(Q34347768)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

ChEBI release 2020-05-28

ChEBI ID

78661

angiogenesis inhibitor

1 reference

alternative mRNA splicing, via spliceosome

inferred from title

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Neil Dixon

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Jason Micklefield

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Matt Gregory

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Peter Leadlay

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

David O. Bates

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

William Vousden

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Steven J Moss

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Arjun Krishnakumar

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Melissa Vr Gammons

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

David G Nowak

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Astrid Spannhoff

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Mark T Bedford

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Christine J Martin

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Ming Q Zhang

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Steven J Harper

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Barrie Wilkinson

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

publication date

1 February 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

273-278

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

8 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3399765/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

VEGF-A splicing: the key to anti-angiogenic therapeutics?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

Searching for a wrench to throw into the splicing machine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

Cellular targets of natural products

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

WW domains provide a platform for the assembly of multiprotein networks

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

A protein-domain microarray identifies novel protein-protein interactions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

Identification of hNopp140 as a binding partner for doxorubicin with a phage display cloning method

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

Establishment of a quantitative mouse dorsal air sac model and its application to evaluate a new angiogenesis inhibitor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

Chinese hamster ovary cells resistant to borrelidin overproduce threonyl-tRNA synthetase.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases

6 July 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0SC00297F

Simultaneous identification of multiple protein targets by using complementary-DNA phage display and a natural-product-mimetic probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0SC00297F

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0SC00297F

Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0SC00297F

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0SC00297F

The anti-angiogenic isoforms of VEGF in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0SC00297F

Differential inhibition of single and cluster type tumor cell migration

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399765

Preparation of efficient splicing extracts from whole cells, nuclei, and cytoplasmic fractions

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22822423

12 December 2020

inferred from PubMed ID database lookup

The anti-borrelia effect of borrelidin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22822423

12 December 2020

inferred from PubMed ID database lookup

The endogenous anti-angiogenic family of splice variants of VEGF, VEGFxxxb, are down-regulated in pre-eclamptic placentae at term

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22822423

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1039/C0SC00297F

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22822423%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

22822423

1 reference