(Q34344683)

1 August 2017

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases (English)

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1 August 2017

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Bai Lu

1

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1 August 2017

Guhan Nagappan

2

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1 August 2017

Xiaoming Guan

3

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1 August 2017

Pradeep J Nathan

4

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1 August 2017

Paul Wren

5

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1 August 2017

language of work or name

English

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publication date

15 May 2013

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Nature Reviews Neuroscience

1 August 2017

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1 August 2017

14

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1 August 2017

6

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1 August 2017

401-416

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https://scigraph.springernature.com/pub.10.1038/nrn3505

1 August 2017

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Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.

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Alzheimer's disease: clinical trials and drug development

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Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific.

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Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept).

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Can Alzheimer disease be prevented by amyloid-beta immunotherapy?

31 March 2020

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Efficacy of memantine in delaying clinical worsening in Alzheimer's disease (AD): responder analyses of nine clinical trials with patients with moderate to severe AD.

31 March 2020

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Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine.

31 March 2020

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Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies

31 March 2020

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Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

31 March 2020

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

31 March 2020

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Alzheimer's disease: synaptic dysfunction and Abeta

31 March 2020

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Alzheimer's disease is a synaptic failure

31 March 2020

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

31 March 2020

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Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.

31 March 2020

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Hippocampal synaptic plasticity in Alzheimer's disease: what have we learned so far from transgenic models?

31 March 2020

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Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice

31 March 2020

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

31 March 2020

1 reference

Spatial relationship between synapse loss and beta-amyloid deposition in Tg2576 mice

31 March 2020

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

31 March 2020

1 reference

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

31 March 2020

1 reference

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease.

31 March 2020

1 reference

Quantitative assessment of cortical synaptic density in Alzheimer's disease.

31 March 2020

1 reference

Quantitative synaptic alterations in the human neocortex during normal aging

31 March 2020

1 reference

Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment.

31 March 2020

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Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment.

31 March 2020

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Characterizing Alzheimer's disease using a hypometabolic convergence index

31 March 2020

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Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

31 March 2020

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Synaptic dysfunction in Parkinson's disease.

31 March 2020

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Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

31 March 2020

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Structural basis of long-term potentiation in single dendritic spines

31 March 2020

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Nanoscale analysis of structural synaptic plasticity

31 March 2020

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Rapid formation and selective stabilization of synapses for enduring motor memories

31 March 2020

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Synaptic dysfunction in Parkinson's disease.

31 March 2020

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The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia

31 March 2020

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Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein

31 March 2020

1 reference

Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements

31 March 2020

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Synapses and memory storage

31 March 2020

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Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines.

31 March 2020

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Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity

31 March 2020

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Dendritic spine changes associated with hippocampal long-term synaptic plasticity

31 March 2020

1 reference

BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex.

31 March 2020

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A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS.

31 March 2020

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Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning

31 March 2020

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Brain-derived neurotrophic factor in Huntington disease

31 March 2020

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Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

31 March 2020

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Brain-derived neurotrophic factor and neurotrophin-3 levels in Alzheimer's disease brains

31 March 2020

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Region-Specific Neurotrophin Imbalances in Alzheimer Disease

31 March 2020

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BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

31 March 2020

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Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

31 March 2020

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Acute intrahippocampal infusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentate gyrus.

31 March 2020

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Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus

31 March 2020

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Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice.

31 March 2020

1 reference

Inhibition of GABAA synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus

31 March 2020

2 references

31 March 2020

12 December 2020

Brain-derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of the hippocampus

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Presynaptic modulation of synaptic transmission and plasticity by brain-derived neurotrophic factor in the developing hippocampus.

31 March 2020

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Brain-derived neurotrophic factor enhances long-term potentiation in rat visual cortex.

31 March 2020

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Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex

31 March 2020

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Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor

31 March 2020

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Essential role of brain-derived neurotrophic factor in adult hippocampal function

31 March 2020

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Essential role for TrkB receptors in hippocampus-mediated learning

31 March 2020

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The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB.

31 March 2020

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Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons

31 March 2020

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BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?

31 March 2020

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A role for BDNF in the late-phase of hippocampal long-term potentiation

31 March 2020

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Activity-dependent release of endogenous brain-derived neurotrophic factor from primary sensory neurons detected by ELISA in situ

31 March 2020

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Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons.

