(Q34288655)

1 August 2017

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title

IL-6-like cytokines and cancer cachexia: consequences of chronic inflammation (English)

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1 August 2017

Barton BE

1

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1 August 2017

1 January 2001

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1 August 2017

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1 August 2017

23

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1 August 2017

41-58

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1 August 2017

1

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https://scigraph.springernature.com/pub.10.1385/ir:23:1:41

1 August 2017

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cites work

IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice

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12 December 2020

Cytokine inhibition by a novel steroid, mometasone furoate

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Early onset of reproductive function in normal female mice treated with leptin

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IMPAIRED STAT3 ACTIVATION FOLLOWING LOCALIZED INFLAMMATORY STIMULUS IN IL-6-DEFICIENT MICE

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Interleukin-6-induced protection in hyperoxic acute lung injury.

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Interleukin-1 and interleukin-6 act synergistically to stimulate the release of adrenocorticotropic hormone in vivo

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Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice

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Biomedicine. Protein loss in cancer cachexia

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Nuclear signaling by interleukin-6.

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Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma

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12 December 2020

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells.

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12 December 2020

Multiple forms of human interleukin-6. Phosphoglycoproteins secreted by many different tissues

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12 December 2020

Leptin-specific patterns of gene expression in white adipose tissue

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12 December 2020

Interleukins 6 and 11 protect mice from mortality in a staphylococcal enterotoxin-induced toxic shock model

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12 December 2020

Distinct sets of acute phase plasma proteins are stimulated by separate human hepatocyte-stimulating factors and monokines in rat hepatoma cells

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12 December 2020

Appearance of hybridoma growth factor/interleukin-6 in the serum of mice bearing a methylcholanthrene-induced sarcoma

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12 December 2020

Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice

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12 December 2020

Lipoprotein lipase expression exclusively in liver. A mouse model for metabolism in the neonatal period and during cachexia

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12 December 2020

Regulation of the hepatic synthesis of C1 inhibitor by the hepatocyte stimulating factors interleukin 6 and interferon gamma

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12 December 2020

Molecular cloning and expression of hybridoma growth factor in Escherichia coli.

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12 December 2020

Disseminated growth of a human multiple myeloma cell line in mice with severe combined immunodeficiency disease.

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12 December 2020

Interleukin-6 and ACTH act synergistically to stimulate the release of corticosterone from adrenal gland cells.

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12 December 2020

Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway

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12 December 2020

Tumor necrosis factor and the acute metabolic response to tissue injury in man

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12 December 2020

Neuropeptide Y blocks and reverses interleukin-1 beta-induced anorexia in rats

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12 December 2020

The arcuate nucleus as a primary site of satiety effect of leptin in rats

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12 December 2020

Experimental cancer cachexia: the role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 Bl background and eicosanoid-dependent cachexia

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12 December 2020

Weight-reducing effects of the plasma protein encoded by the obese gene

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12 December 2020

Targeting of leptin to the regulated secretory pathway in pituitary AtT-20 cells

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12 December 2020

Interleukin-6-deficient mice refractory to IgA dysregulation but not anorexia induction by vomitoxin (deoxynivalenol) ingestion

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12 December 2020

Elevated levels of interleukin-6 in cerebrospinal fluid from patients with systemic lupus erythematosus and central nervous system involvement

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12 December 2020

Dexamethasone increases leptin expression in humans in vivo

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12 December 2020

Interleukin 6 inhibits delayed-type hypersensitivity and the development of adjuvant arthritis

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12 December 2020

STAT3 is required for the gp130-mediated full activation of the c-myc gene

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12 December 2020

Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130.

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12 December 2020

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

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12 December 2020

The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor

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12 December 2020

Constitutive production of interleukin-6 and immunologic features in cardiac myxomas

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12 December 2020

Tumors secreting human TNF/cachectin induce cachexia in mice

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12 December 2020

Defective STAT signaling by the leptin receptor in diabetic mice

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12 December 2020

Interleukin-6. The major regulator of acute-phase protein synthesis in man and rat.

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12 December 2020

An in vivo model of human multiple myeloma bone disease

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12 December 2020

Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction

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12 December 2020

Interleukin-6 inhibits the proliferation of B-chronic lymphocytic leukemia cells that is induced by tumor necrosis factor-alpha or -beta

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12 December 2020

Leukaemia inhibitory factor and interleukin 6 are expressed at very low levels in the normal adult mouse and are induced by inflammation

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12 December 2020

Leptin impairs metabolic actions of insulin in isolated rat adipocytes.

