(Q34405501)

2 August 2017

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title

Biology of EWS/ETS fusions in Ewing's family tumors (English)

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2 August 2017

Arvand A

1

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2 August 2017

Denny CT

series ordinal

2

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2 August 2017

language of work or name

English

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publication date

1 September 2001

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2 August 2017

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2 August 2017

20

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2 August 2017

5747-5754

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2 August 2017

40

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204598

2 August 2017

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cites work

Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Ets and retroviruses - transduction and activation of members of the Ets oncogene family in viral oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

EWS-FLI1 fusion transcripts identified in patients with typical neuroblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

The mechanism of complex formation between Fli-1 and SRF transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Fli-1b is generated by usage of differential splicing and alternative promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Tyrosine kinase Pyk2 mediates G-protein-coupled receptor regulation of the Ewing sarcoma RNA-binding protein EWS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

The SH3 domain of Bruton's tyrosine kinase interacts with Vav, Sam68 and EWS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Transforming activity of EWS/FLI is not strictly dependent upon DNA-binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

The splicing factor U1C represses EWS/FLI-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Male sterility and enhanced radiation sensitivity in TLS(-/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

The ETS family member Tel antagonizes the Fli-1 phenotype in hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

EWS fli-1 antisense nanocapsules inhibits ewing sarcoma-related tumor in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Regulation of Ets function by protein - protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

SRE elements are binding sites for the fusion protein EWS-FLI-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Expression and function of Ets transcription factors in mammalian development: a regulatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

A novel zinc finger gene is fused to EWS in small round cell tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Xl-fli, the Xenopus homologue of the fli-1 gene, is expressed during embryogenesis in a restricted pattern evocative of neural crest cell distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

FLI-1 inhibits differentiation and induces proliferation of primary erythroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

BCR-ABL prevents c-jun-mediated and proteasome-dependent FUS (TLS) proteolysis through a protein kinase CbetaII-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

A new member of the ETS family fused to EWS in Ewing tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Novel oncogenic mutations in the WT1 Wilms' tumor suppressor gene: a t(11;22) fuses the Ewing's sarcoma gene, EWS1, to WT1 in desmoplastic small round cell tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Negative and translation termination-dependent positive control of FLI-1 protein synthesis by conserved overlapping 5' upstream open reading frames in Fli-1 mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Engagement of CD99 induces apoptosis through a calcineurin-independent pathway in Ewing's sarcoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Cabeza, a Drosophila gene encoding a novel RNA binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Fli-1, an Ets-related transcription factor, regulates erythropoietin-induced erythroid proliferation and differentiation: evidence for direct transcriptional repression of the Rb gene during differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Divergent Ewing's sarcoma EWS/ETS fusions confer a common tumorigenic phenotype on NIH3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

The role of Fli-1 in normal cell function and malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Chromosome study of Ewing's sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Variability of EWS chimaeric transcripts in Ewing tumours: a comparison of clinical and molecular data.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

The Ewing Family of Tumors -- A Subgroup of Small-Round-Cell Tumors Defined by Specific Chimeric Transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

Translocation involving chromosome 22 in Ewing's sarcoma. A cytogenetic study of four fresh tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

7 January 2021

Functional interference between retinoic acid or steroid hormone receptors and the oncoprotein Fli-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

7 January 2021

Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

7 January 2021

Child health benefits packages: lessons from Minnesota for State Children's Health Insurance Programs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

7 January 2021

Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

7 January 2021

Induction of p21Waf1/Cip1 by TNFα requires NF-κB activity and antagonizes apoptosis in Ewing tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

7 January 2021

Fusion of an ETS-family gene, EIAF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

7 January 2021

Fas-mediated apoptosis in Ewing's sarcoma cell lines by metalloproteinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

7 January 2021

Prognostic impact of INK4A deletion in Ewing sarcoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

7 January 2021

EWS.Fli-1 fusion protein interacts with hyperphosphorylated RNA polymerase II and interferes with serine-arginine protein-mediated RNA splicing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

7 January 2021

Combinatorial generation of variable fusion proteins in the Ewing family of tumours.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204598

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204598

1 reference

Dimensions Publication ID

2 August 2017

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1 reference