31 March 2020

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Control of extracellular cleavage of ProBDNF by high frequency neuronal activity

31 March 2020

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Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs

31 March 2020

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Neurotrophins and time: different roles for TrkB signaling in hippocampal long-term potentiation

31 March 2020

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Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity

31 March 2020

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Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture.

31 March 2020

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TrkB as a potential synaptic and behavioral tag.

31 March 2020

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Neurotrophin regulation of neural circuit development and function

31 March 2020

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Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo

31 March 2020

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Neurotrophins regulate dendritic growth in developing visual cortex

31 March 2020

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Inhibition of ocular dominance column formation by infusion of NT-4/5 or BDNF.

31 March 2020

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Miniature synaptic transmission and BDNF modulate dendritic spine growth and form in rat CA1 neurones

31 March 2020

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Protein synthesis-dependent and -independent regulation of hippocampal synapses by brain-derived neurotrophic factor

31 March 2020

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Destabilization of cortical dendrites and spines by BDNF.

31 March 2020

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Lack of TrkB and TrkC signaling alters the synaptogenesis and maturation of mossy fiber terminals in the hippocampus.

31 March 2020

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BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2.

31 March 2020

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Altered balance of glutamatergic/GABAergic synaptic input and associated changes in dendrite morphology after BDNF expression in BDNF-deficient hippocampal neurons.

31 March 2020

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Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats.

31 March 2020

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Learning deficit in BDNF mutant mice.

31 March 2020

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A chemical-genetic approach to studying neurotrophin signaling

31 March 2020

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The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value

31 March 2020

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Signaling mechanisms mediating BDNF modulation of memory formation in vivo in the hippocampus.

31 March 2020

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Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning

31 March 2020

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A genetic variant BDNF polymorphism alters extinction learning in both mouse and human

31 March 2020

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Interaction between BDNF and serotonin: role in mood disorders

31 March 2020

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New insights into BDNF function in depression and anxiety

31 March 2020

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BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity.

31 March 2020

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Potential therapeutic uses of BDNF in neurological and psychiatric disorders

31 March 2020

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Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice.

31 March 2020

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Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

31 March 2020

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Neurotrophins enhance CaMKII activity and rescue amyloid-β-induced deficits in hippocampal synaptic plasticity

31 March 2020

1 reference

The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

31 March 2020

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Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior

31 March 2020

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The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology.

31 March 2020

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Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation.

31 March 2020

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Impact of brain-derived neurotrophic factor Val66Met polymorphism on cortical thickness and voxel-based morphometry in healthy Chinese young adults

31 March 2020

1 reference

BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals

31 March 2020

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A systematic review and meta-analysis on the association between BDNF val(66)met and hippocampal volume--a genuine effect or a winners curse?

31 March 2020

1 reference

Lower hippocampal volume in patients suffering from depression: a meta-analysis

31 March 2020

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Hippocampal volume and depression: a meta-analysis of MRI studies

31 March 2020

1 reference

Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor.

31 March 2020

1 reference

The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease.

31 March 2020

1 reference

Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults

31 March 2020

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High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment

31 March 2020

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Association between BDNF val66 met genotype and episodic memory.

31 March 2020

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Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers

31 March 2020

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Brain-derived neurotrophic factor polymorphism Val66Met influences cognitive abilities in the elderly.

31 March 2020

1 reference

Disturbances in selective information processing associated with the BDNF Val66Met polymorphism: evidence from cognition, the P300 and fronto-hippocampal systems

31 March 2020

1 reference

BDNF Val66Met and cognition: all, none, or some? A meta-analysis of the genetic association

31 March 2020

1 reference

Differential modulation of motor cortex excitability in BDNF Met allele carriers following experimentally induced and use-dependent plasticity.

31 March 2020

1 reference

Brain-derived neurotrophic factor (BDNF) gene polymorphisms shape cortical plasticity in humans

31 March 2020

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Interaction of BDNF and COMT polymorphisms on paired-associative stimulation-induced cortical plasticity.

31 March 2020

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Correlation between cortical plasticity, motor learning and BDNF genotype in healthy subjects.

31 March 2020

1 reference

The effects of prolonged cathodal direct current stimulation on the excitatory and inhibitory circuits of the ipsilateral and contralateral motor cortex.

