(Q34360755)

1 August 2017

title

R-spondin1 is a novel hormone mediator for mammary stem cell self-renewal (English)

1 reference

1 August 2017

main subject

stem cell self-renewal

1 reference

Cheguo Cai

1

1 reference

1 August 2017

Qing Cissy Yu

2

1 reference

1 August 2017

Weimin Jiang

3

1 reference

1 August 2017

Wei Liu

4

1 reference

1 August 2017

Wenqian Song

5

1 reference

1 August 2017

Hua Yu

6

1 reference

1 August 2017

Lei Zhang

7

1 reference

1 August 2017

Ying Yang

8

1 reference

1 August 2017

Yi Arial Zeng

9

1 reference

1 August 2017

publication date

26 September 2014

1 reference

1 August 2017

1 reference

1 August 2017

volume

28

1 reference

1 August 2017

issue

20

1 reference

1 August 2017

page(s)

2205-2218

1 reference

A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway

1 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.

6 July 2018

1 reference

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WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Fibroblast-dependent regulation of the stem cell properties of cancer cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Wnt/β-catenin signaling and disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Mouse estrous cycle identification tool and images

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Interactions between cancer stem cells and their niche govern metastatic colonization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

WNT11 Expression Is Induced by Estrogen-Related Receptor α and β-Catenin and Acts in an Autocrine Manner to Increase Cancer Cell Migration

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Progesterone induces adult mammary stem cell expansion

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Wnt4 is not sufficient to induce lobuloalveolar mammary development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Genetics of ovarian differentiation: Rspo1, a major player

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

R-Spondin family members regulate the Wnt pathway by a common mechanism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Stem cells and niches: mechanisms that promote stem cell maintenance throughout life

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Steroid hormone receptor status of mouse mammary stem cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Generation of a functional mammary gland from a single stem cell

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Purification and unique properties of mammary epithelial stem cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Mitogenic influence of human R-spondin1 on the intestinal epithelium

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Wnt proteins are lipid-modified and can act as stem cell growth factors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

In situ identification of bipotent stem cells in the mammary gland.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Control of mammary stem cell function by steroid hormone signalling.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Estrogen-triggered delays in mammary gland gene expression during the estrous cycle: evidence for a novel timing system

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Identification of the mammary line in mouse by Wnt10b expression.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

IGF-2 is a mediator of prolactin-induced morphogenesis in the breast

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

Developmental and hormonal regulation of Wnt gene expression in the mouse mammary gland.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201283

The pattern of beta-catenin responsiveness within the mammary gland is regulated by progesterone receptor

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25260709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

R-spondin1 is required for normal epithelial morphogenesis during mammary gland development

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25260709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.245142.114

1 reference

1 August 2017

1 reference

1 August 2017

1 reference