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12 December 2020

Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function

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12 December 2020

Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages

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12 December 2020

Interleukin 6, but not ciliary neurotrophic factor or leukaemia inhibitory factor, is responsible for the acute phase response to turpentine-induced myositis.

1 reference

12 December 2020

Involvement of gp130/interleukin-6 receptor transducing component in interleukin-11 receptor

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12 December 2020

Leptin selectively decreases visceral adiposity and enhances insulin action.

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12 December 2020

The common mediator of shock, cachexia, and tumor necrosis.

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12 December 2020

Cachectic effect of ciliary neurotrophic factor on innervated skeletal muscle.

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12 December 2020

Involvement of human interleukin 6 in experimental cachexia induced by a human uterine cervical carcinoma xenograft

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12 December 2020

Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6

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12 December 2020

Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome

1 reference

12 December 2020

Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1 beta and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6

1 reference

12 December 2020

Muscle undergoes atrophy in association with increase of lysosomal cathepsin activity in interleukin-6 transgenic mouse

1 reference

12 December 2020

Differentiation factor/leukemia inhibitory factor protection against lethal endotoxemia in mice: synergistic effect with interleukin 1 and tumor necrosis factor

1 reference

12 December 2020

Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130

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12 December 2020

Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11.

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12 December 2020

Anticachectin/tumor necrosis factor-alpha antibodies attenuate development of cachexia in tumor models

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12 December 2020

Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model.

1 reference

12 December 2020

IL-6 knock-out mice exhibit resistance to splanchnic artery occlusion shock.

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12 December 2020

Characterization and localization of leptin receptors in the rat kidney.

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12 December 2020

Tumor necrosis, cachexia, shock, and inflammation: a common mediator

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12 December 2020

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

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12 December 2020

Macrophage-derived tumor necrosis factor and tumor-derived of leukemia inhibitory factor and interleukin-6: possible cellular mechanisms of cancer cachexia

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12 December 2020

IFN-alpha induces autocrine production of IL-6 in myeloma cell lines

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12 December 2020

Interleukin-6 production in a murine model of Pneumocystis carinii pneumonia: relation to resistance and inflammatory response

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12 December 2020

Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia

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12 December 2020

Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia

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12 December 2020

Is TNF really involved in cachexia?

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12 December 2020

Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation

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12 December 2020

Tumor-derived products induce Il-1 a, Il-1 b, Tnf a, and Il-6 gene expression in murine macrophages: distinctions between tumor- and bacterial endotoxin-induced gene expression

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12 December 2020

Leptin actions on food intake and body temperature are mediated by IL-1

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12 December 2020

Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family

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12 December 2020

Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells

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12 December 2020

Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production

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12 December 2020

Defective inflammatory response in interleukin 6-deficient mice

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12 December 2020

Long-term engraftment of fresh human myeloma cells in SCID mice

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12 December 2020

Chinese hamster ovarian cells transfected with the murine interleukin-6 gene cause hypercalcemia as well as cachexia, leukocytosis and thrombocytosis in tumor-bearing nude mice

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12 December 2020

Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma

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12 December 2020

Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice

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12 December 2020

Interleukin-6 is a prognostic factor in multiple myeloma

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12 December 2020

Uncomplicated starvation versus cancer cachexia

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12 December 2020

In vivo induction of IL-6 by administration of exogenous cytokines and detection of de novo serum levels of IL-6 in tumor-bearing mice

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12 December 2020

Mechanisms of experimental cancer cachexia. Local involvement of IL-1 in colon-26 tumor.

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12 December 2020

Tissue lipoprotein lipase activity and its action in lipoprotein metabolism

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12 December 2020

Interleukin-6 gene expression in multiple myeloma: a characteristic of immature tumor cells

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12 December 2020

Recombinant leptin exchanges between parabiosed mice but does not reach equilibrium

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12 December 2020

Regulation of IL-6 expression by oncostatin M

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12 December 2020

Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats

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12 December 2020

Loss of body fat in lean parabiotic partners of ob/ob mice

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12 December 2020

Cytokine levels (IL-6 and IFN-gamma), acute phase response and nutritional status as prognostic factors in lung cancer

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12 December 2020

A role for leptin and its cognate receptor in hematopoiesis

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12 December 2020

Constitutive expression of IL-6-LIKE cytokines in normal bone marrow: implications for pathophysiology of myeloma

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12 December 2020

Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients

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12 December 2020

Cancer cachexia syndrome developed in nude mice bearing melanoma cells producing leukemia-inhibitory factor

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12 December 2020

Corticotropin-releasing activity of monokines

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12 December 2020

Sequence and structural organization of the human gene encoding ciliary neurotrophic factor

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12 December 2020

Interleukin-6 (IL-6) and acute phase proteins in the disease course of patients with systemic lupus erythematosus

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12 December 2020

Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response

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12 December 2020

Interleukin-6 prevents dexamethasone-induced myeloma cell death.

