(Q34400492)

1 August 2017

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title

Preclinical development of neurosteroids as neuroprotective agents for the treatment of neurodegenerative diseases (English)

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1 August 2017

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Lapchak PA

1

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1 August 2017

Araujo DM

series ordinal

2

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1 August 2017

publication date

1 January 2001

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International Review of Neurobiology

1 August 2017

published in

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1 August 2017

volume

46

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1 August 2017

page(s)

379-397

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Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury

1 August 2017

cites work

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Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease.

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7 January 2021

The effect of dehydroepiandrosterone sulfate administration to patients with multi-infarct dementia.

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7 January 2021

The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life.

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7 January 2021

The cholinergic hypothesis of geriatric memory dysfunction

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7 January 2021

Neurosteroids: a novel function of the brain.

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7 January 2021

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

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7 January 2021

Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors.

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7 January 2021

Dehydroepiandrosterone sulphate (DHEAS) in the oldest old, aged 85 and over.

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7 January 2021

Dehydroepiandrosterone and its sulfated derivative reduce neuronal death and enhance astrocytic differentiation in brain cell cultures.

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7 January 2021

The neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one induces cytoarchitectural regression in cultured fetal hippocampal neurons

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7 January 2021

Dehydroepiandrosterone sulphate and dehydroepiandrosterone in serum: differences related to age and sex

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7 January 2021

Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists

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7 January 2021

Pregnenolone and its sulfate ester in the rat brain

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7 January 2021

Differential effects of sigma ligands on the N-methyl-D-aspartate response in the CA1 and CA3 regions of the dorsal hippocampus: effect of mossy fiber lesioning.

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7 January 2021

Modulation of NMDA and dopaminergic neurotransmissions by sigma ligands: possible implications for the treatment of psychiatric disorders

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7 January 2021

Microvascular responses to cerebral ischemia/inflammation

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7 January 2021

The neurosteroid dehydroepiandrosterone sulfate (DHEAS) enhances hippocampal primed burst, but not long-term, potentiation.

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7 January 2021

Effects of dehydroepiandrosterone sulfate and stress on hippocampal electrophysiological plasticity

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7 January 2021

The enhancement of hippocampal primed burst potentiation by dehydroepiandrosterone sulfate (DHEAS) is blocked by psychological stress.

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7 January 2021

Pregnenolone sulfate potentiation of NMDA-mediated increases in intracellular calcium in cultured chick cortical neurons

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7 January 2021

Inflammatory gene expression in cerebral ischemia and trauma. Potential new therapeutic targets

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7 January 2021

Dehydroepiandrosterone sulfate improves memory in aging mice.

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7 January 2021

Dehydroepiandrosterone and its sulfate enhance memory retention in mice

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https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

The neurosteroids DHEA and DHEAS may influence cognitive performance by altering affective state.

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https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Neurosteroids Affect Spatial/Reference, Working, and Long-Term Memory of Female Rats

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https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Neurodegeneration and aging: role of the second genome

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https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Modulation of the GABA receptor complex by a steroid anaesthetic

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https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Neuroprotective therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit

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https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

The role of cerebral ischemia in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

A prospective study on cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly

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https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

DHEA and DHEA-S: a review

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2-week dehydroepiandrosterone treatment.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Neurosteroids and GABAA receptor function.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Identification and characterization of a pregnane steroid recognition site that is functionally coupled to an expressed GABAA receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Differential responses of expressed recombinant human gamma-aminobutyric acidA receptors to neurosteroids

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABA(A) receptors

1 reference

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7 January 2021

GABA antagonists differentiate between recombinant GABAA/benzodiazepine receptor subtypes

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7 January 2021

GABAA/Benzodiazepine receptor heterogeneity: Neurophysiological implications

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7 January 2021

Effect of gamma-aminobutyric acid modulation on neuronal ischemia in rabbits

1 reference

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7 January 2021

Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Neuronal actions of dehydroepiandrosterone. Possible roles in brain development, aging, memory, and affect

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Steroid control of uterine motility via gamma-aminobutyric acidA receptors in the rabbit: a novel mechanism?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Neuroprotection by dehydroepiandrosterone-sulfate: role of an NFkappaB-like factor

1 reference

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7 January 2021

Neurosteroid modulation of embryonic neuronal survival in vitro following anoxia.

1 reference

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7 January 2021

The neurosteroid pregnenolone sulfate blocks deficits induced by a competitive NMDA antagonist in active avoidance and lever-press learning tasks in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Dehydroepiandrosterone sulfate attenuates dizocilpine-induced learning impairment in mice via sigma 1-receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Dehydroepiandrosterone is an anxiolytic in mice on the plus maze.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Glutamate receptors: brain function and signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Neurosteroids act on recombinant human GABAA receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Synthesis, metabolism, and pharmacological activity of 3 alpha-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

A proposal for the classification of sigma binding sites

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

The role of GABA-A and mitochondrial diazepam-binding inhibitor receptors on the effects of neurosteroids on food intake in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Functional evidence for two native GABAA receptor subtypes in adult rat hippocampus and cerebellum.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Neurosteroids may differentially affect the function of two native GABA(A) receptor subtypes in the rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Effects of subunit types of the cloned GABAA receptor on the response to a neurosteroid

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Senile dementia of the Alzheimer type

1 reference

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7 January 2021

Expression of interleukin-6, c-fos, and zif268 mRNAs in rat ischemic cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Actions of dehydroepiandrosterone and its sulfate in the central nervous system: effects on cognition and emotion in animals and humans

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Opposing effects of DHEA replacement in elderly subjects on declarative memory and attention after exposure to a laboratory stressor.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Effects of dehydroepiandrosterone replacement in elderly men on event-related potentials, memory, and well-being

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Neuropsychiatric function and dehydroepiandrosterone sulfate in elderly women: a prospective study

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Spectrum of neurological deficits in experimental CNS ischemia. A quantitative study.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Quantal bioassay and stroke

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

Stimulus-transcription coupling in focal cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2801%2946069-7

7 January 2021

10.1016/S0074-7742(01)46069-7

Identifiers

DOI

1 reference

1 August 2017

1 reference