(Q34395427)

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Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s).

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Europe PubMed Central

PubMed publication ID

1 August 2017

Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s). (English)

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PubMed publication ID

1 August 2017

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author name string

Michael P Johnson

1

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1 August 2017

David Barda

2

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1 August 2017

Thomas C Britton

3

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1 August 2017

Renee Emkey

4

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1 August 2017

William J Hornback

5

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1 August 2017

G Erik Jagdmann

6

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1 August 2017

David L McKinzie

7

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1 August 2017

Eric S Nisenbaum

8

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1 August 2017

Joseph P Tizzano

9

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1 August 2017

Darryle D Schoepp

10

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1 August 2017

publication date

17 February 2005

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1 August 2017

Psychopharmacology

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1 August 2017

179

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1 August 2017

1

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1 August 2017

271-283

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1 August 2017

https://scigraph.springernature.com/pub.10.1007/s00213-004-2099-9

0 references

Recent advances in the phencyclidine model of schizophrenia

1 reference

https://api.crossref.org/works/10.1007%2FS00213-004-2099-9

21 January 2018

The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501

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https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

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The phencyclidine-glutamate model of schizophrenia.

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https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

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Tolerance to the motor impairment, but not to the reversal of PCP-induced motor activities by oral administration of the mGlu2/3 receptor agonist, LY379268

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

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Metabotropic glutamate receptor-mediated presynaptic depression at corticostriatal synapses involves mGLuR2 or 3

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

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Striatal metabotropic glutamate receptor function following experimental parkinsonism and chronic levodopa treatment

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https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

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Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxioly

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The group II metabotropic glutamate receptor agonist (-)-2-oxa-4-aminobicyclo[3.1.0.]hexane-4,6-dicarboxylate (LY379268) and clozapine reverse phencyclidine-induced behaviors in monoamine-depleted rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

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Alkyl diphenylacetyl, 9H-xanthene- and 9H-thioxanthene-carbonyl carbamates as positive allosteric modulators of mGlu1 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

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A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

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Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model for the functioning of family 3 GPCRs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Group 2 metabotropic glutamate receptors induced long term depression in mouse striatal slices.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Difference in mGluR5 interaction between positive allosteric modulators from two structural classes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

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The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

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Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

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The effects of DCG-IV and L-CCG-1 upon phencyclidine (PCP)-induced locomotion and behavioral changes in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine and 5-HT turnover are increased by the mGlu2/3 receptor agonist LY379268 in rat medial prefrontal cortex, nucleus accumbens and striatum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the mGlu2/3 receptor agonist LY379268 on motor activity in phencyclidine-sensitized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between LY354740, a group II metabotropic agonist and the GABA(A)-benzodiazepine receptor complex in the rat elevated plus-maze

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model to measure anticipatory anxiety in mice?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

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SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGlu(2/3) receptor agonist LY379268 selectively blocks amphetamine ambulations and rearing

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGlu2/3 receptor agonist LY379268 blocks the expression of locomotor sensitization by amphetamine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: review article

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G protein-coupled receptor allosterism and complexing

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGlu2/3 receptor agonist, LY354740, blocks immobilization-induced increases in noradrenaline and dopamine release in the rat medial prefrontal cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute increases in monoamine release in the rat prefrontal cortex by the mGlu2/3 agonist LY379268 are similar in profile to risperidone, not locally mediated, and can be elicited in the presence of uptake blockade

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

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The potent, selective mGlu2/3 receptor agonist LY379268 increases extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindole-3-acetic acid in the medial prefrontal cortex of the freely moving rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

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Visualizing unstained neurons in living brain slices by infrared DIC-videomicroscopy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

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LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-004-2099-9

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

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