31 March 2020

1 reference

Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity

31 March 2020

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The role of the BDNF Val66Met polymorphism for the synchronization of error-specific neural networks.

31 March 2020

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Association analysis of brain-derived neurotrophic factor (BDNF) gene 196 A/G polymorphism with Alzheimer's disease (AD) in mainland Chinese.

31 March 2020

1 reference

Role of BDNF Val66Met functional polymorphism in Alzheimer's disease-related depression.

31 March 2020

1 reference

BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

31 March 2020

1 reference

Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

31 March 2020

1 reference

Association of a variation in the promoter region of the brain-derived neurotrophic factor gene with familial Parkinson's disease

31 March 2020

1 reference

BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson's disease.

31 March 2020

1 reference

Brain-derived neurotrophic factor (BDNF) genetic polymorphism greatly increases risk of leucine-rich repeat kinase 2 (LRRK2) for Parkinson's disease.

31 March 2020

1 reference

The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus

31 March 2020

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Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex

31 March 2020

1 reference

Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivo

31 March 2020

1 reference

Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches

31 March 2020

1 reference

A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III)

31 March 2020

1 reference

A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis.

31 March 2020

1 reference

Is the therapeutic application of neurotrophic factors dead?

31 March 2020

1 reference

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

31 March 2020

1 reference

Pharmacokinetics of intrathecally applied BDNF and effects on spinal motoneurons.

31 March 2020

1 reference

The administration of BDNF and GDNF to the brain via PLGA microparticles patterned within a degradable PEG-based hydrogel: Protein distribution and the glial response.

31 March 2020

1 reference

Using polymer chemistry to modulate the delivery of neurotrophic factors from degradable microspheres: delivery of BDNF.

31 March 2020

1 reference

Genetic engineering, expression, and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier

31 March 2020

1 reference

Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin.

31 March 2020

1 reference

Identification and design of peptides as a new drug delivery system for the brain

31 March 2020

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Targeted delivery across the blood-brain barrier

31 March 2020

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Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium

31 March 2020

1 reference

From molecular to nanotechnology strategies for delivery of neurotrophins: emphasis on brain-derived neurotrophic factor (BDNF)

31 March 2020

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Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases

31 March 2020

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Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS.

31 March 2020

1 reference

Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats.

31 March 2020

1 reference

Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF.

31 March 2020

1 reference

Carboxyl-directed pegylation of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biologic activity

31 March 2020

1 reference

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.

31 March 2020

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Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

31 March 2020

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Novel agonist monoclonal antibodies activate TrkB receptors and demonstrate potent neurotrophic activities.

31 March 2020

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Appetite enhancement and weight gain by peripheral administration of TrkB agonists in non-human primates.

31 March 2020

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Solid-state NMR reveals structural changes in phospholamban accompanying the functional regulation of Ca2+-ATPase

31 March 2020

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Novel monocyclic and bicyclic loop mimetics of brain-derived neurotrophic factor.

31 March 2020

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Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures

31 March 2020

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Deoxygedunin, a natural product with potent neurotrophic activity in mice

31 March 2020

1 reference

TrkB agonists ameliorate obesity and associated metabolic conditions in mice

31 March 2020

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TrkB agonist antibody dose-dependently raises blood pressure in mice with diet-induced obesity

31 March 2020

1 reference

Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects.

31 March 2020

1 reference

The exercise-induced expression of BDNF within the hippocampus varies across life-span

31 March 2020

1 reference

Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments.

31 March 2020

1 reference

Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain

31 March 2020

1 reference

Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects.

31 March 2020

1 reference

Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade

31 March 2020

1 reference

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

31 March 2020

1 reference

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

31 March 2020

1 reference

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

31 March 2020

1 reference

The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain

31 March 2020

1 reference

Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer's disease

31 March 2020

1 reference

Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus

31 March 2020

1 reference

ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons.

31 March 2020

1 reference

Effect of the brain-derived neurotrophic factor and the apolipoprotein E polymorphisms on disease progression in preclinical Alzheimer's disease.

31 March 2020

1 reference

Hippocampal deletion of BDNF gene attenuates gamma oscillations in area CA1 by up-regulating 5-HT3 receptor

31 March 2020

1 reference

TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus

31 March 2020

1 reference

Conversion from mild cognitive impairment to Alzheimer's disease is predicted by sources and coherence of brain electroencephalography rhythms.

