(Q34328543)

1 August 2017

1 reference

title

Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function (English)

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1 August 2017

Jain RK

1

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PubMed ID

11489479

1 August 2017

language of work or name

English

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publication date

1 July 2001

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Journal of Controlled Release

1 August 2017

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1 August 2017

74

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1 August 2017

1-3

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1 August 2017

7-25

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Barriers to drug delivery in solid tumors

1 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Tissue-isolated human tumor xenografts in athymic nude mice

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Geometric resistance and microvascular network architecture of human colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Microcirculatory flow changes during tissue growth

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Dynamics of neovascularization in normal tissue.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Tumor induction of VEGF promoter activity in stromal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Quantitative angiogenesis assays: progress and problems

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Perfusion of single tumor microvessels: application to vascular permeability measurement

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Effect of local anti-VEGF antibody treatment on tumor microvessel permeability

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Hyperplasia of lymphatic vessels in VEGF-C transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Return of lymphatic function after flap transfer for acute lymphedema

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Erythrocytes enhance lymphocyte rolling and arrest in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Lateral view flow system for studies of cell adhesion and deformation under flow conditions

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Solid stress inhibits the growth of multicellular tumor spheroids

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Pharmacokinetics of methotrexate in solid tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Angiogenesis in cancer and other diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Transmural Coupling of Fluid Flow in Microcirculatory Network and Interstitium in Tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Scale-invariant behavior and vascular network formation in normal and tumor tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Fractal characteristics of tumor vascular architecture during tumor growth and regression

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Cancer, angiogenesis and fractals.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Fluorescence ratio imaging measurement of pH gradients: calibration and application in normal and tumor tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Oxygenation in tumors by modified hemoglobins.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Formation of endothelial cell networks

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Transport of molecules across tumor vasculature

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Microvascular permeability of normal and neoplastic tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Openings between defective endothelial cells explain tumor vessel leakiness

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Leaky vessels? Call Ang1!

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Interstitial fluid pressure in intracranial tumours in patients and in rodents

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Interstitial fluid pressure in breast cancer, benign breast conditions, and breast parenchyma

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Fluid and protein fluxes across small and large pores in the microvasculature. Application of two-pore equations

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Diffusion and partitioning of proteins in charged agarose gels

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Hindered diffusion in agarose gels: test of effective medium model

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Direct in vivo measurement of targeted binding in a human tumor xenograft

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Measurement of mass transport and reaction parameters in bulk solution using photobleaching. Reaction limited binding regime

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

In vitro measurement and screening of monoclonal antibody affinity using fluorescence photobleaching

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Delivery of novel therapeutic agents in tumors: physiological barriers and strategies

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Role of erythrocytes in leukocyte-endothelial interactions: mathematical model and experimental validation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

A method for labeling cells for positron emission tomography (PET) studies

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Kinetics of interleukin-2 induced changes in rigidity of human natural killer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Leukocyte-endothelial adhesion and angiogenesis in tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Reduction of rigidity in human activated natural killer cells by thioglycollate treatment.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Endothelial adhesiveness for blood neutrophils is inhibited by transforming growth factor-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Modulation of the organ microenvironment for treatment of cancer metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Effects of basic fibroblast growth factor on human microvessel endothelial cell migration on collagen I correlates inversely with adhesion and is cell density dependent

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

1 reference

7 January 2021

Physiologically Based Pharmacokinetic Modeling: Principles and Applications

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Role of nitric oxide in angiogenesis and microcirculation in tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

Delivery of molecular medicine to solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

The next frontier of molecular medicine: delivery of therapeutics.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2801%2900306-6

7 January 2021

10.1016/S0168-3659(01)00306-6

Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

11489479