(Q34405320)

English

Antiaging compounds: (-)deprenyl (selegeline) and (-)1-(benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective highly potent enhancer of the impulse propagation mediated release of catecholamine and serotonin in the brain.

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607046%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

Europe PubMed Central

Antiaging compounds: (-)deprenyl (selegeline) and (-)1-(benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective highly potent enhancer of the impulse propagation mediated release of catecholamine and serotonin in the brain (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607046%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

author name string

J Knoll

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607046%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

publication date

1 January 2001

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607046%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

CNS Neuroscience & Therapeutics

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607046%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607046%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607046%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

317-345

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607046%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Apoptotic mechanisms in neurodegeneration: possible relevance to glaucoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does selegiline modify the progression of early Parkinson's disease? Results from a five-year study. The Norwegian-Danish Study Group.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)1-(Benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of deprenyl-insensitive apoptosis of nigral dopamine neurons during development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of L-deprenyl against apoptosis induced by okadaic acid in cultured neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extension of lifespan in mice treated with Dinh lang (Policias fruticosum L.) and (-)deprenyl

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental studies on the higher nervous activity of animals. VI. Further studies on active reflexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology of 1-phenyl-2-propylamino-pentane (PPAP), a deprenyl-derived new spectrum psychostimulant

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological basis of the therapeutic effect of (-)deprenyl in age-related neurological diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)Deprenyl increases activities of superoxide dismutase and catalase in striatum but not in hippocampus: the sex and age-related differences in the optimal dose in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-type dementia and verbal memory performances: influence of selegiline therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(−)Deprenyl and (−)parafluorodeprenyl-treatment prevents age-related pigment changes in the substantia nigra. A TV-image analysis of neuromelanin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CBF and cognitive evaluation of Alzheimer type patients before and after IMAO-B treatment: a pilot study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selegiline as initial treatment in de novo parkinsonian patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-Deprenyl Therapy Improves Verbal Memory in Amnesic Alzheimer Patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selegiline in de novo parkinsonian patients: the French selegiline multicenter trial (FSMT)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selegiline hydrochloride and cognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-) deprenyl induces activities of both superoxide dismutase and catalase but not of glutathione peroxidase in the striatum of young male rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a MAO-B inhibitor in the treatment of Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selegiline (deprenyl) treatment and death of nigral neurons in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of selegiline in Alzheimer's patients with behavior problems.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pilot study of low-dose L-deprenyl in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropsychological effects of L-deprenyl in Alzheimer's type dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maintenance on L-deprenyl prolongs life in aged male rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against DSP-4-induced neurotoxicity by deprenyl is not related to its inhibition of MAO B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selegiline versus L-acetylcarnitine in the treatment of Alzheimer-type dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selegiline in the treatment of mild to moderate Alzheimer-type dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nigrostriatal dopaminergic activity, deprenyl treatment, and longevity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selegiline versus oxiracetam in patients with Alzheimer-type dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of deprenyl (selegiline) on the natural history of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Striatal dopamine, sexual activity and lifespan. Longevity of rats treated with (-)deprenyl

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of deprenyl on the progression of disability in early Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-deprenyl in Alzheimer's disease. Preliminary evidence for behavioral change with monoamine oxidase B inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brief information on an early phase-II study with deprenyl in demented patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased life expectancy resulting from addition of L-deprenyl to Madopar treatment in Parkinson's disease: a longterm study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenylisopropylmethylpropinylamine (E-250), a new spectrum psychic energizer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some puzzling pharmacological effects of monoamine oxidase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition by deprenyl of dopamine uptake in rat striatum: a possible correlation between dopamine uptake and acetylcholine release inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical trial of a new type promptly acting psychoenergetic agent (phenyl-isopropyl-methylpropinyl-HCl, "E-250")

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amphetamine, p-hydroxyamphetamine and β-phenethylamine in mouse brain and urine after (−)- and (+)-deprenyl administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-lasting, true aphrodisiac effect of (-)-deprenyl in sexually sluggish old male rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-deprenyl plus L-phenylalanine in the treatment of depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deprenyl (selegiline): the history of its development and pharmacological action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implications of combined treatment with 'Madopar' and L-deprenil in Parkinson's disease. A long-term study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-deprenyl, a selective monoamine oxidase type-B inhibitor in endogenous depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deprenyl is metabolized to methamphetamine and amphetamine in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The possible mechanisms of action of (-)deprenyl in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of "cheese effect" during deprenyl therapy: some recent studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rationale for (-)deprenyl (selegiline) medication in Parkinson's disease and in prevention of age-related nigral changes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deprenyl reinitiates estrous cycles, reduces serum prolactin, and decreases the incidence of mammary and pituitary tumors in old acyclic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced catecholaminergic and serotoninergic activity in rat brain from weaning to sexual maturity: rationale for prophylactic (-)deprenyl (selegiline) medication.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memories of my 45 years in research.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sexually low performing male rats die earlier than their high performing peers and (-)deprenyl treatment eliminates this difference.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-deprenyl in the treatment of mild dementia of the Alzheimer type: results of a 15-month trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic treatment of aged mice with L-deprenyl produces marked striatal MAO-B inhibition but no beneficial effects on survival, motor performance, or nigral lipofuscin accumulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apparent antioxidant effect of l-deprenyl on hydroxyl radical formation and nigral injury elicited by MPP+ in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats. Further evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of deprenyl against 1-methyl-4-phenylpyridinium neurotoxicity in rat striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of therapeutic effects and mortality data of levodopa and levodopa combined with selegiline in patients with early, mild Parkinson's disease. Parkinson's Disease Research Group of the United Kingdom

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of deprenyl and tocopherol treatment on Parkinson's disease in DATATOP patients requiring levodopa. Parkinson Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)Deprenyl and (-)1-phenyl-2-propylaminopentane, [(-)PPAP], act primarily as potent stimulants of action potential-transmitter release coupling in the catecholaminergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenylethylamine and tyramine are mixed-acting sympathomimetic amines in the brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rationale and design of a multicenter study of selegiline and alpha-tocopherol in the treatment of Alzheimer disease using novel clinical outcomes. Alzheimer's Disease Cooperative Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic treatment of Syrian hamsters with low-dose selegiline increases life span in females but not males

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment with L-deprenyl prolongs life in elderly dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor effect of L-deprenyl in rats with carcinogen-induced mammary tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)Deprenyl (selegiline), a catecholaminergic activity enhancer (CAE) substance acting in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term administration of (-)-deprenyl increases mortality in male Wistar rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deprenyl administration in man: A selective monoamine oxidase B inhibitor without the ?cheese effect?

1 reference

https://pubmed.ncbi.nlm.nih.gov/11607046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1527-3458.2001.TB00202.X

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607046%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607046%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607046%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34405320&oldid=1391516914"