(Q34372472)

1 August 2017

title

Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania (English)

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1 August 2017

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A L Bodley

1

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1 August 2017

T A Shapiro

series ordinal

2

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1 August 2017

language of work or name

English

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publication date

1 April 1995

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Proceedings of the National Academy of Sciences of the United States of America

1 August 2017

published in

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1 August 2017

volume

92

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1 August 2017

issue

9

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1 August 2017

page(s)

3726-3730

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Preclinical and clinical development of camptothecins

1 August 2017

cites work

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The current status of camptothecin analogues as antitumor agents

6 July 2018

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Phylogenetic analysis of RNA editing: a primitive genetic phenomenon

6 July 2018

1 reference

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Evolution of nuclear ribosomal RNAs in kinetoplastid protozoa: perspectives on the age and origins of parasitism

6 July 2018

1 reference

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Mitochondrial topoisomerase II activity is essential for kinetoplast DNA minicircle segregation

6 July 2018

1 reference

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Evolution of RNA editing in kinetoplastid protozoa

6 July 2018

1 reference

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Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models

6 July 2018

1 reference

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Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide

6 July 2018

1 reference

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Intracellular degradation of HeLa and adenovirus type 2 DNA induced by camptothecin

6 July 2018

1 reference

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Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro

6 July 2018

1 reference

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Topoisomerase inhibitors can selectively interfere with different stages of simian virus 40 DNA replication

6 July 2018

1 reference

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ATP-independent type II topoisomerase from trypanosomes

6 July 2018

1 reference

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DNA topoisomerases: enzymes that control DNA conformation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

Isolation and functional characterization of murine T cell lines and clones specific for the protozoan parasite Trypanosoma cruzi

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

Replication of kinetoplast DNA in trypanosomes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

6 July 2018

1 reference

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DNA topoisomerase-targeting antitumor drugs can be studied in yeast

6 July 2018

1 reference

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The mitochondrial genome of kinetoplastid protozoa: genomic organization, transcription, replication, and evolution

6 July 2018

1 reference

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Kinetoplast DNA minicircles: high-copy-number mitochondrial plasmids

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

Biochemical characteristics and physiological significance of major DNA topoisomerases

6 July 2018

1 reference

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DNA topoisomerases as anticancer drug targets

6 July 2018

1 reference

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The TOP2 gene of Trypanosoma brucei: a single-copy gene that shares extensive homology with other TOP2 genes encoding eukaryotic DNA topoisomerase II.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

DNA topoisomerases: why so many?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells

6 July 2018

1 reference

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High-efficiency clonal growth of bloodstream- and insect-form Trypanosoma brucei on agarose plates

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

Cloning and characterization of the gene encoding Trypanosoma cruzi DNA topoisomerase II.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

Molecular cloning and expression of the gene encoding the kinetoplast-associated type II DNA topoisomerase of Crithidia fasciculata

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

In vivo inhibition of trypanosome mitochondrial topoisomerase II: effects on kinetoplast DNA maxicircles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

On the DNA content and ploidy of trypanosomes

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

Localization of a type II DNA topoisomerase to two sites at the periphery of the kinetoplast DNA of Crithidia fasciculata

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

Drug-promoted cleavage of kinetoplast DNA minicircles. Evidence for type II topoisomerase activity in trypanosome mitochondria.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

Novobiocin affinity purification of a mitochondrial type II topoisomerase from the trypanosomatid Crithidia fasciculata.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=42034

Complete growth inhibition of human cancer xenografts in nude mice by treatment with 20-(S)-camptothecin

27 October 2018

1 reference

12 December 2020

Complete inhibition of growth followed by death of human malignant melanoma cells in vitro and regression of human melanoma xenografts in immunodeficient mice induced by camptothecins

1 reference

12 December 2020

Structural modifications of camptothecin and effects on topoisomerase I inhibition

1 reference

12 December 2020

A type 1 DNA topoisomerase from the kinetoplast hemoflagellate Leishmania donovani

1 reference

12 December 2020

Fighting parasites on a shoestring

1 reference

12 December 2020

Total synthesis of natural 20(S)-camptothecin

1 reference

12 December 2020

A type I DNA topoisomerase from Trypanosoma cruzi

1 reference

12 December 2020

A Unique ATP-Dependent DNA Topoisomerase from Trypanosomatids

1 reference

12 December 2020

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

12 December 2020

Purification and nuclear localization of a type I topoisomerase from Crithidia fasciculata

1 reference

12 December 2020

Decatenation of kinetoplast DNA by an ATP-dependent DNA topoisomerase from the kinetoplast hemoflagellate Leishmania donovani

1 reference

12 December 2020

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

1 reference

12 December 2020

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons

1 reference

12 December 2020

Acid phosphatase: endpoint for in vitro toxicity tests

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.92.9.3726

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1 August 2017

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1 August 2017

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