterial agents

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis J.F. Gmel (Combretaceae).

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421604

Conservation of Hsp90 macromolecular complexes in Saccharomyces cerevisiae

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22615284

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.00328-12

1 reference

release_acg4rvw7prgstmdh7vewhnftqu

1 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/acg4rvw7prgstmdh7vewhnftqu

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

3421604

1 reference

1 August 2017

1 reference