(Q34302499)

1 August 2017

title

Exploiting microRNA regulation for genetic engineering (English)

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1 August 2017

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B Gentner

1

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1 August 2017

L Naldini

series ordinal

2

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1 August 2017

publication date

1 November 2012

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1 August 2017

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1 August 2017

volume

80

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1 August 2017

issue

5

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1 August 2017

page(s)

393-403

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Identification of novel genes coding for small expressed RNAs

1 August 2017

cites work

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An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans

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An extensive class of small RNAs in Caenorhabditis elegans

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Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

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The centrality of RNA.

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Most mammalian mRNAs are conserved targets of microRNAs

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MicroRNAs: small RNAs with a big role in gene regulation

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A mammalian microRNA expression atlas based on small RNA library sequencing

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Evolution of microRNA diversity and regulation in animals

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Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants

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MicroRNAs: target recognition and regulatory functions

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Expanding the microRNA targeting code: functional sites with centered pairing

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Mammalian microRNAs predominantly act to decrease target mRNA levels

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Gene silencing by microRNAs: contributions of translational repression and mRNA decay

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Target RNA-directed trimming and tailing of small silencing RNAs

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Mechanisms and consequences of alternative polyadenylation

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Emerging roles for natural microRNA sponges

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MicroRNAs and their roles in mammalian stem cells

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MicroRNAs accurately identify cancer tissue origin

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MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia

21 January 2018

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Selective blockade of microRNA processing by Lin28

21 January 2018

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miR-181a is an intrinsic modulator of T cell sensitivity and selection

21 January 2018

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MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb

21 January 2018

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Analysis of microRNA knockouts in mice

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microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus

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miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice

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MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity

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Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis.

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miR-34 miRNAs provide a barrier for somatic cell reprogramming

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Hepatic miR-29ab1 expression modulates chronic hepatic injury

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A resource of vectors and ES cells for targeted deletion of microRNAs in mice.

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Chemical modification and design of anti-miRNA oligonucleotides.

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MicroRNA sponges: progress and possibilities

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MicroRNA therapeutics.

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Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy

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Stable knockdown of microRNA in vivo by lentiviral vectors

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Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

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MicroRNA-133 controls cardiac hypertrophy

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Long-term, efficient inhibition of microRNA function in mice using rAAV vectors

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Regulated and multiple miRNA and siRNA delivery into primary cells by a lentiviral platform

21 January 2018

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A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells

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The impact of microRNAs on protein output

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Identification of RNA-protein interaction networks using PAR-CLIP

21 January 2018

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HITS-CLIP: panoramic views of protein-RNA regulation in living cells

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Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer

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Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state

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A microRNA in a multiple-turnover RNAi enzyme complex

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MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells

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Lentivirus-mediated antagomir expression for specific inhibition of miRNA function

21 January 2018

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Kinetic analysis reveals the fate of a microRNA following target regulation in mammalian cells

21 January 2018

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Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy

21 January 2018

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A microRNA-based system for selecting and maintaining the pluripotent state in human induced pluripotent stem cells

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Live Cell Monitoring of hiPSC Generation and Differentiation Using Differential Expression of Endogenous microRNAs

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Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors

21 January 2018

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MicroRNA-124 is a subventricular zone neuronal fate determinant.

21 January 2018

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A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice

21 January 2018

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In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance

21 January 2018

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A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia A.

21 January 2018

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miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy

21 January 2018

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Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells

21 January 2018

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Double-detargeted oncolytic adenovirus shows replication arrest in liver cells and retains neuroendocrine cell killing ability

21 January 2018

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Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA.

21 January 2018

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Construction of an oncolytic herpes simplex virus that precisely targets hepatocellular carcinoma cells

21 January 2018

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MicroRNA controlled adenovirus mediates anti-cancer efficacy without affecting endogenous microRNA activity

21 January 2018

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Engineering microRNA responsiveness to decrease virus pathogenicity

21 January 2018

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Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene

21 January 2018

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Attenuation of vesicular stomatitis virus encephalitis through microRNA targeting

21 January 2018

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Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines

21 January 2018

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Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype

21 January 2018

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Neurovirulent flavivirus can be attenuated in mice by incorporation of neuron-specific microRNA recognition elements into viral genome

21 January 2018

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Use of microRNA Let-7 to control the replication specificity of oncolytic adenovirus in hepatocellular carcinoma cells

21 January 2018

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MicroRNA regulation of oncolytic herpes simplex virus-1 for selective killing of prostate cancer cells

21 January 2018

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MicroRNA regulation of glycoprotein B5R in oncolytic vaccinia virus reduces viral pathogenicity without impairing its antitumor efficacy

21 January 2018

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microRNA122-regulated transgene expression increases specificity of cardiac gene transfer upon intravenous delivery of AAV9 vectors

21 January 2018

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MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression

21 January 2018

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MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression

21 January 2018

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Sequence requirements for micro RNA processing and function in human cells

21 January 2018

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Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters.

21 January 2018

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MicroRNAs can generate thresholds in target gene expression

21 January 2018

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High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries

21 January 2018

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Regulation of the germinal center response by microRNA-155

21 January 2018

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Development of a dual-luciferase reporter system for in vivo visualization of MicroRNA biogenesis and posttranscriptional regulation

21 January 2018

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Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice

21 January 2018

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Manipulating Immune Tolerance with Micro-RNA Regulated Gene Therapy.

21 January 2018

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Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

21 January 2018

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miRNA-mediated silencing in hepatocytes can increase adaptive immune responses to adenovirus vector-delivered transgenic antigens

21 January 2018

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Engineered lentiviral vector targeting astrocytes in vivo

21 January 2018

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Gene therapy for immunodeficiency due to adenosine deaminase deficiency.

21 January 2018

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Safety of arylsulfatase A overexpression for gene therapy of metachromatic leukodystrophy.

21 January 2018

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Gene therapy of chronic granulomatous disease: the engraftment dilemma

21 January 2018

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MicroRNA-150-regulated vectors allow lymphocyte-sparing transgene expression in hematopoietic gene therapy

21 January 2018

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Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

21 January 2018

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A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships

21 January 2018

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A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication

21 January 2018

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MicroRNA-sensitive oncolytic measles viruses for cancer-specific vector tropism

21 January 2018

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Rationalizing the development of live attenuated virus vaccines

21 January 2018

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MicroRNA-mediated species-specific attenuation of influenza A virus

21 January 2018

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Replication in cells of hematopoietic origin is necessary for Dengue virus dissemination

21 January 2018

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In vitro and in vivo characterization of microRNA-targeted alphavirus replicon and helper RNAs

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/TAN.12002

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1 August 2017

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