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Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential
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Europe PubMed Central
PMCID
3615879
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23569388%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
title
Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3615879
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23569388%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
main subject
pharmacology
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author
Andrey Sorokin
series ordinal
2
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Europe PubMed Central
PMCID
3615879
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23569388%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
author name string
Anna Alexanian
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3615879
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23569388%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
language of work or name
English
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publication date
26 March 2013
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Europe PubMed Central
PMCID
3615879
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23569388%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
published in
OncoTargets and Therapy
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Europe PubMed Central
PMCID
3615879
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23569388%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
volume
6
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stated in
Europe PubMed Central
PMCID
3615879
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23569388%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
page(s)
243-255
1 reference
stated in
Europe PubMed Central
PMCID
3615879
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23569388%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
copyright license
Creative Commons Attribution-NonCommercial 3.0 Unported
start time
1 March 2013
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April 2022 Public Data File from Crossref
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copyrighted
0 references
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20-HETE-producing enzymes are up-regulated in human cancers.
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20-HETE in neovascularization
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Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow
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Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer
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20-HETE increases NADPH oxidase-derived ROS production and stimulates the L-type Ca2+ channel via a PKC-dependent mechanism in cardiomyocytes
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Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.
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20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism
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Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury
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20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease
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Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo
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A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats.
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20-Hydroxyeicosatetraenoic acid (20-HETE) stimulates migration of vascular smooth muscle cells
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Role of 20-HETE in the pial arteriolar constrictor response to decreased hematocrit after exchange transfusion of cell-free polymeric hemoglobin
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Contribution of CYP4A8 to the formation of 20-hydroxyeicosatetraenoic acid from arachidonic acid in rat kidney
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
Measurement of eicosanoids in cancer tissues
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
Elevated 12- and 20-hydroxyeicosatetraenoic acid in urine of patients with prostatic diseases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
Platelet-type 12-lipoxygenase activates NF-kappaB in prostate cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
Inhibitors of 20-HETE formation promote salt-sensitive hypertension in rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
Gene transfer of thromboxane A(2) synthase and prostaglandin I(2) synthase antithetically altered tumor angiogenesis and tumor growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
PGE(2) stimulates VEGF expression in endothelial cells via ERK2/JNK1 signaling pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
Prostaglandin E2 increases growth and motility of colorectal carcinoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism by cyclooxygenase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615879
retrieved
27 October 2018
Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23569388
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Leukotriene synthesis by human gastrointestinal tissues
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23569388
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Translational studies on Cox-2 inhibitors in the prevention and treatment of colon cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23569388
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
12(S)-HETE promotes tumor-cell adhesion by increasing surface expression of alpha V beta 3 integrins on endothelial cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23569388
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23569388
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.2147/OTT.S31586
1 reference
stated in
Europe PubMed Central
PMCID
3615879
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23569388%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
PMCID
3615879
1 reference
stated in
Europe PubMed Central
PMCID
3615879
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23569388%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
PubMed ID
23569388
1 reference
stated in
Europe PubMed Central
PMCID
3615879
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23569388%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
ResearchGate publication ID
236140808
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