(Q34300737)

1 August 2017

title

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo (English)

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1 August 2017

author name string

Elizabeth A Harrington

1

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1 August 2017

David Bebbington

2

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1 August 2017

Jeff Moore

3

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1 August 2017

Richele K Rasmussen

4

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1 August 2017

Abi O Ajose-Adeogun

5

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1 August 2017

Tomoko Nakayama

6

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1 August 2017

Joanne A Graham

7

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1 August 2017

Cecile Demur

8

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1 August 2017

Thierry Hercend

9

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1 August 2017

Anita Diu-Hercend

10

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1 August 2017

Michael Su

11

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1 August 2017

Julian M C Golec

12

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1 August 2017

Karen M Miller

13

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1 August 2017

language of work or name

English

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publication date

22 February 2004

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1 August 2017

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1 August 2017

volume

10

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1 August 2017

issue

3

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1 August 2017

page(s)

262-267

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The cellular geography of aurora kinases

1 August 2017

cites work

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The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

21 January 2018

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Mitotic kinases as regulators of cell division and its checkpoints

21 January 2018

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Chromosomal passengers and the (aurora) ABCs of mitosis

21 January 2018

1 reference

On the role of aurora-A in centrosome function

21 January 2018

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Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells

21 January 2018

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Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

21 January 2018

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AIM-1: a mammalian midbody-associated protein required for cytokinesis

21 January 2018

1 reference

Downregulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic cells

21 January 2018

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The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis

21 January 2018

1 reference

Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

21 January 2018

1 reference

Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3

21 January 2018

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

21 January 2018

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Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes

21 January 2018

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Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases

21 January 2018

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CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis

21 January 2018

1 reference

Myosin II regulatory light chain as a novel substrate for AIM-1, an aurora/Ipl1p-related kinase from rat

21 January 2018

1 reference

Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle

21 January 2018

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Human TPX2 is required for targeting Aurora-A kinase to the spindle

21 January 2018

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Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity

21 January 2018

1 reference

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis

21 January 2018

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Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model

21 January 2018

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Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate

21 January 2018

1 reference

Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process

21 January 2018

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MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase

21 January 2018

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Phosphorylation by Aurora B Converts MgcRacGAP to a RhoGAP during Cytokinesis

21 January 2018

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Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase

21 January 2018

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The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast

21 January 2018

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Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.

21 January 2018

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Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers

21 January 2018

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Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

21 January 2018

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Centrosomal kinases, HsAIRK1 and HsAIRK3, are overexpressed in primary colorectal cancers.

21 January 2018

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Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

21 January 2018

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Crystal structure of aurora-2, an oncogenic serine/threonine kinase

21 January 2018

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Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia

21 January 2018

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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

21 January 2018

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A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase

21 January 2018

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Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis.

21 January 2018

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The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Mitotic kinase expression and colorectal cancer progression

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NM1003

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1 August 2017

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