(Q34322677)

1 August 2017

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title

Escitalopram versus citalopram: the surprising role of the R-enantiomer (English)

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1 August 2017

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Connie Sánchez

1

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1 August 2017

Klaus P Bøgesø

2

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1 August 2017

Bjarke Ebert

3

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1 August 2017

Elin Heldbo Reines

4

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1 August 2017

Claus Braestrup

5

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1 August 2017

publication date

1 July 2004

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1 August 2017

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1 August 2017

volume

174

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1 August 2017

issue

2

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1 August 2017

page(s)

163-176

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Interactions of histaminergic and serotonergic neurons in the hypothalamic regulation of prolactin and ACTH secretion

1 August 2017

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Resolution, absolute stereochemistry, and pharmacology of the S-(+)- and R-(-)-isomers of the apparent partial AMPA receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid [(R,S)-APPA].

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Role of the serotonergic system in the forced swimming test

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Chirality and drugs used in psychiatry: nice to know or need to know?

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12 December 2020

Serum corticosterone increases reflect enhanced uptake inhibitor-induced elevation of extracellular 5-hydroxytryptamine in rat hypothalamus

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12 December 2020

2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity

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12 December 2020

High-affinity binding of [125I]RTI-55 to dopamine and serotonin transporters in rat brain

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12 December 2020

Steady-state pharmacokinetics of the enantiomers of citalopram and its metabolites in humans

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12 December 2020

In vitro metabolism of mirtazapine enantiomers by human cytochrome P450 enzymes

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12 December 2020

Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative

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12 December 2020

Stereoselective interaction of mianserin with 5-HT3 receptors

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12 December 2020

LY248686, a new inhibitor of serotonin and norepinephrine uptake

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12 December 2020

Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study

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12 December 2020

Fixed-dose trial of the single isomer SSRI escitalopram in depressed outpatients

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12 December 2020

Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities

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12 December 2020

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12 December 2020

Sensitive procedure for the determination of reboxetine enantiomers in human plasma by reversed-phase high-performance liquid chromatography with fluorimetric detection after chiral derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate

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12 December 2020

Novel phenylpiperidine opioid antagonists and partial agonists: effects on fluid consumption

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12 December 2020

The pharmacological effect of citalopram residues in the (S)-(+)-enantiomer

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12 December 2020

Anxiolytic-Like Effects of Escitalopram, Citalopram, and R-Citalopram in Maternally Separated Mouse Pups

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12 December 2020

Do equivalent doses of escitalopram and citalopram have similar efficacy? A pooled analysis of two positive placebo-controlled studies in major depressive disorder

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12 December 2020

Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain

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12 December 2020

Do animal models of anxiety predict anxiolytic-like effects of antidepressants?

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12 December 2020

Stereoselective HPLC-assay for citalopram and its metabolites

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12 December 2020

Effects of viloxazine, its optical isomers and its major metabolites on biogenic amine uptake mechanisms in vitro and in vivo

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12 December 2020

R-citalopram counteracts the antidepressant-like effect of escitalopram in a rat chronic mild stress model.

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12 December 2020

Comparison of the effects of mianserin and its enantiomers and metabolites on a behavioral screen for antidepressant activity

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12 December 2020

Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins

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12 December 2020

Low-dose citalopram as a 5-HT neuroendocrine probe

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12 December 2020

Anesthetic and convulsant barbiturates alter gamma-aminobutyric acid-stimulated chloride flux across brain membranes

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12 December 2020

Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication

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12 December 2020

Putting chirality to work: the strategy of chiral switches

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12 December 2020

Determination of the enantiomers of mianserin, desmethylmianserin, and 8-hydroxymianserin in the plasma and urine of mianserin-treated patients

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12 December 2020

Selective serotonin reuptake inhibitors and neuroendocrine function

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12 December 2020

Comparison of escitalopram and citalopram efficacy: A meta-analysis

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12 December 2020

Plasma levels of citalopram enantiomers and metabolites in elderly patients

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12 December 2020

Affinity modulation of [3H]imipramine, [3H]paroxetine and [3H]citalopram binding to the 5-HT transporter from brain and platelets

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12 December 2020

The role of the primary care physician in patients' adherence to antidepressant therapy.