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12 December 2020

IgG1 plasmacytosis in interleukin 6 transgenic mice

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12 December 2020

Long-term consequences of interleukin-6 overexpression in transgenic mice

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12 December 2020

Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects

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12 December 2020

The effect of interleukin-1, interleukin-6 and its interrelationship on the synthesis of serum amyloid A and C-reactive protein in primary cultures of adult human hepatocytes

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12 December 2020

AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6

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12 December 2020

Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias

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12 December 2020

Suramin inhibits the stimulation of acute phase plasma protein genes by IL-6-type cytokines in rat hepatoma cells

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12 December 2020

Leptin (OB protein), neuropeptide Y, and interleukin-1 interactions as interface mechanisms for the regulation of feeding in health and disease

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12 December 2020

Interleukin 6 is essential for in vivo development of B lineage neoplasms

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12 December 2020

Interleukin 6, the third mediator of acute-phase reaction, modulates hepatic protein synthesis in human and mouse. Comparison with interleukin 1 beta and tumor necrosis factor-alpha

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12 December 2020

Interleukin-HP1-related hybridoma and plasmacytoma growth factors induced by lipopolysaccharide in vivo

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12 December 2020

The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line

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12 December 2020

Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells

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12 December 2020

Indication for linkage of the human OB gene region with extreme obesity

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12 December 2020

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor

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12 December 2020

Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development

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12 December 2020

Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease

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12 December 2020

Interleukin-6 is the central tumor growth factor in vitro and in vivo in multiple myeloma

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12 December 2020

Interleukin-6 immunoreactivity in human tumors

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12 December 2020

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

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12 December 2020

Decreased food intake does not completely account for adiposity reduction after ob protein infusion

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12 December 2020

Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes

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12 December 2020

Production of hybridoma growth factor by human monocytes.

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12 December 2020

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6

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12 December 2020

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors

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12 December 2020

IL-6 receptor and mechanism of signal transduction

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12 December 2020

A model that reproduces syndromes associated with human multiple myeloma in nonirradiated SCID mice

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12 December 2020

Interleukin 6 (IL-6) and its receptor: their role in plasma cell neoplasias

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12 December 2020

Involvement of Interleukin-6 in the Autocrine Stimulation of Chronic Lymphocytic Leukemia B Cells by Tumor Necrosis Factor.

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12 December 2020

Oncostatin M stimulates proliferation in B9 hybridoma cells: potential role of oncostatin M in plasmacytoma development

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12 December 2020

Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: analysis of IL-6 production and IL-6R expression

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12 December 2020

Cloning and expression of human ciliary neurotrophic factor

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12 December 2020

IL-6 gene polymorphism in rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, and in healthy Danes.

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12 December 2020

Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans

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12 December 2020

Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells.

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12 December 2020

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters

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12 December 2020

Efficient immunity against Leishmania major in the absence of interleukin-6.

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12 December 2020

Leukemia inhibitory factor induces changes in lipid metabolism in cultured adipocytes

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12 December 2020

The gp 130 family cytokines IL-6, LIF and OSM but not IL-11 can reverse the anti-proliferative effect of dexamethasone on human myeloma cells

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12 December 2020

Acute release of cytokines is proportional to tissue injury induced by surgical trauma and shock in rats

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12 December 2020

Dexamethasone stimulates leptin release from human adipocytes: unexpected inhibition by insulin

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12 December 2020

Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130

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12 December 2020

Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor

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12 December 2020

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

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12 December 2020

Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells

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12 December 2020

Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon gamma

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12 December 2020

IL-6 expression in neurons of transgenic mice causes reactive astrocytosis and increase in ramified microglial cells but no neuronal damage.

