(Q34430407)

2 August 2017

title

Peptide deformylase: a target for novel antibiotics? (English)

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2 August 2017

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Pei D

1

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2 August 2017

language of work or name

English

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publication date

1 February 2001

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Expert Opinion on Therapeutic Targets

2 August 2017

published in

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2 August 2017

volume

5

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2 August 2017

issue

1

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2 August 2017

page(s)

23-40

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The crisis in antibiotic resistance

2 August 2017

cites work

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Deformylation and protein biosynthesis

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Protein chain initiation and deformylation in B. subtilis homogenates

21 January 2018

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Processing of the initiation methionine from proteins: properties of the Escherichia coli methionine aminopeptidase and its gene structure

21 January 2018

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N-terminal methionine-specific peptidase in Salmonella typhimurium

21 January 2018

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Extent of N-terminal methionine excision from Escherichia coli proteins is governed by the side-chain length of the penultimate amino acid

21 January 2018

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Role of methionine and formylation of initiator tRNA in initiation of protein synthesis in Escherichia coli

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Importance of formylability and anticodon stem sequence to give a tRNA(Met) an initiator identity in Escherichia coli

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Formylation is not essential for initiation of protein synthesis in all eubacteria.

21 January 2018

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Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene

21 January 2018

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Processing of the N termini of nascent polypeptide chains requires deformylation prior to methionine removal

21 January 2018

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Amino-terminal protein processing in Saccharomyces cerevisiae is an essential function that requires two distinct methionine aminopeptidases

21 January 2018

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Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.

21 January 2018

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The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

21 January 2018

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Primary structure of elongation factor Tu from Escherichia coli

21 January 2018

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The N-end rule: functions, mysteries, uses

21 January 2018

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Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferase

21 January 2018

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Zinc coordination, function, and structure of zinc enzymes and other proteins

21 January 2018

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Mapping of the active site zinc ligands of peptide deformylase.

21 January 2018

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A new subclass of the zinc metalloproteases superfamily revealed by the solution structure of peptide deformylase

21 January 2018

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Crystal structure of the Escherichia coli peptide deformylase

21 January 2018

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Structure of peptide deformylase and identification of the substrate binding site

21 January 2018

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Iron center, substrate recognition and mechanism of peptide deformylase

21 January 2018

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Structural basis for the design of antibiotics targeting peptide deformylase

21 January 2018

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Solution structure of nickel-peptide deformylase

21 January 2018

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Enzymatic properties of Escherichia coli peptide deformylase

21 January 2018

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Isolation and crystallization of functionally competent Escherichia coli peptide deformylase forms containing either iron or nickel in the active site

21 January 2018

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Control of peptide deformylase activity by metal cations

21 January 2018

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Characterization of cobalt(II)-substituted peptide deformylase: function of the metal ion and the catalytic residue Glu-133.

21 January 2018

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Expression of a synthetic gene coding for the amino acid sequence of Clostridium pasteurianum rubredoxin.

21 January 2018

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Expression of Desulfovibrio gigas desulforedoxin in Escherichia coli. Purification and characterization of mixed metal isoforms.

21 January 2018

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A survey of polypeptide deformylase function throughout the eubacterial lineage.

21 January 2018

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Structure-function relationships within the peptide deformylase family. Evidence for a conserved architecture of the active site involving three conserved motifs and a metal ion.

21 January 2018

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Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.5.1.23

Synthesis and antibacterial activity of peptide deformylase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.5.1.23

Determination of substrate specificity for peptide deformylase through the screening of a combinatorial peptide library

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.1.23

Substrate recognition and selectivity of peptide deformylase. Similarities and differences with metzincins and thermolysin

21 January 2018

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Biogenetic Autonomy Of Mitochondri

21 January 2018

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Cytochrome b, the var 1 protein, and subunits I and III of cytochrome c oxidase are synthesized without transient presequences in Saccharomyces cerevisiae

21 January 2018

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Presence of N-formyl- and N-acetyl-methionine in the proteins of honey bee thorax

21 January 2018

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Identification of the subunits of F1F0-ATPase from bovine heart mitochondria

21 January 2018

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The 42.5 kDa subunit of the NADH: ubiquinone oxidoreductase (complex I) in higher plants is encoded by the mitochondrial nad7 gene

21 January 2018

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Amino acid identities in the three redox center-carrying polypeptides of cytochrome bc1/b6f complexes

21 January 2018

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Peptide deformylase of eukaryotic protists: a target for new antiparasitic agents?

21 January 2018

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Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents

21 January 2018

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Continuous spectrophotometric assay of peptide deformylase.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.5.1.23

Identification of a potent peptide deformylase inhibitor from a rationally designed combinatorial library

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.5.1.23

Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor

21 January 2018

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Kinetics and thermodynamics of the interaction of 5-fluoro-2'-deoxyuridylate with thymidylate synthase

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.5.1.23

The Escherichia coli fmt gene, encoding methionyl-tRNA(fMet) formyltransferase, escapes metabolic control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.1.23

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.1.23

Purification and amino acid sequencing of naturally occurring N-formyl-methionyl oligopeptides from Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.1.23

Structures of N-terminally acetylated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.1.23

21 January 2018

Identifiers

DOI

10.1517/14728222.5.1.23

1 reference

2 August 2017

1 reference