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12 December 2020

Separate site(s) of action of optical isomers of 1-methyl-5-phenyl-5-propylbarbituric acid with opposite pharmacological activities at the GABA receptor complex

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12 December 2020

A New Depression Scale Designed to be Sensitive to Change

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12 December 2020

Transport mechanisms for the antidepressant citalopram in brain microvessel endothelium

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12 December 2020

R-citalopram counteracts the effect of escitalopram in a rat conditioned fear stress model of anxiety

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12 December 2020

Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram

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12 December 2020

Stereoselective and species‐dependent kinetics of reboxetine in mouse and rat

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12 December 2020

Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells

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12 December 2020

Serotonin uptake inhibitors differentially modulate high affinity imipramine dissociation in human platelet membranes

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12 December 2020

Escitalopram (S-enantiomer of citalopram): clinical efficacy and onset of action predicted from a rat model

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12 December 2020

Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine

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12 December 2020

Neurochemical effects of the enantiomers of mirtazapine in normal rats

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12 December 2020

Behavioral and radioreceptor analysis of viloxazine stereoisomers

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12 December 2020

Assessing antidepressant activity in rodents: recent developments and future needs

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12 December 2020

Escitalopram in the treatment of panic disorder: a randomized, double-blind, placebo-controlled trial.

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12 December 2020

The mouse light-dark paradigm: a review

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12 December 2020

Pharmacokinetics and biotransformation of mirtazapine in human volunteers

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12 December 2020

Optical isomers of 2-(2-ethoxyphenoxymethyl)tetrahydro-1,4-oxazine (viloxazine) and related compounds

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12 December 2020

The activity of 25 paroxetine/femoxetine structure variants in various reactions, assumed to be important for the effect of antidepressants

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12 December 2020

R-citalopram inhibits functional and 5-HTP-evoked behavioural responses to the SSRI, escitalopram

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12 December 2020

Stress-induced vocalisation in adult animals. A valid model of anxiety?

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12 December 2020

R-citalopram attenuates anxiolytic effects of escitalopram in a rat ultrasonic vocalisation model

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12 December 2020

The R-enantiomer of citalopram counteracts escitalopram-induced increase in extracellular 5-HT in the frontal cortex of freely moving rats

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12 December 2020

Selectivity of (3)H-MADAM binding to 5-hydroxytryptamine transporters in vitro and in vivo in mice; correlation with behavioural effects

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12 December 2020

Quantitative analysis of the interaction between the agonist and antagonist isomers of picenadol (LY150720) on electric shock titration in the squirrel monkey

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12 December 2020

Problems with currently available antidepressants.

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12 December 2020

Which bioequivalence study for a racemic drug? Application to milnacipran

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12 December 2020

Isolation-induced aggression in mice: effects of 5-hydroxytryptamine uptake inhibitors and involvement of postsynaptic 5-HT1A receptors

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12 December 2020

Citalopram therapy for depression: a review of 10 years of European experience and data from U.S. clinical trials.

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12 December 2020

Animal models as simulations of depression

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12 December 2020

Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

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12 December 2020

A rating scale for depression

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12 December 2020

The potential therapeutic role of the enantiomers and metabolites of mianserin

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12 December 2020

Antidepressive drugs can change the affinity of [3H]imipramine and [3H]paroxetine binding to platelet and neuronal membranes.

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12 December 2020

Escitalopram (10-20 mg/day) is effective and well tolerated in a placebo-controlled study in depression in primary care

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12 December 2020

Interaction of the enantiomers of fluoxetine and norfluoxetine with human liver cytochromes P450

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12 December 2020

R-citalopram functionally antagonises escitalopram in vivo and in vitro: evidence for kinetic interaction at the serotonin transporter

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12 December 2020

10.1007/S00213-004-1865-Z

Identifiers

DOI

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Dimensions Publication ID

1 August 2017

1038838405

0 references

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