(Q34321767)

1 August 2017

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title

JAKs and STATs in immunity, immunodeficiency, and cancer (English)

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1 August 2017

John J O'Shea

1

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1 August 2017

Steven M Holland

series ordinal

2

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1 August 2017

Louis M Staudt

series ordinal

3

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1 August 2017

language of work or name

English

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publication date

1 January 2013

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The New England Journal of Medicine

1 August 2017

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1 August 2017

368

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1 August 2017

161-170

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1 August 2017

2

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MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

1 August 2017

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12 December 2020

Granulocyte colony-stimulating factor receptor mutations in severe congenital neutropenia transforming to acute myelogenous leukemia confer resistance to apoptosis and enhance cell survival.

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12 December 2020

Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas

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12 December 2020

MYD88 L265P somatic mutation in Waldenström's macroglobulinemia.

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12 December 2020

A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory

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12 December 2020

Activating L265P mutations of the MYD88 gene are common in primary central nervous system lymphoma.

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12 December 2020

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

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12 December 2020

Higher response to lenalidomide in relapsed/refractory diffuse large B-cell lymphoma in nongerminal center B-cell-like than in germinal center B-cell-like phenotype.

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12 December 2020

The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival

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12 December 2020

Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis

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12 December 2020

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

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12 December 2020

JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis

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12 December 2020

Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

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12 December 2020

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

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12 December 2020

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia

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12 December 2020

Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis

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12 December 2020

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia

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12 December 2020

Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis

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12 December 2020

Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24,577 first-degree relatives of 11,039 patients with myeloproliferative neoplasms in Sweden

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12 December 2020

Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease

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12 December 2020

Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma

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12 December 2020

Identification of somatic JAK1 mutations in patients with acute myeloid leukemia

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12 December 2020

Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity

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12 December 2020

BCR and TLR signaling pathways are recurrently targeted by genetic changes in splenic marginal zone lymphomas

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12 December 2020

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

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12 December 2020

Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

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12 December 2020

Efficacy and safety of tofacitinib, an oral Janus kinase inhibitor, in the treatment of psoriasis: a Phase 2b randomized placebo-controlled dose-ranging study.

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12 December 2020

A novel STAT1 mutation associated with disseminated mycobacterial disease

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12 December 2020

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

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12 December 2020

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis

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12 December 2020

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

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12 December 2020

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus

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12 December 2020

Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia

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12 December 2020

STATs in cancer inflammation and immunity: a leading role for STAT3

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12 December 2020

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

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12 December 2020

Somatic STAT3 mutations in large granular lymphocytic leukemia

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12 December 2020

Inborn errors of human JAKs and STATs

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12 December 2020

Genomics and the multifactorial nature of human autoimmune disease

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12 December 2020

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia.

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12 December 2020

A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms.

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12 December 2020

Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey

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12 December 2020

The JAK-STAT pathway at twenty

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12 December 2020

Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells

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12 December 2020

Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma

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12 December 2020

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

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12 December 2020

Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia.

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12 December 2020

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

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12 December 2020

Growth hormone insensitivity associated with a STAT5b mutation

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12 December 2020

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

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12 December 2020

A patient with tyrosine kinase 2 deficiency without hyper-IgE syndrome

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12 December 2020

Oncogenically active MYD88 mutations in human lymphoma

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12 December 2020

Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation

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12 December 2020

JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis

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12 December 2020

Cooperative epigenetic modulation by cancer amplicon genes

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12 December 2020

Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells

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12 December 2020

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

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12 December 2020

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

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12 December 2020

Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma

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12 December 2020

Janus kinase deregulation in leukemia and lymphoma

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12 December 2020

Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells

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12 December 2020

A partial form of recessive STAT1 deficiency in humans

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12 December 2020

NF-κB and STAT3 - key players in liver inflammation and cancer

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12 December 2020

STAT3 mutations in the hyper-IgE syndrome

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12 December 2020

Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).

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12 December 2020

Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7.

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12 December 2020

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

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12 December 2020

Critical requirement for Stat5 in a mouse model of polycythemia vera

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12 December 2020

STAT proteins: novel molecular targets for cancer drug discovery

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12 December 2020

Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

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12 December 2020

A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study

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12 December 2020

STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis

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12 December 2020

Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency

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12 December 2020

JAK1 mutations are not frequent events in adult T-ALL: a GRAALL study

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12 December 2020

A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms

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12 December 2020

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

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12 December 2020

JAK mutations in high-risk childhood acute lymphoblastic leukemia

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12 December 2020

Hyper-IgE syndrome with recurrent infections--an autosomal dominant multisystem disorder

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12 December 2020

Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

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12 December 2020

Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia

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12 December 2020

Stat proteins and oncogenesis

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12 December 2020

Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice.

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12 December 2020

Jaks and STATs: biological implications

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12 December 2020

JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms

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12 December 2020

Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity

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12 December 2020

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

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12 December 2020

Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells

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12 December 2020

Nonredundant roles for Stat5a/b in directly regulating Foxp3

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12 December 2020

STAT signaling in head and neck cancer

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12 December 2020

STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant

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12 December 2020

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

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12 December 2020

FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma

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12 December 2020

Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes

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12 December 2020

Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias

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12 December 2020

Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia

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12 December 2020

Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis.

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12 December 2020

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

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12 December 2020

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

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12 December 2020

A chemical biology approach to developing STAT inhibitors: molecular strategies for accelerating clinical translation

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12 December 2020

A gain-of-function mutation of JAK2 in myeloproliferative disorders

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12 December 2020

Identifiers

DOI

10.1056/NEJMRA1202117

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release_wg2gg2u4dne3ph4v2v7kiwyr6y

1 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/wg2gg2u4dne3ph4v2v7kiwyr6y

24 November 2022

mapped directly with Wikidata item

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