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12 December 2020

Action of recombinant human interleukin 6, interleukin 1 beta and tumor necrosis factor alpha on the mRNA induction of acute-phase proteins

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12 December 2020

The cachexia associated with Trypanosoma cruzi acute infection in mice is attenuated by anti-TNF-alpha, but not by anti-IL-6 or anti-IFN-gamma antibodies.

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12 December 2020

In vivo effects of cardiotrophin-1

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12 December 2020

Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice

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12 December 2020

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

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12 December 2020

Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis.

1 reference

12 December 2020

Regulation of tissue inhibitor of metalloproteinase-1 in fibroblasts and acute phase proteins in hepatocytes in vitro by mouse oncostatin M, cardiotrophin-1, and IL-6.

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12 December 2020

Oncostatin M stimulates excessive extracellular matrix accumulation in a transgenic mouse model of connective tissue disease

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12 December 2020

Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice

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12 December 2020

Interleukin-6 overexpression cannot generate serious disorders in severe combined immunodeficiency mice

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12 December 2020

Interleukin-6: a regulator of plasma protein gene expression in hepatic and non-hepatic tissues

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12 December 2020

Interleukin-6 antagonizes tumor necrosis factor-mediated mycobacteriostatic and mycobactericidal activities in macrophages

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12 December 2020

Cachexia and the acute-phase protein response in inflammation are regulated by interleukin-6

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12 December 2020

Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice

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12 December 2020

Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus

1 reference

12 December 2020

Plasma clearance, organ distribution and target cells of interleukin-6/hepatocyte-stimulating factor in the rat

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12 December 2020

Interleukin 1 alpha increases serum leptin concentrations in humans

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12 December 2020

Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta

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12 December 2020

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

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12 December 2020

Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction.

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12 December 2020

Acute stimulation of glucose metabolism in mice by leptin treatment

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12 December 2020

Effects of interleukin-6 and leukemia inhibitory factor on the acute phase response and DNA synthesis in cultured rat hepatocytes

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12 December 2020

Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo

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12 December 2020

Evidence for the involvement of interleukin 6 in experimental cancer cachexia

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12 December 2020

Mechanisms of host wasting induced by administration of cytokines in rats.

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12 December 2020

The stomach is a source of leptin

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12 December 2020

Activation of IL-6 production by UV irradiation of blood mononuclear cells from patients with systemic lupus erythematosus

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12 December 2020

Liver nonparenchymal cells are stimulated to provide interleukin 6 for induction of the hepatic acute-phase response in endotoxemia but not in remote localized inflammation

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12 December 2020

The biological effects of interleukin 6.

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12 December 2020

IL-6: insights into novel biological activities

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12 December 2020

Protective effect of anti-interleukin (IL)-6 antibody against endotoxin, associated with paradoxically increased IL-6 levels

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12 December 2020

Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice

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12 December 2020

Induction of acute pancreatitis by cerulein in human IL-6 gene transgenic mice

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12 December 2020

Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.

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12 December 2020

Induction of Plasma-Cell Neoplasms in Strain BALB/c Mice with Mineral Oil and Mineral Oil Adjuvants

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12 December 2020

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

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12 December 2020

Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes

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12 December 2020

Interleukin-11 inhibits macrophage interleukin-12 production

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12 December 2020

Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis

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12 December 2020

Physiological effects of CNTF-induced wasting

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12 December 2020

Hepatocyte-stimulating factor III shares structural and functional identity with leukemia-inhibitory factor

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12 December 2020

Hybridoma growth factor

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12 December 2020

Multiple forms of IFN-beta 2/IL-6 in serum and body fluids during acute bacterial infection.

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12 December 2020

Tumor growth and food intake in interleukin-6 gene knock-out mice

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12 December 2020

Normal mitogen-induced suppression of the interleukin-6 (IL-6) response and its deficiency in systemic lupus erythematosus

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12 December 2020

Plasma concentration of total leptin and human lung-cancer-associated cachexia

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12 December 2020

Altered physiology of Purkinje neurons in cerebellar slices from transgenic mice with chronic central nervous system expression of interleukin-6.

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12 December 2020

A nuclear factor for the IL-6 gene (NF-IL6).

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12 December 2020

The expression of leptin and its receptors in pre-ovulatory human follicles.

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12 December 2020

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

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12 December 2020

IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo

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12 December 2020

Identifiers

DOI

10.1385/IR:23:1:41

1 reference

PubMed ID

11417859

Dimensions Publication ID

1 August 2017

0 references

1 reference

PubMed ID

11417859