(Q34309971)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

Benzodiazepine dependence and its treatment with low dose flumazenil (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

ChEBI release 2020-05-28

ChEBI ID

5103

benzodiazepine dependence

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Amanda Norman

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Dana Hince

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

author name string

Jan Krzysztof Melichar

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Gary Kenneth Hulse

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

language of work or name

English

0 references

publication date

1 February 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json

British Journal of Clinical Pharmacology

17 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

volume

77

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

page(s)

285-294

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json

Withdrawal and psychological sequelae, and patient satisfaction associated with subcutaneous flumazenil infusion for the management of benzodiazepine withdrawal: a case series.

17 February 2020

cites work

1 reference

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Mechanisms Underlying Tolerance after Long-Term Benzodiazepine Use: A Future for Subtype-Selective GABA(A) Receptor Modulators?

6 July 2018

1 reference

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High dose benzodiazepine dependence: description of 29 patients treated with flumazenil infusion and stabilised with clonazepam

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

A pilot study of the effects of flumazenil on symptoms persisting after benzodiazepine withdrawal

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Guide to Receptors and Channels (GRAC), 5th edition

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Benzodiazepines revisited—will we ever learn?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Regulation of GABA(A) receptor subunit expression by pharmacological agents.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

The complexity of the GABAA receptor shapes unique pharmacological profiles.

6 July 2018

1 reference

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The role of flumazenil in the treatment of benzodiazepine dependence: physiological and psychological profiles.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Withdrawing Benzodiazepines in Primary Care

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Addiction: the clinical interface

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Open-label study of a proprietary treatment program targeting type A gamma-aminobutyric acid receptor dysregulation in methamphetamine dependence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Pharmacological interventions for benzodiazepine mono-dependence management in outpatient settings

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

The diagnosis and management of benzodiazepine dependence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Use of Flumazenil in benzodiazepine overdose

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Acute tryptophan depletion. Part I: rationale and methodology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

GABAA receptor subtypes: any clues to the mechanism of benzodiazepine dependence?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Intravenous flumazenil versus oxazepam tapering in the treatment of benzodiazepine withdrawal: a randomized, placebo‐controlled study

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Predictors of relapse after discontinuation of long-term benzodiazepine use by minimal intervention: a 2-year follow-up study

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Neuroadaptive processes in GABAergic and glutamatergic systems in benzodiazepine dependence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

The experimental pharmacotherapy of benzodiazepine withdrawal

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Basic pharmacologic mechanisms involved in benzodiazepine tolerance and withdrawal

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Flumazenil challenge in social phobia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Benzodiazepine dependence and withdrawal: a review of the syndrome and its clinical management

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Effects of flumazenil in the treatment of benzodiazepine withdrawal--a double-blind pilot study

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

A five minute experience in the elevated plus-maze alters the state of the benzodiazepine receptor in the dorsal raphe nucleus.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Intraseptal flumazenil enhances, while diazepam binding inhibitor impairs, performance in a working memory task

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Allosteric uncoupling after chronic benzodiazepine exposure of recombinant gamma-aminobutyric acid(A) receptors expressed in Sf9 cells: ligand efficacy and subtype selectivity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Effect of calcium channel blockers on withdrawal syndrome of lorazepam in rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Flumazenil: a benzodiazepine antagonist.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Benzodiazepine withdrawal: behavioural pharmacology and neurochemical changes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Increased 5-HT release mediates the anxiogenic response during benzodiazepine withdrawal: a review of supporting neurochemical and behavioural evidence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

The benzodiazepine withdrawal syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Benzodiazepine withdrawal: an unfinished story

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Dependence on benzodiazepines.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Withdrawal from long-term benzodiazepine treatment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Length of treatment with anxiolytic sedatives and response to their sudden withdrawal

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Enhancement of learning and memory in mice by a benzodiazepine antagonist

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Long-term Therapeutic Use of Benzodiazepines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Flumazenil provocation of panic attacks. Evidence for altered benzodiazepine receptor sensitivity in panic disorder

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

The prolonged benzodiazepine withdrawal syndrome: anxiety or hysteria?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Protracted withdrawal syndromes from benzodiazepines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Feasibility of reversing benzodiazepine tolerance with flumazenil

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Learning and memory-enhancing effects of Ro 15-4513: A comparison with flumazenil

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Psychopharmacological properties of calcium channel inhibitors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Making sense of GABA(A) receptor subtypes: is a new nomenclature needed?

6 July 2018

1 reference

The Severity of Dependence Scale (SDS) as screening test for benzodiazepine dependence: SDS validation study.

21 January 2018

1 reference

Protracted Withdrawal From Benzodiazepines: The Post-Withdrawal Syndrome

21 January 2018

1 reference

Cognitive-behavioural, pharmacological and psychosocial predictors of outcome during tapered discontinuation of benzodiazepine

21 January 2018

1 reference

In-patient benzodiazepine withdrawal: comparison of fixed and symptom-triggered taper methods

21 January 2018

1 reference

Liquid chromatographic-mass spectrometric method for the determination of fluoxetine and norfluoxetine in human plasma: application to clinical study

21 January 2018

1 reference

Determination of flumazenil in human plasma by liquid chromatography-electrospray ionisation tandem mass spectrometry

21 January 2018

1 reference

Use of flumazenil in the treatment of drug overdose: a double-blind and open clinical study in 110 patients.

21 January 2018

1 reference

Agonist substitution for high‐dose benzodiazepine‐dependent patients: let us not forget the importance of flumazenil

21 January 2018

1 reference

Focal nonconvulsive seizures during detoxification for benzodiazepine abuse.

21 January 2018

1 reference

Does 5-HT restrain panic? A tryptophan depletion study in panic disorder patients recovered on paroxetine

21 January 2018

1 reference

Rapid tryptophan depletion following cognitive behavioural therapy for panic disorder

21 January 2018

1 reference

Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice.

21 January 2018

1 reference

Flumazenil reduces midazolam-induced cognitive impairment without altering pharmacokinetics

21 January 2018

1 reference

The pharmacokinetic-pharmacodynamic (Digit Symbol Substitution Test) relationship of flumazenil in a midazolam steady-state model in healthy volunteers

21 January 2018

1 reference

Microinfusions of flumazenil into the basolateral but not the central nucleus of the amygdala enhance memory consolidation in rats

21 January 2018

1 reference

Flumazenil administration attenuates cognitive impairment in immature rats after controlled cortical impact

21 January 2018

1 reference

Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Long-term therapeutic use of benzodiazepines. I. Effects of abrupt discontinuation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014019

Withdrawal symptoms from high dose benzodiazepines in poly drug users

28 October 2018

1 reference

12 December 2020

(-)Pentobarbital opens ion channels of long duration in cultured mouse spinal neurons

1 reference

12 December 2020

Blood naltrexone and 6-beta-naltrexol levels following naltrexone implant: comparing two naltrexone implants

1 reference

12 December 2020

Withdrawal reactions from chlordiazepoxide ("Librium")

1 reference

12 December 2020

Behavioral, neuroendocrine, and cardiovascular response to flumazenil: no evidence for an altered benzodiazepine receptor sensitivity in panic disorder

1 reference

12 December 2020

Flumazenil in alcohol withdrawal: a double-blind placebo-controlled study

1 reference

12 December 2020

Identifiers

DOI

10.1111/BCP.12023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

PubMed publication ID

23126253

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23126253%20AND%20SRC:MED&resulttype=core&format=json