(Q34390191)

1 August 2017

1 reference

title

Activation and signaling of the p38 MAP kinase pathway (English)

1 reference

1 August 2017

Tyler Zarubin

1

1 reference

PubMed ID

15686620

1 August 2017

Jiahuai Han

series ordinal

2

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1 August 2017

1 January 2005

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1 August 2017

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1 August 2017

15

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1 August 2017

11-18

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1 August 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.cr.7290257

1 August 2017

0 references

cites work

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

The primary structure of p38 gamma: a new member of p38 group of MAP kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

An osmosensing signal transduction pathway in yeast.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

P38 Mitogen Activated Protein Kinase Regulates Endothelial VCAM-1 Expression at the Post-transcriptional Level

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Interleukin 18 stimulates HIV type 1 in monocytic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Inhibition of p38 mitogen-activated protein kinase by insulin in cultured fetal neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Identification of stathmin as a novel substrate for p38 delta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Mechanism of p38 MAP kinase activation in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Regulation of the maintenance of peripheral T-cell anergy by TAB1-mediated p38 alpha activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Activation of discoidin domain receptor 1 facilitates the maturation of human monocyte-derived dendritic cells through the TNF receptor associated factor 6/TGF-beta-activated protein kinase 1 binding protein 1 beta/p38 alpha mitogen-activated protei

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Identification of a mouse p21Cdc42/Rac activated kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

A two-component system that regulates an osmosensing MAP kinase cascade in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

PRAK, a novel protein kinase regulated by the p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Cloning and characterization of RLPK, a novel RSK-related protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Convergence of MAP kinase pathways on the ternary complex factor Sap-1a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Regulation of the MEF2 family of transcription factors by p38

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

The HBP1 transcriptional repressor and the p38 MAP kinase: unlikely partners in G1 regulation and tumor suppression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

A role for the p38 MAP kinase pathway in the nuclear shuttling of NFATp

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

p38 Kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+/H+ exchange and ERK1/2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Reactivating kinase/p38 phosphorylates tau protein in vitro.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Signal transduction in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

The p38 MAP kinase signaling pathway in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

ICE family proteases: mediators of all apoptotic cell death?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

The regulation of anoikis: MEKK-1 activation requires cleavage by caspases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiring p38/RK.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

p38 MAPK signaling during murine preimplantation development.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290257

7 January 2021

Identifiers

DOI

10.1038/SJ.CR.7290257

1 reference

PubMed ID

15686620

Dimensions Publication ID

1 August 2017

0 references

1 reference

PubMed ID

15686620