(Q34374214)

1 August 2017

title

The assembly-inducing laulimalide/peloruside a binding site on tubulin: molecular modeling and biochemical studies with [³H]peloruside A. (English)

1 reference

1 August 2017

Tam Luong Nguyen

1

1 reference

1 August 2017

Xiaoming Xu

2

1 reference

1 August 2017

Rick Gussio

3

1 reference

1 August 2017

Arun K Ghosh

4

1 reference

1 August 2017

Ernest Hamel

5

1 reference

1 August 2017

publication date

28 October 2010

1 reference

Journal of Chemical Information and Modeling

1 August 2017

published in

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1 August 2017

volume

50

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1 August 2017

issue

11

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1 August 2017

page(s)

2019-2028

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Molecular Recognition of Peloruside A by Microtubules. The C24 Primary Alcohol is Essential for Biological Activity

1 August 2017

cites work

1 reference

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Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping

6 July 2018

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Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity

6 July 2018

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Evaluating transition-metal-catalyzed transformations for the synthesis of laulimalide

6 July 2018

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Function-oriented synthesis: biological evaluation of laulimalide analogues derived from a last step cross metathesis diversification strategy

6 July 2018

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A unique mode of microtubule stabilization induced by peloruside A

6 July 2018

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Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.

6 July 2018

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NMR determination of the bioactive conformation of peloruside A bound to microtubules.

6 July 2018

1 reference

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Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site

6 July 2018

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Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain.

6 July 2018

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Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines

6 July 2018

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Microtubule-stabilizing agents based on designed laulimalide analogues

6 July 2018

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Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity

6 July 2018

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Synthesis and biological evaluation of (-)-laulimalide analogues

6 July 2018

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Mutational analysis of the class I beta-tubulin gene in human breast cancer

6 July 2018

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Refined structure of alpha beta-tubulin at 3.5 A resolution

6 July 2018

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Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents.

6 July 2018

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The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells

6 July 2018

1 reference

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Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.

6 July 2018

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Taxol stabilizes microtubules in mouse fibroblast cells

6 July 2018

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HINT: a new method of empirical hydrophobic field calculation for CoMFA.

6 July 2018

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Promotion of microtubule assembly in vitro by taxol

6 July 2018

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Heat capacity and entropy changes in processes involving proteins

6 July 2018

1 reference

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The laulimalide family: total synthesis and biological evaluation of neolaulimalide, isolaulimalide, laulimalide and a nonnatural analogue.

6 July 2018

1 reference

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Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996141

A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996141

The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996141

Laulimalide and paclitaxel: a comparison of their effects on tubulin assembly and their synergistic action when present simultaneously

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996141

Total synthesis of the microtubule stabilizing antitumor agent laulimalide and some nonnatural analogues: the power of Sharpless' asymmetric epoxidation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996141

The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996141

Total synthesis of microtubule-stabilizing agent (-)-laulimalide

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996141

The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996141

Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996141

Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996141

Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity

27 October 2018

1 reference

12 December 2020

Synthesis and biological evaluation of (-)-laulimalide analogues

1 reference

12 December 2020

Deoxyguanosine nucleotide analogues: potent stimulators of microtubule nucleation with reduced affinity for the exchangeable nucleotide site of tubulin

1 reference

12 December 2020

The magnesium-GTP interaction in microtubule assembly

1 reference

12 December 2020

Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue

1 reference

12 December 2020

Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore

1 reference

12 December 2020

Enantioselective total synthesis of peloruside A: a potent microtubule stabilizer

1 reference

12 December 2020

Identifiers

DOI

10.1021/CI1002894

1 reference

journals/jcisd/NguyenXGGH10

1 August 2017

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

1 August 2017

1 reference