(Q34340531)

1 August 2017

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title

Alpha synuclein aggregation: is it the toxic gain of function responsible for neurodegeneration in Parkinson's disease? (English)

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1 August 2017

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Rajagopalan S

1

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PubMed ID

11511392

1 August 2017

Andersen JK

series ordinal

2

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1 August 2017

1 September 2001

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Mechanisms of Ageing and Development

1 August 2017

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1 August 2017

122

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1 August 2017

14

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1 August 2017

1499-1510

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A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease

1 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

What causes the build-up of ubiquitin-containing inclusions in Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

The possible relation of glutathione, melanin and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) to Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Degradation of alpha-synuclein by proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Synucleins in synaptic plasticity and neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Synthetic filaments assembled from C-terminally truncated alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Neuropathology of synuclein aggregates

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

The genetics of disorders with synuclein pathology and parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

A Drosophila model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Molecular genetic analysis of a novelParkin gene in Japanese families with autosomal recessive juvenile parkinsonism: Evidence for variable homozygous deletions in theParkin gene in affected individuals

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Why are nigral catecholaminergic neurons more vulnerable than other cells in Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Understanding cell death in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Synelfin regulation during the critical period for song learning in normal and isolated juvenile zebra finches.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Late-onset neurodegenerative diseases--the role of protein insolubility

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Association studies of Parkinson's disease and parkin polymorphisms

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

1 reference

7 January 2021

Deletions in the Parkin gene and genetic heterogeneity in a Greek family with early onset Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Parkinson's disease: a disorder due to nigral glutathione deficiency?

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Synucleins are a novel class of substrates for G protein-coupled receptor kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Synphilin-1 is present in Lewy bodies in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Oxidative stress and genetics in the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

10.1016/S0047-6374(01)00283-4

Identifiers

DOI

1 reference

release_xfi3hx2jvbhf7fajet6l4zjf7u

1 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xfi3hx2jvbhf7fajet6l4zjf7u

24 November 2022

mapped directly with Wikidata item

PubMed ID

11511392

1 reference

PubMed ID

11511392