(Q34419652)

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N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors

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Europe PubMed Central

PubMed publication ID

2 August 2017

N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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Zhu Li

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Mei Huang

2

1 reference

Europe PubMed Central

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2 August 2017

Junji Ichikawa

3

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Jin Dai

4

1 reference

Europe PubMed Central

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2 August 2017

Herbert Y Meltzer

5

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2 August 2017

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1 November 2005

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2 August 2017

Neuropsychopharmacology

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2 August 2017

30

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Europe PubMed Central

PubMed publication ID

2 August 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

1986-1995

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Clozapine in patients with chronic schizophrenia: serum level, EEG and memory performance

1 reference

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21 January 2018

Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice

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Simultaneous determination of clozapine and its N-desmethyl and N-oxide metabolites in plasma by liquid chromatography/electrospray tandem mass spectrometry and its application to plasma level monitoring in schizophrenic patients

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Methoctramine moderately improves memory but pirenzepine disrupts performance in delayed non-matching to position test.

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M1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices.

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21 January 2018

Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: a positron emission tomography study.

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Identification of a family of muscarinic acetylcholine receptor genes

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Chapter 12: Muscarinic acetylcholine receptor subtypes: localization and structure/function

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Functional partial agonism at cloned human muscarinic acetylcholine receptors.

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Radioreceptor binding profile of the atypical antipsychotic olanzapine.

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Muscarinic receptors as a target for drugs treating schizophrenia

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Clozapine increases both acetylcholine and dopamine release in rat ventral hippocampus: role of 5-HT1A receptor agonism

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Decreased muscarinic receptor binding in subjects with schizophrenia: a study of the human hippocampal formation.

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Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: a study of Brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment

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Effects of antipsychotic drugs on memory functions of schizophrenic patients

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Clozapine pharmacokinetics in children and adolescents with childhood-onset schizophrenia

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Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice

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Improvement in cognitive functions and psychiatric symptoms in treatment-refractory schizophrenic patients receiving clozapine.

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21 January 2018

Effects of clozapine in a selective muscarinic bioassay and on single cells of the rat hippocampus.

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21 January 2018

Atypical, but not typical, antipsychotic drugs increase cortical acetylcholine release without an effect in the nucleus accumbens or striatum

1 reference

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5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release

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Glutamate as a therapeutic target in psychiatric disorders

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The role of muscarinic receptor antagonism in antipsychotic-induced hippocampal acetylcholine release

1 reference

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Investigation of m1/m4 muscarinic receptors in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression disorder

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The effect of neuroleptics on cognitive and psychomotor function

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Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

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21 January 2018

Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists

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21 January 2018

Association of muscarinic m1 receptor genetic polymorphisms with psychiatric symptoms and cognitive function in schizophrenic patients

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21 January 2018

5-HT(2A) receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner

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Reduced expression of the muscarinic 1 receptor cortical subtype in schizophrenia

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Predictors of clinical outcome in schizophrenic patients responding to clozapine

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Serotonin receptors: their key role in drugs to treat schizophrenia

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The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia

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21 January 2018

Targeting metabotropic glutamate receptors for treatment of the cognitive symptoms of schizophrenia

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21 January 2018

Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: an in vivo microdialysis study

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Cognitive inflexibility and pre-frontal dysfunction in schizophrenia and mania

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Association of m1 and m2 muscarinic receptor proteins with asymmetric synapses in the primate cerebral cortex: morphological evidence for cholinergic modulation of excitatory neurotransmission

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Selective agents for muscarinic receptors linked to phosphoinositide breakdown

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Effects of clozapine on rat striatal muscarinic receptors coupled to inhibition of adenylyl cyclase activity and on the human cloned m4 receptor

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Acetylcholine in mind: a neurotransmitter correlate of consciousness?

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Selective M1 muscarinic receptor antagonists disrupt memory consolidation of inhibitory avoidance in rats.

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Cortical acetylcholine, reality distortion, schizophrenia, and Lewy Body Dementia: too much or too little cortical acetylcholine?

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Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding

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The binding of [3H]telenzepine to muscarinic acetylcholine receptors in calf forebrain

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Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat.

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N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity

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Cholinergic hyperactivity and negative schizophrenic symptoms. A model of cholinergic/dopaminergic interactions in schizophrenia

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Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus

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Distribution of clozapine and desmethylclozapine between blood and brain in rats

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Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia

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The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine

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Essential role of neocortical acetylcholine in spatial memory

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Effects of desmethylclozapine on Fos protein expression in the forebrain: in vivo biological activity of the clozapine metabolite

1 reference

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Muscarinic m4 receptor activation by some atypical antipsychotic drugs.

1 reference

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Clozapine is a potent and selective muscarinic M4 receptor agonist

1 reference

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Tissue concentrations of clozapine and its metabolites in the rat

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Muscarinic acetylcholine receptor subtypes: localization and structure/function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300768

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential regulation of molecular subtypes of muscarinic receptors in Alzheimer's disease.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Pirenzepine for clozapine-induced hypersalivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300768

7 January 2021

based on heuristic

inferred from DOI database lookup

M(2)/M(4)-muscarinic receptors mediate automodulation of acetylcholine outflow from mouse cortex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300768

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Coadministration of galanin antagonist M40 with a muscarinic M1 agonist improves delayed nonmatching to position choice accuracy in rats with cholinergic lesions.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Clozapine interaction with the M2 and M4 subtypes of muscarinic receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300768

7 January 2021

based on heuristic

inferred from DOI database lookup

Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300768

7 January 2021

based on heuristic

inferred from DOI database lookup

Relation of neuroleptic and anticholinergic medication to cognitive functions in schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300768

7 January 2021

based on heuristic

inferred from DOI database lookup

m1-m5 muscarinic receptor distribution in rat CNS by RT-PCR and HPLC.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300768

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1038/SJ.NPP.1300768

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

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