(Q34429389)

2 August 2017

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title

Probing the ubiquinone reduction site in bovine mitochondrial complex I using a series of synthetic ubiquinones and inhibitors (English)

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2 August 2017

Miyoshi H

1

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2 August 2017

publication date

1 June 2001

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Journal of Bioenergetics and Biomembranes

2 August 2017

published in

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2 August 2017

volume

33

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2 August 2017

issue

3

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2 August 2017

page(s)

223-231

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Characterization of the ubiquinone reduction site of mitochondrial complex I using bulky synthetic ubiquinones

2 August 2017

cites work

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12 December 2020

Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (Complex I)

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12 December 2020

Conformational gating of the electron transfer reaction QA-.QB --> QAQB-. in bacterial reaction centers of Rhodobacter sphaeroides determined by a driving force assay

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12 December 2020

Specificity of pyridinium inhibitors of the ubiquinone reduction sites in mitochondrial complex I

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12 December 2020

Inhibitor binding changes domain mobility in the iron-sulfur protein of the mitochondrial bc1 complex from bovine heart

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12 December 2020

Design syntheses and mitochondrial complex I inhibitory activity of novel acetogenin mimics

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12 December 2020

Comparison of the inhibitory action of synthetic capsaicin analogues with various NADH-ubiquinone oxidoreductases

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12 December 2020

NADH: ubiquinone oxidoreductase from bovine heart mitochondria. A fourth nuclear encoded subunit with a homologue encoded in chloroplast genomes

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12 December 2020

Comparison of the structural features of ubiquinone reduction sites between glucose dehydrogenase in Escherichia coli and bovine heart mitochondrial complex I.

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12 December 2020

Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I)

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12 December 2020

Studies on the respiratory chain-linked reduced nicotinamide adenine dinucleotide dehydrogenase. XVII. Reaction sites of piericidin A and rotenone.

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12 December 2020

Resolution of NADH:ubiquinone oxidoreductase from bovine heart mitochondria into two subcomplexes, one of which contains the redox centers of the enzyme

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12 December 2020

Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase.

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12 December 2020

Characterization of the inhibitory mechanism of 1-methyl-4-phenylpyridinium and 4-phenylpyridine analogs in inner membrane preparations.

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12 December 2020

Probing substrate binding site of the Escherichia coli quinol oxidases using synthetic ubiquinol analogues.

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12 December 2020

Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase).

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12 December 2020

Origin of selective inhibition of mitochondrial complex I by pyridinium-type inhibitor MP-24

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12 December 2020

NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone

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12 December 2020

Studies on the respiratory chain-linked nicotinamide adenine dinucleotide dehydrogenase. XXII. Rhein, a competitive inhibitor of the dehydrogenase

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12 December 2020

Inhibition of complex I by hydrophobic analogues of N-methyl-4-phenylpyridinium (MPP+) and the use of an ion-selective electrode to measure their accumulation by mitochondria and electron-transport particles

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12 December 2020

The specificity of mitochondrial complex I for ubiquinones

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12 December 2020

Structure-activity relationships of some complex I inhibitors

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12 December 2020

Membrane conformations and their relation to cytotoxicity of asimicin and its analogues

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12 December 2020

Electron transfer between the quinones in the photosynthetic reaction center and its coupling to conformational changes.

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12 December 2020

Evidence that the inhibition sites of the neurotoxic amine 1-methyl-4-phenylpyridinium (MPP+) and of the respiratory chain inhibitor piericidin A are the same

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12 December 2020

Effect of alkyl side chain variation on the electron-transfer activity of ubiquinone derivatives

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12 December 2020

Steady-state kinetics of high molecular weight (type-I) NADH dehydrogenase

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12 December 2020

Proton pumping of mitochondrial complex I: differential activation by analogs of ubiquinone

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12 December 2020

Essential structural factors of annonaceous acetogenins as potent inhibitors of mitochondrial complex I

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12 December 2020

The coupling of light-induced electron transfer and proton uptake as derived from crystal structures of reaction centres from Rhodopseudomonas viridis modified at the binding site of the secondary quinone, QB

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12 December 2020

Bullatacin and bullatacinone: two highly potent bioactive acetogenins from Annona bullata

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12 December 2020

Definition of crucial structural factors of acetogenins, potent inhibitors of mitochondrial complex I.

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12 December 2020

Pathways for proton release during ubihydroquinone oxidation by the bc(1) complex

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12 December 2020

Energy-dependent Complex I-associated ubisemiquinones in submitochondrial particles.

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12 December 2020

Influence of hydrocarbon tail structure on quinone binding and electron-transfer performance at the QA and QB sites of the photosynthetic reaction center protein

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12 December 2020

Proton-translocation by membrane-bound NADH:ubiquinone-oxidoreductase (complex I) through redox-gated ligand conduction

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12 December 2020

Comparison of the inhibitory action of natural rotenone and its stereoisomers with various NADH-ubiquinone reductases

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12 December 2020

Characterization of the complex I-associated ubisemiquinone species: toward the understanding of their functional roles in the electron/proton transfer reaction

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12 December 2020

Natural-Product Hybrids: Design, Synthesis, and Biological Evaluation of Quinone-Annonaceous Acetogenins This work was supported by the Deutsche Forschungs-gemeinschaft, Fonds der Chemische Industrie, and ASTA-Medica AG.

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12 December 2020

Role of the isoprenyl tail of ubiquinone in reaction with respiratory enzymes: studies with bovine heart mitochondrial complex I and Escherichia coli bo-type ubiquinol oxidase

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12 December 2020

Protein-ubiquinone interaction: synthesis and biological properties of ethoxy ubiquinone derivatives

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12 December 2020

The quinohemoprotein alcohol dehydrogenase of Gluconobacter suboxydans has ubiquinol oxidation activity at a site different from the ubiquinone reduction site

1 reference

12 December 2020

Inhibition by capsaicin of NADH-quinone oxidoreductases is correlated with the presence of energy-coupling site 1 in various organisms

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12 December 2020

Assay conditions for the mitochondrial NADH:coenzyme Q oxidoreductase

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12 December 2020

Specific interactions of monotetrahydrofuranic annonaceous acetogenins as inhibitors of mitochondrial complex I.

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12 December 2020

The gene locus of the proton-translocating NADH: ubiquinone oxidoreductase in Escherichia coli. Organization of the 14 genes and relationship between the derived proteins and subunits of mitochondrial complex I.

1 reference

12 December 2020

Synthesis, spectroscopy, and cytotoxicity of glycosylated acetogenin derivatives as promising molecules for cancer therapy

1 reference

12 December 2020

Structural dependence of the inhibition of mitochondrial respiration and of NADH oxidase by 1-methyl-4-phenylpyridinium (MPP+) analogs and their energized accumulation by mitochondria

1 reference

12 December 2020

Steady-state kinetics of the reduction of coenzyme Q analogs by complex I (NADH:ubiquinone oxidoreductase) in bovine heart mitochondria and submitochondrial particles.

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12 December 2020

Probing the ubiquinone reduction site of mitochondrial complex I using novel cationic inhibitors

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12 December 2020

Identifiers

DOI

10.1023/A:1010735019982

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Dimensions Publication ID

2 August 2017

1016159728

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