(Q34435617)

2 August 2017

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title

Mechanism of action and preclinical profile of raloxifene, a selective estrogen receptor modulation (English)

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2 August 2017

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Bryant HU

1

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2 August 2017

publication date

1 January 2001

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Reviews in Endocrine and Metabolic Disorders

2 August 2017

published in

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2 August 2017

volume

2

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2 August 2017

issue

1

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2 August 2017

page(s)

129-138

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Endometrial response to raloxifene compared with placebo, cyclical hormone replacement therapy, and unopposed estrogen in postmenopausal women.

2 August 2017

cites work

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12 December 2020

Hormone therapy to prevent disease and prolong life in postmenopausal women

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12 December 2020

Expression of estrogen receptor beta in rat bone

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12 December 2020

Time-dependent changes in biochemical bone markers and serum cholesterol in ovariectomized rats: effects of raloxifene HCl, tamoxifen, estrogen, and alendronate

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12 December 2020

The effects of postmenopausal hormone replacement therapy on sympathetic skin response

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12 December 2020

Anabolic actions of parathyroid hormone on bone

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12 December 2020

ER beta: identification and characterization of a novel human estrogen receptor

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12 December 2020

Membrane estrogen receptors identified by multiple antibody labeling and impeded-ligand binding.

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12 December 2020

Differential expression of estrogen receptor-beta and estrogen receptor-alpha in the rat ovary

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12 December 2020

Estrogen receptor-beta messenger ribonucleic acid expression in the pituitary gland

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12 December 2020

Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators

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12 December 2020

Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern

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12 December 2020

An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens

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12 December 2020

The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons.

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12 December 2020

Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group

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12 December 2020

Cloning of a novel receptor expressed in rat prostate and ovary

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12 December 2020

"Add-back" estrogen reverses cognitive deficits induced by a gonadotropin-releasing hormone agonist in women with leiomyomata uteri

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12 December 2020

Structure-activity relationships of selective estrogen receptor modulators: modifications to the 2-arylbenzothiophene core of raloxifene

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12 December 2020

Cellular distribution and gene regulation of estrogen receptors alpha and beta in the rat pituitary gland

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12 December 2020

Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance

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12 December 2020

Mechanism of action of estrogen on cancellous bone balance in tibiae of ovariectomized growing rats: inhibition of indices of formation and resorption

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12 December 2020

The effect of postmenopausal estrogen therapy on bone density in elderly women

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12 December 2020

Expression of oestrogen receptor alpha and beta in rat heart: role of local oestrogen synthesis.

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12 December 2020

The Use of Estrogens and Progestins and the Risk of Breast Cancer in Postmenopausal Women

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12 December 2020

Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reaction

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12 December 2020

Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man

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12 December 2020

The effects of raloxifene on tibia histomorphometry in ovariectomized rats

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12 December 2020

A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity

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12 December 2020

Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study

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12 December 2020

AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer

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12 December 2020

Reversal of postmenopausal vertebral bone loss by oestrogen and progestogen: a double blind placebo controlled study

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12 December 2020

Estrogen and coronary heart disease in women

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12 December 2020

Raloxifene preserves bone strength and bone mass in ovariectomized rats

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12 December 2020

Identification of an estrogen response element activated by metabolites of 17beta-estradiol and raloxifene

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12 December 2020

Long-term prevention of postmenopausal osteoporosis by oestrogen. Evidence for an increased bone mass after delayed onset of oestrogen treatment

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12 December 2020

Molecular basis of agonism and antagonism in the oestrogen receptor

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12 December 2020

Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-kappaB site

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12 December 2020

Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal

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12 December 2020

Estrogen receptors alpha and beta form heterodimers on DNA

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12 December 2020

Molecular mechanisms of action of steroid/thyroid receptor superfamily members

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12 December 2020

The perimenopause: physiologic correlates and clinical management.

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12 December 2020

Longitudinal and cross-sectional analysis of raloxifene effects on tibiae from ovariectomized aged rats

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12 December 2020

Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta

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12 December 2020

Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats

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12 December 2020

Coexpression of estrogen receptor alpha and beta: poor prognostic factors in human breast cancer?

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12 December 2020

Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action

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12 December 2020

Estrogen-receptor interaction

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12 December 2020

Effects of low-dose long-term sodium fluoride preventive treatment on rat bone mass and biomechanical properties

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12 December 2020

Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription

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12 December 2020

Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: similarity to estrogen deficiency

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12 December 2020

Hormone replacement therapy in postmenopausal women with systemic lupus erythematosus.

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12 December 2020

Correction: raloxifene response needs more than an element

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12 December 2020

Coronary artery and cultured aortic smooth muscle cells express mRNA for both the classical estrogen receptor and the newly described estrogen receptor beta

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12 December 2020

Hormone replacement and cancer

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12 December 2020

Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

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12 December 2020

Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women

1 reference

12 December 2020

Comparative distribution of estrogen receptor-alpha (ER-alpha) and beta (ER-beta) mRNA in the rat pituitary, gonad, and reproductive tract

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12 December 2020

Estrogens as natural antioxidants of membrane phospholipid peroxidation

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12 December 2020

Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

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12 December 2020

Dual-energy x-ray absorptiometry of raloxifene effects on the lumbar vertebrae and femora of ovariectomized rats

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12 December 2020

Increased osteoclast development after estrogen loss: mediation by interleukin-6

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12 December 2020

Estrogens influence cholecystokinin stimulated pancreatic amylase release and acinar cell membrane cholecystokinin receptors in rat.

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12 December 2020

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

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12 December 2020

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens

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12 December 2020

Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens

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12 December 2020

Estrogen acutely stimulates nitric oxide synthase activity in fetal pulmonary artery endothelium

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12 December 2020

Overview of osteoporosis.

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12 December 2020

Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells.

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12 December 2020

Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats

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12 December 2020

Generation and reproductive phenotypes of mice lacking estrogen receptor beta

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12 December 2020

Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells

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12 December 2020

Anabolic Actions of Parathyroid Hormone on Bone*

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12 December 2020

Identifiers

DOI

10.1023/A:1010019410881

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Dimensions Publication ID

2 August 2017

1039807632

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