31 March 2020

1 reference

The role of event-related potentials in cognitive decline in Alzheimer's disease.

31 March 2020

1 reference

Alzheimer's research. Stopping Alzheimer's before it starts

31 March 2020

1 reference

Clinical and biomarker changes in dominantly inherited Alzheimer's disease

31 March 2020

1 reference

Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study

31 March 2020

1 reference

Dopaminergic agonists in Parkinson's disease

31 March 2020

1 reference

Brain-derived neurotrophic factor (BDNF) protects cultured rat cerebellar granule neurons against glucose deprivation-induced apoptosis.

31 March 2020

1 reference

Nerve growth factor and brain-derived neurotrophic factor but not granulocyte colony-stimulating factor, nimodipine and dizocilpine, require ATP for neuroprotective activity after oxygen-glucose deprivation of primary neurons.

31 March 2020

1 reference

The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death

31 March 2020

1 reference

Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity

31 March 2020

1 reference

Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats.

31 March 2020

1 reference

Brain-derived neurotrophic factor but not forced arm use improves long-term outcome after photothrombotic stroke and transiently upregulates binding densities of excitatory glutamate receptors in the rat brain

31 March 2020

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Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat.

31 March 2020

1 reference

BDNF attenuates the effects of intrastriatal injection of 6-hydroxydopamine

31 March 2020

1 reference

Neuroprotective effects of brain-derived neurotrophic factor in seizures during development.

31 March 2020

1 reference

TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses.

31 March 2020

1 reference

Population genetic study of the brain-derived neurotrophic factor (BDNF) gene

31 March 2020

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Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: the possibility to explain ethnic mental traits.

31 March 2020

1 reference

Effect of Met66 allele of the BDNF rs6265 SNP on regional gray matter volumes in patients with multiple sclerosis: A voxel-based morphometry study

31 March 2020

1 reference

Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder

31 March 2020

1 reference

Linkage Disequilibrium of the Brain-Derived Neurotrophic FactorVal66MetPolymorphism in Children With a Prepubertal and Early Adolescent Bipolar Disorder Phenotype

31 March 2020

1 reference

TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections.

31 March 2020

1 reference

N-acetylserotonin activates TrkB receptor in a circadian rhythm

31 March 2020

1 reference

Activation of Trk neurotrophin receptors in the absence of neurotrophins

31 March 2020

1 reference

Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides

31 March 2020

1 reference

Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells.

31 March 2020

1 reference

Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse

31 March 2020

1 reference

Design of a conformationally defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor.

31 March 2020

1 reference

RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB

31 March 2020

1 reference

Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons.

31 March 2020

1 reference

Chronic elevation of brain-derived neurotrophic factor by ampakines

31 March 2020

1 reference

Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression

31 March 2020

1 reference

Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator.

31 March 2020

1 reference

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus.

31 March 2020

1 reference

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome.

31 March 2020

1 reference

CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice

31 March 2020

1 reference

Evidence for a release of brain-derived neurotrophic factor from the brain during exercise.

31 March 2020

1 reference

Pharmacological evidence of cholinergic involvement in adult hippocampal neurogenesis in rats.

31 March 2020

1 reference

Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice.

31 March 2020

1 reference

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

31 March 2020

1 reference

Brain-derived neurotrophic factor antisense oligonucleotide impairs memory retention and inhibits long-term potentiation in rats.

31 March 2020

1 reference

12 December 2020

Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target

1 reference

12 December 2020

Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat.

1 reference

12 December 2020

Dimebon alters hippocampal amyloid pathology in 3xTg-AD mice.

1 reference

12 December 2020

Relative contribution of endogenous neurotrophins in hippocampal long-term potentiation.

1 reference

12 December 2020

The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies.

1 reference

12 December 2020

Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand?

1 reference

12 December 2020

Design of Potent Peptide Mimetics of Brain-derived Neurotrophic Factor

1 reference

12 December 2020

Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks

1 reference

12 December 2020

Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice.

1 reference

12 December 2020

Towards non invasive nerve growth factor therapies for Alzheimer's disease

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12 December 2020

Polymorphism of brain derived neurotrophic factor influences β amyloid load in cognitively intact apolipoprotein E ε4 carriers

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12 December 2020

Identifiers

DOI

10.1038/NRN3505

1 reference

Dimensions Publication ID

1 August 2017

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