(Q34414149)

2 August 2017

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title

Anatomy and regulation of the central melanocortin system (English)

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2 August 2017

Roger D Cone

1

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PubMed ID

15856065

2 August 2017

language of work or name

English

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publication date

1 May 2005

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2 August 2017

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2 August 2017

8

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2 August 2017

571-578

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2 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nn1455

2 August 2017

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cites work

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

1 reference

7 January 2021

Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene

1 reference

7 January 2021

A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse

1 reference

7 January 2021

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

1 reference

7 January 2021

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

1 reference

7 January 2021

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1 reference

7 January 2021

A frameshift mutation in human MC4R is associated with a dominant form of obesity

1 reference

7 January 2021

A frameshift mutation in MC4R associated with dominantly inherited human obesity

1 reference

7 January 2021

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

1 reference

7 January 2021

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

1 reference

7 January 2021

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

1 reference

7 January 2021

Binge eating as a major phenotype of melanocortin 4 receptor gene mutations

1 reference

7 January 2021

Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat.

1 reference

7 January 2021

Evidence for two separate opiate peptide neuronal systems

1 reference

7 January 2021

alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain

1 reference

7 January 2021

Adrenocorticotropin and beta-lipotropin in the hypothalamus. Localization in the same arcuate neurons by sequential immunocytochemical procedures

1 reference

7 January 2021

Efferent ACTH-IR opiocortin projections from nucleus tractus solitarius: a hypothalamic deafferentation study.

1 reference

7 January 2021

Differential sensitivity of hypothalamic and medullary opiocortin and tyrosine hydroxylase neurons to the neurotoxic effects of monosodium glutamate (MSG).

1 reference

7 January 2021

GABA release from proopiomelanocortin neurons.

1 reference

7 January 2021

Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight.

1 reference

7 January 2021

The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice

1 reference

7 January 2021

Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus--relationship with NPY neurones.

1 reference

7 January 2021

Leptin activates neurons in ventrobasal hypothalamus and brainstem

1 reference

7 January 2021

The role of neuropeptide Y in the antiobesity action of the obese gene product

1 reference

7 January 2021

Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y.

1 reference

7 January 2021

Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin

1 reference

7 January 2021

Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus.

1 reference

7 January 2021

Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis

1 reference

7 January 2021

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

1 reference

7 January 2021

Role of brain insulin receptor in control of body weight and reproduction.

1 reference

7 January 2021

Hypothalamic insulin signaling is required for inhibition of glucose production

1 reference

7 January 2021

Androgen regulation of proopiomelanocortin gene expression and peptide content in the basal hypothalamus

1 reference

7 January 2021

Estrogen modulation of G-protein-coupled receptor activation of potassium channels in the central nervous system

1 reference

7 January 2021

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

1 reference

7 January 2021

The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.

1 reference

7 January 2021

Activation of central melanocortin pathways by fenfluramine

1 reference

7 January 2021

Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice.

1 reference

7 January 2021

Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels

1 reference

7 January 2021

Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons

1 reference

7 January 2021

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1 reference

7 January 2021

Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor

1 reference

7 January 2021

Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans.

1 reference

7 January 2021

Post-prandial decrease of circulating human ghrelin levels

1 reference

7 January 2021

A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans

1 reference

7 January 2021

Ghrelin induces adiposity in rodents

1 reference

7 January 2021

Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat

1 reference

7 January 2021

Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats

1 reference

7 January 2021

Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression

1 reference

7 January 2021

A role for ghrelin in the central regulation of feeding

1 reference

7 January 2021

Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway.

1 reference

7 January 2021

GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein

1 reference

7 January 2021

Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleus.

1 reference

7 January 2021

Ghrelin stimulates GH but not food intake in arcuate nucleus ablated rats

1 reference

7 January 2021

The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats

1 reference

7 January 2021

Human distribution and release of a putative new gut hormone, peptide YY

1 reference

7 January 2021

Two molecular forms of peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1-36 and PYY 3-36

1 reference

7 January 2021

Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism.

1 reference

7 January 2021

Gut hormone PYY(3-36) physiologically inhibits food intake

1 reference

7 January 2021

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).

1 reference

7 January 2021

Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice

1 reference

7 January 2021

Regulation of energy intake and the body weight: the glucostatic theory and the lipostatic hypothesis.

1 reference

7 January 2021

Central administration of oleic acid inhibits glucose production and food intake

1 reference

7 January 2021

Hypothalamic responses to long-chain fatty acids are nutritionally regulated

1 reference

7 January 2021

Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

1 reference

7 January 2021

AMP-activated protein kinase plays a role in the control of food intake

1 reference

7 January 2021

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

1 reference

7 January 2021

Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity

1 reference

7 January 2021

The role of gastrointestinal vagal afferents in the control of food intake: current prospects

1 reference

7 January 2021

Viscerotopic representation of the upper alimentary tract in the rat: sensory ganglia and nuclei of the solitary and spinal trigeminal tracts

1 reference

7 January 2021

CNS effects of circulating CCK8: involvement of brainstem neurones responding to gastric distension.

1 reference

7 January 2021

Relationships between the morphology and function of gastric- and intestine-sensitive neurons in the nucleus of the solitary tract

1 reference

7 January 2021

Distribution and neurochemical phenotypes of caudal medullary neurons activated to express cFos following peripheral administration of cholecystokinin

1 reference

7 January 2021

Immunocytochemical localization of ACTH perikarya in nucleus tractus solitarius: evidence for a second opiocortin neuronal system

1 reference

7 January 2021

Pro-opiomelanocortin-derived peptides (ACTH/beta-endorphin/alpha-MSH) in brainstem baroreceptor areas of the rat.

1 reference

7 January 2021

Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat.

1 reference

7 January 2021

Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight.

1 reference

7 January 2021

The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3/4 receptor stimulation

1 reference

7 January 2021

Cholecystokinin-decreased food intake in rhesus monkeys

1 reference

7 January 2021

Rapid development of tolerance to the behavioural actions of cholecystokinin

1 reference

7 January 2021

Abdominal Vagotomy Blocks the Satiety Effect of Cholecystokinin in the Rat

1 reference

7 January 2021

Evidence that decreased feeding induced by systemic injection of cholecystokinin is mediated by CCK-A receptors

1 reference

7 January 2021

Central insulin enhances sensitivity to cholecystokinin.

1 reference

7 January 2021

Synergy between leptin and cholecystokinin (CCK) to control daily caloric intake

1 reference

7 January 2021

Peptides that regulate food intake: norepinephrine is not required for reduction of feeding induced by cholecystokinin

1 reference

7 January 2021

Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system.

1 reference

7 January 2021

Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: regulation by cholecystokinin and opioids.

1 reference

7 January 2021

Melanocortin antagonists define two distinct pathways of cardiovascular control by alpha- and gamma-melanocyte-stimulating hormones.

1 reference

7 January 2021

Gamma-MSH, sodium metabolism, and salt-sensitive hypertension

1 reference

7 January 2021

Nerve growth factor regulates HCO3- absorption in thick ascending limb: modifying effects of vasopressin.

1 reference

7 January 2021

Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse

1 reference

7 January 2021

Melanocortin receptors and erectile function

1 reference

7 January 2021

Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra

1 reference

7 January 2021

Identifiers

DOI

10.1038/NN1455

1 reference

2 August 2017

1 reference

PubMed ID

15856065