(Q34358984)

1 August 2017

title

The metabolism of mexiletine in relation to the debrisoquine/sparteine-type polymorphism of drug oxidation (English)

1 reference

1 August 2017

Broly F

1

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1 August 2017

Vandamme N

series ordinal

2

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1 August 2017

Libersa C

series ordinal

3

1 reference

1 August 2017

Lhermitte M

series ordinal

4

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1 August 2017

language of work or name

English

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publication date

1 October 1991

1 reference

British Journal of Clinical Pharmacology

1 August 2017

published in

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1 August 2017

volume

32

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1 August 2017

issue

4

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1 August 2017

page(s)

459-466

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Protein measurement with the Folin phenol reagent

1 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

Kinetics and bioavailability of mexiletine in healthy subjects

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

Genetic variation in rates of antipyrine metabolite formation: a study in uninduced twins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

Clinical pharmacokinetics of the newer antiarrhythmic agents

6 July 2018

1 reference

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Practical considerations in the treatment of ventricular arrhythmias with mexiletine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

The use of mass spectroscopy and 13C and 1H nuclear magnetic resonance in the characterization of 1-methyl-(2, 6-xylyloxy)ethylamine metabolites.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

Treatment of ventricular arrhythmias with mexiletine (Kö 1173).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

A family study of genetic and environmental factors determining polymorphic hydroxylation of debrisoquin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

Phenacetin O-deethylase: an activity of a cytochrome P-450 showing genetic linkage with that catalysing the 4-hydroxylation of debrisoquine?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

Pharmacogenetics of dextromethorphan O-demethylation in man.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

Relationship between plasma mexiletine levels at steady-state. Presence of ventricular arrhythmias and side effects.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

Effect of quinidine on the dextromethorphan O-demethylase activity of microsomal fractions from human liver

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

Mexiletine metabolism in vitro by human liver.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

Mexiletine in normal volunteers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

The clinical pharmacology of mexiletine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

Long-term treatment of ventricular arrhythmias with oral mexiletine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

The effect of spontaneous changes in urinary pH on mexiletine plasma concentrations and excretion during chronic administration to healthy volunteers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

The distribution, metabolism and excretion of mexiletine in man

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

Variable pharmacokinetics of mexiletine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

The identification and analysis of mexiletine and its metabolic products in man

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368606

Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1365-2125.1991.TB03931.X

Pharmacology, electrophysiology, and pharmacokinetics of mexiletine

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1365-2125.1991.TB03931.X

Metabolism of methoxyphenamine in extensive and poor metabolizers of debrisoquin

21 January 2018

1 reference

12 December 2020

High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

1 reference

12 December 2020

Inhibitory studies of mexiletine and dextromethorphan oxidation in human liver microsomes

1 reference

12 December 2020

Determination of debrisoquine and its 4-hydroxy metabolite in biological fluids by gas chromatography with flame-ionization and nitrogen-selective detection

1 reference

12 December 2020

Absorption, distribution and elimination of mexiletine

1 reference

12 December 2020

Effect of rifampicin treatment on the kinetics of mexiletine

1 reference

12 December 2020

Effect of cigarette smoking on mexiletine kinetics

1 reference

12 December 2020

In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase

1 reference

12 December 2020

10.1111/J.1365-2125.1991.TB03931.X

Identifiers

DOI

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1 August 2017

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1 August 2017

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